FLT4

Fms-related tyrosine kinase 4
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsFLT4 ; FLT41; LMPH1A; PCL; VEGFR3
External IDsOMIM: 136352 MGI: 95561 HomoloGene: 7321 IUPHAR: 1814 ChEMBL: 1955 GeneCards: FLT4 Gene
EC number2.7.10.1
Orthologs
SpeciesHumanMouse
Entrez232414257
EnsemblENSG00000037280ENSMUSG00000020357
UniProtP35916P35917
RefSeq (mRNA)NM_002020NM_008029
RefSeq (protein)NP_002011NP_032055
Location (UCSC)Chr 5:
180.03 – 180.08 Mb		Chr 11:
49.61 – 49.65 Mb
PubMed search

Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the FLT4 gene.[1][2]

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA.[1]

Interactions

FLT4 has been shown to interact with SHC1.[3][4][5]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: FLT4 fms-related tyrosine kinase 4".
  2. ↑ Galland F, Karamysheva A, Mattei MG, Rosnet O, Marchetto S, Birnbaum D (June 1992). "Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene". Genomics 13 (2): 475–8. doi:10.1016/0888-7543(92)90277-Y. PMID 1319394.
  3. ↑ Pajusola, K; Aprelikova O; Pelicci G; Weich H; Claesson-Welsh L; Alitalo K (December 1994). "Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors". Oncogene (ENGLAND) 9 (12): 3545–55. ISSN 0950-9232. PMID 7970715.
  4. ↑ Fournier, E; Blaikie P; Rosnet O; Margolis B; Birnbaum D; Borg J P (January 1999). "Role of tyrosine residues and protein interaction domains of SHC adaptor in VEGF receptor 3 signaling". Oncogene (ENGLAND) 18 (2): 507–14. doi:10.1038/sj.onc.1202315. ISSN 0950-9232. PMID 9927207.
  5. ↑ Fournier, E; Rosnet O; Marchetto S; Turck C W; Rottapel R; Pelicci P G; Birnbaum D; Borg J P (May 1996). "Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase". J. Biol. Chem. (UNITED STATES) 271 (22): 12956–63. doi:10.1074/jbc.271.22.12956. ISSN 0021-9258. PMID 8662748.

External links

Further reading

  • Petrova TV, Makinen T, Alitalo K (1999). "Signaling via vascular endothelial growth factor receptors.". Exp. Cell Res. 253 (1): 117–30. doi:10.1006/excr.1999.4707. PMID 10579917.
  • Aprelikova O, Pajusola K, Partanen J et al. (1992). "FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter.". Cancer Res. 52 (3): 746–8. PMID 1310071.
  • Galland F, Karamysheva A, Mattei MG et al. (1992). "Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene.". Genomics 13 (2): 475–8. doi:10.1016/0888-7543(92)90277-Y. PMID 1319394.
  • Pajusola K, Aprelikova O, Korhonen J et al. (1992). "FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines.". Cancer Res. 52 (20): 5738–43. PMID 1327515.
  • Fournier E, Dubreuil P, Birnbaum D, Borg JP (1995). "Mutation at tyrosine residue 1337 abrogates ligand-dependent transforming capacity of the FLT4 receptor.". Oncogene 11 (5): 921–31. PMID 7675451.
  • Pajusola K, Aprelikova O, Armstrong E et al. (1993). "Two human FLT4 receptor tyrosine kinase isoforms with distinct carboxy terminal tails are produced by alternative processing of primary transcripts.". Oncogene 8 (11): 2931–7. PMID 7692369.
  • Pajusola K, Aprelikova O, Pelicci G et al. (1994). "Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors.". Oncogene 9 (12): 3545–55. PMID 7970715.
  • Galland F, Karamysheva A, Pebusque MJ et al. (1993). "The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor.". Oncogene 8 (5): 1233–40. PMID 8386825.
  • Fournier E, Rosnet O, Marchetto S et al. (1996). "Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase.". J. Biol. Chem. 271 (22): 12956–63. doi:10.1074/jbc.271.22.12956. PMID 8662748.
  • Lee J, Gray A, Yuan J et al. (1996). "Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4.". Proc. Natl. Acad. Sci. U.S.A. 93 (5): 1988–92. doi:10.1073/pnas.93.5.1988. PMC 39896. PMID 8700872.
  • Kukk E, Lymboussaki A, Taira S et al. (1997). "VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development.". Development 122 (12): 3829–37. PMID 9012504.
  • Achen MG, Jeltsch M, Kukk E et al. (1998). "Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4).". Proc. Natl. Acad. Sci. U.S.A. 95 (2): 548–53. doi:10.1073/pnas.95.2.548. PMC 18457. PMID 9435229.
  • Ferrell RE, Levinson KL, Esman JH et al. (1999). "Hereditary lymphedema: evidence for linkage and genetic heterogeneity.". Hum. Mol. Genet. 7 (13): 2073–8. doi:10.1093/hmg/7.13.2073. PMID 9817924.
  • Fournier E, Blaikie P, Rosnet O et al. (1999). "Role of tyrosine residues and protein interaction domains of SHC adaptor in VEGF receptor 3 signaling.". Oncogene 18 (2): 507–14. doi:10.1038/sj.onc.1202315. PMID 9927207.
  • Karkkainen MJ, Ferrell RE, Lawrence EC et al. (2000). "Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema.". Nat. Genet. 25 (2): 153–9. doi:10.1038/75997. PMID 10835628.
  • Irrthum A, Karkkainen MJ, Devriendt K et al. (2000). "Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase.". Am. J. Hum. Genet. 67 (2): 295–301. doi:10.1086/303019. PMC 1287178. PMID 10856194.
  • Wang JF, Zhang XF, Groopman JE (2001). "Stimulation of beta 1 integrin induces tyrosine phosphorylation of vascular endothelial growth factor receptor-3 and modulates cell migration.". J. Biol. Chem. 276 (45): 41950–7. doi:10.1074/jbc.M101370200. PMID 11553610.
  • Baldwin ME, Roufail S, Halford MM et al. (2001). "Multiple forms of mouse vascular endothelial growth factor-D are generated by RNA splicing and proteolysis.". J. Biol. Chem. 276 (47): 44307–14. doi:10.1074/jbc.M106188200. PMID 11574540.
  • Walter JW, North PE, Waner M et al. (2002). "Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma.". Genes Chromosomes Cancer 33 (3): 295–303. doi:10.1002/gcc.10028. PMID 11807987.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.