FZD2

Frizzled class receptor 2

Identifiers

FZD2 ; Fz2; fz-2; fzE2; hFz2

External IDs

OMIM: 600667 MGI: 1888513 HomoloGene: 20377 IUPHAR: 230 GeneCards: FZD2 Gene

Gene ontology
Molecular function	• G-protein coupled receptor activity • Wnt-protein binding • PDZ domain binding • Wnt-activated receptor activity
Cellular component	• cytoplasm • plasma membrane • integral component of membrane • clathrin-coated endocytic vesicle membrane • neuron projection membrane • apical part of cell
Biological process	• vasculature development • membranous septum morphogenesis • muscular septum morphogenesis • outflow tract morphogenesis • G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger • Wnt signaling pathway, calcium modulating pathway • cell-cell signaling • axonogenesis • brain development • sensory perception of smell • gonad development • neuron differentiation • positive regulation of cGMP metabolic process • epithelial cell differentiation • positive regulation of transcription, DNA-templated • positive regulation of sequence-specific DNA binding transcription factor activity • hard palate development • canonical Wnt signaling pathway • inner ear receptor cell development • cochlea morphogenesis • planar cell polarity pathway involved in neural tube closure
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
42.63 – 42.64 Mb

Chr 11:
102.6 – 102.61 Mb

PubMed search

Frizzled-2 is a protein that in humans is encoded by the FZD2 gene.^[1]^[2]^[3]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary.^[3]

References

↑ Zhao Z, Lee CC, Baldini A, Caskey CT (Nov 1995). "A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1". Genomics 27 (2): 370–3. doi:10.1006/geno.1995.1060. PMID 7558010.
↑ Sagara N, Toda G, Hirai M, Terada M, Katoh M (Dec 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155.
↑ 3.0 3.1 "Entrez Gene: FZD2 frizzled homolog 2 (Drosophila)".

External links

"Frizzled Receptors: FZD₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Wang Y, Macke JP, Abella BS et al. (1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.". J. Biol. Chem. 271 (8): 4468–76. doi:10.1074/jbc.271.8.4468. PMID 8626800.
Finch PW, He X, Kelley MJ et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
Tanaka S, Akiyoshi T, Mori M et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
Hering H, Sheng M (2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.". FEBS Lett. 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Oishi I, Suzuki H, Onishi N et al. (2004). "The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway". Genes Cells 8 (7): 645–54. doi:10.1046/j.1365-2443.2003.00662.x. PMID 12839624.
Omoto S, Hayashi T, Kitahara K et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3

Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)

Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)

Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine (D1 D2 D3 D4 D5) Histamine (H1 H2 H3 H4) Melatonin (1A 1B 1C) TAAR (1 2 3 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 (1 2) FPRL1 OXE Prostaglandin (DP (1 2), EP (1 2 3 4), FP) Prostacyclin Thromboxane

Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Lactate Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Niacin (1 2) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide	B/W (1 2) FF (1 2) S Y (1 2 4 5) Neuromedin (B U (1 2)) Neurotensin (1 2)

Other	Anaphylatoxin (C3a C5a) Angiotensin (1 2) Apelin Bombesin (BRS3 GRPR NMBR) Bradykinin (B1 B2) Chemokine Cholecystokinin (A B) Endothelin (A B) Formyl peptide (1 2 3) FSH Galanin (1 2 3) GHB receptor Gonadotropin-releasing hormone (1 2) Ghrelin Kisspeptin Luteinizing hormone/choriogonadotropin MAS (1 1L D E F G X1 X2 X3 X4) Melanocortin (1 2 3 4 5) MCHR (1 2) Motilin Opioid (Delta Kappa Mu Nociceptin & Zeta, but not Sigma) Orexin (1 2) Oxytocin Prokineticin (1 2) Prolactin-releasing peptide Relaxin (1 2 3 4) Somatostatin (1 2 3 4 5) Tachykinin (1 2 3) Thyrotropin Thyrotropin-releasing hormone Urotensin-II Vasopressin (1A 1B 2)

Miscellaneous

Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 77 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)

Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin like

Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)

Adhesion	ADGRG (1 2 3 4 5 6 7)

Other	Brain-specific angiogenesis inhibitor (1 2 3) Cadherin (1 2 3) Calcitonin CALCRL CD97 Corticotropin-releasing hormone (1 2) EMR (1 2 3) Glucagon (GR GIPR GLP1R GLP2R) Growth hormone releasing hormone PACAPR1 GPR Latrophilin (1 2 3 ELTD1) Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste	TAS1R (1 2 3) TAS2R (1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60)

Other	Calcium-sensing receptor GABA B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F: Frizzled / Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)

Smoothened	Smoothened

Index of signal transduction

Description	Intercellular neuropeptides growth factors cytokines hormones Cell surface receptors ligand-gated enzyme-linked G protein-coupled immunoglobulin superfamily integrins neuropeptide growth factor cytokine Intracellular adaptor proteins GTP-binding MAP kinase Calcium signaling Lipid signaling Pathways hedgehog Wnt TGF beta MAPK ERK notch JAK-STAT apoptosis hippo TLR

FZD2

See also

References

External links

Further reading