Failure to thrive

Failure to thrive (FTT),^[1] more recently known as faltering weight or weight faltering,^[2] is a term used in pediatric, adult as well as veterinary medicine, (where it is also referred to as ill thrift) to indicate insufficient weight gain or inappropriate weight loss. One of clinical findings in celiac disease in infants and children. When not more precisely defined, the term refers to pediatric patients. In children, it is usually defined in terms of weight, and can be evaluated either by a low weight for the child's age, or by a low rate of increase in the weight.^[3]

Children

As used by pediatricians, it covers poor physical growth of any cause and does not imply abnormal intellectual, social, or emotional development, although of course it can subsequently be a cause of such pathologies. The term has been used in different ways,^[4] and different objective standards have been defined.^[5][6] Many definitions use the 5th percentile as a cutoff.^[7]

Traditionally, causes of FTT have been divided into endogenous and exogenous causes. Initial investigation should consider physical causes, calorie intake and psychosocial assessment.

Endogenous (or "organic")

Causes are due to physical or mental issues with the child itself. It can include various inborn errors of metabolism. Problems with the gastrointestinal system such as gas and acid reflux are painful conditions which may make the child unwilling to take in sufficient nutrition. Cystic fibrosis, diarrhea, liver disease, and celiac disease make it more difficult for the body to absorb nutrition. Other causes include physical deformities such as cleft palate and tongue tie. Milk allergies can cause endogenous FTT. Also the metabolism may be raised by parasites, asthma, urinary tract infections, and other fever-inducing infections, or heart disease so that it becomes difficult to get in sufficient calories to meet the higher caloric demands.

Exogenous (or "nonorganic")

Caused by caregiver's actions. Examples include physical inability to produce enough breastmilk, using only babies' cues to regulate breastfeeding so as to not offer a sufficient numbers of feeds (sleepy baby syndrome),^[8] inability to procure formula when needed, purposely limiting total caloric intake (often for what the caregiver views as a more aesthetically pleasing child), and not offering sufficient age-appropriate solid foods for babies and toddlers over the age of six months.

Mixed

However, to think of the terms as dichotomous can be misleading, since both endogenous and exogenous factors may co-exist. For instance a child who is not getting sufficient nutrition may act content so that caregivers do not offer feedings of sufficient frequency or volume, and a child with severe acid reflux who appears to be in pain while eating may make a caregiver hesitant to offer sufficient feedings.

Recently the term faltering growth has become a popular replacement for failure to thrive, which in the minds of some represents a more euphemistic term.

Adults

The term "failure to thrive" is also applied to geriatrics, or more generally in adult medicine. is a descriptive, non-specific term that encompasses "not doing well". Manifestations of this condition include weight loss, decreased appetite, poor nutrition, and inactivity. Four syndromes are prevalent and predictive of adverse outcomes in patients with failure to thrive: impaired physical function, malnutrition, depression, and cognitive impairment.^[9][10]

See also

• Hospitalism
• Stunted growth

References