FXR2
| Fragile X mental retardation, autosomal homolog 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | FXR2 ; FMR1L2; FXR2P | ||||||||||||
| External IDs | OMIM: 605339 MGI: 1346074 HomoloGene: 21014 GeneCards: FXR2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9513 | 23879 | |||||||||||
| Ensembl | ENSG00000129245 | ENSMUSG00000018765 | |||||||||||
| UniProt | P51116 | Q6P5B5 | |||||||||||
| RefSeq (mRNA) | NM_004860 | NM_011814 | |||||||||||
| RefSeq (protein) | NP_004851 | NP_035944 | |||||||||||
| Location (UCSC) | Chr 17: 7.49 – 7.52 Mb | Chr 11: 69.63 – 69.65 Mb | |||||||||||
| PubMed search | |||||||||||||
Fragile X mental retardation syndrome-related protein 2 is a protein that in humans is encoded by the FXR2 gene.[1][2][3]
The protein encoded by this gene is an RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome.[3]
Interactions
FXR2 has been shown to interact with FXR1,[1][4] LCMT1,[5] FMR1[1][4][6] and CYFIP1.[7]
References
- ↑ 1.0 1.1 1.2 Zhang Y, O'Connor JP, Siomi MC, Srinivasan S, Dutra A, Nussbaum RL, Dreyfuss G (Jan 1996). "The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2". EMBO J 14 (21): 5358–66. PMC 394645. PMID 7489725.
- ↑ Tamanini F, Willemsen R, van Unen L, Bontekoe C, Galjaard H, Oostra BA, Hoogeveen AT (Oct 1997). "Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis". Hum Mol Genet 6 (8): 1315–22. doi:10.1093/hmg/6.8.1315. PMID 9259278.
- ↑ 3.0 3.1 "Entrez Gene: FXR2 fragile X mental retardation, autosomal homolog 2".
- ↑ 4.0 4.1 Siomi, M C; Zhang Y; Siomi H; Dreyfuss G (Jul 1996). "Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them". Mol. Cell. Biol. (UNITED STATES) 16 (7): 3825–32. ISSN 0270-7306. PMC 231379. PMID 8668200.
- ↑ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- ↑ Ceman, S; Brown V; Warren S T (Dec 1999). "Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex". Mol. Cell. Biol. (UNITED STATES) 19 (12): 7925–32. ISSN 0270-7306. PMC 84877. PMID 10567518.
- ↑ Schenck, A; Bardoni B; Moro A; Bagni C; Mandel J L (Jul 2001). "A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (15): 8844–9. doi:10.1073/pnas.151231598. ISSN 0027-8424. PMC 37523. PMID 11438699.
Further reading
- Siomi MC, Zhang Y, Siomi H, Dreyfuss G (1996). "Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them". Mol. Cell. Biol. 16 (7): 3825–32. PMC 231379. PMID 8668200.
- Joseph DR (1998). "The rat androgen-binding protein (ABP/SHBG) gene contains triplet repeats similar to unstable triplets: evidence that the ABP/SHBG and the fragile X-related 2 genes overlap". Steroids 63 (1): 2–4. doi:10.1016/S0039-128X(97)00087-1. PMID 9437788.
- Tamanini F, Bontekoe C, Bakker CE et al. (1999). "Different targets for the fragile X-related proteins revealed by their distinct nuclear localizations". Hum. Mol. Genet. 8 (5): 863–9. doi:10.1093/hmg/8.5.863. PMID 10196376.
- Bardoni B, Schenck A, Mandel JL (2000). "A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein". Hum. Mol. Genet. 8 (13): 2557–66. doi:10.1093/hmg/8.13.2557. PMID 10556305.
- Ceman S, Brown V, Warren ST (2000). "Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex". Mol. Cell. Biol. 19 (12): 7925–32. PMC 84877. PMID 10567518.
- Cousin P, Billotte J, Chaubert P, Shaw P (2000). "Physical map of 17p13 and the genes adjacent to p53". Genomics 63 (1): 60–8. doi:10.1006/geno.1999.6062. PMID 10662545.
- Tamanini F, Kirkpatrick LL, Schonkeren J et al. (2000). "The fragile X-related proteins FXR1P and FXR2P contain a functional nucleolar-targeting signal equivalent to the HIV-1 regulatory proteins". Hum. Mol. Genet. 9 (10): 1487–93. doi:10.1093/hmg/9.10.1487. PMID 10888599.
- Schenck A, Bardoni B, Moro A et al. (2001). "A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P". Proc. Natl. Acad. Sci. U.S.A. 98 (15): 8844–9. doi:10.1073/pnas.151231598. PMC 37523. PMID 11438699.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Brill LM, Salomon AR, Ficarro SB et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rush J, Moritz A, Lee KA et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Lim J, Hao T, Shaw C et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.