FGF7

Fibroblast growth factor 7

PDB rendering based on 1qqk.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1qqk

Identifiers

Symbols

FGF7 ; HBGF-7; KGF

External IDs

OMIM: 148180 MGI: 95521 HomoloGene: 7316 GeneCards: FGF7 Gene

Gene ontology
Molecular function	• fibroblast growth factor receptor binding • protein binding • growth factor activity • heparin binding • chemoattractant activity
Cellular component	• extracellular region • Golgi apparatus
Biological process	• signal transduction • epidermal growth factor receptor signaling pathway • positive regulation of cell proliferation • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway • epidermis development • response to wounding • mesenchymal cell proliferation • positive regulation of keratinocyte proliferation • hair follicle morphogenesis • actin cytoskeleton reorganization • protein localization to cell surface • Fc-epsilon receptor signaling pathway • innate immune response • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • positive regulation of epithelial cell proliferation • positive regulation of peptidyl-tyrosine phosphorylation • positive chemotaxis • positive regulation of keratinocyte migration • positive regulation of cell division • branching involved in salivary gland morphogenesis • positive regulation of epithelial cell proliferation involved in lung morphogenesis • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling • secretion by lung epithelial cell involved in lung growth
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 15:
49.72 – 49.78 Mb

Chr 2:
126.03 – 126.09 Mb

PubMed search

Keratinocyte growth factor is a protein that in humans is encoded by the FGF7 gene.^[1]^[2]^[3]

Function

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.^[3]

Interactions

FGF7 has been shown to interact with Perlecan.^[4]

References

↑ Mattei MG, deLapeyrière O, Bresnick J, Dickson C, Birnbaum D, Mason I (Mar 1995). "Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively". Mammalian Genome 6 (3): 196–7. doi:10.1007/BF00293012. PMID 7749227. Vancouver style error (help)
↑ Kelley MJ, Pech M, Seuanez HN, Rubin JS, O'Brien SJ, Aaronson SA (Oct 1992). "Emergence of the keratinocyte growth factor multigene family during the great ape radiation". Proceedings of the National Academy of Sciences of the United States of America 89 (19): 9287–91. doi:10.1073/pnas.89.19.9287. PMC 50111. PMID 1409637.
↑ 3.0 3.1 "Entrez Gene: FGF7 fibroblast growth factor 7 (keratinocyte growth factor)".
↑ Mongiat M, Taylor K, Otto J, Aho S, Uitto J, Whitelock JM et al. (Mar 2000). "The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7". The Journal of Biological Chemistry 275 (10): 7095–100. doi:10.1074/jbc.275.10.7095. PMID 10702276.

Beer HD, Gassmann MG, Munz B, Steiling H, Engelhardt F, Bleuel K et al. (Dec 2000). "Expression and function of keratinocyte growth factor and activin in skin morphogenesis and cutaneous wound repair". The Journal of Investigative Dermatology. Symposium Proceedings / the Society for Investigative Dermatology, Inc. [And] European Society for Dermatological Research 5 (1): 34–9. doi:10.1046/j.1087-0024.2000.00009.x. PMID 11147673.
Ware LB, Matthay MA (May 2002). "Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair". American Journal of Physiology. Lung Cellular and Molecular Physiology 282 (5): L924–40. doi:10.1152/ajplung.00439.2001. PMID 11943656.
Finch PW, Rubin JS (2004). "Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair". Advances in Cancer Research. Advances in Cancer Research 91: 69–136. doi:10.1016/S0065-230X(04)91003-2. ISBN 978-0-12-006691-9. PMID 15327889.
Ishibashi T, Bottaro DP, Chan A, Miki T, Aaronson SA (Dec 1992). "Expression cloning of a human dual-specificity phosphatase". Proceedings of the National Academy of Sciences of the United States of America 89 (24): 12170–4. doi:10.1073/pnas.89.24.12170. PMC 50720. PMID 1281549.
Aaronson SA, Bottaro DP, Miki T, Ron D, Finch PW, Fleming TP et al. (1992). "Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity". Annals of the New York Academy of Sciences 638: 62–77. doi:10.1111/j.1749-6632.1991.tb49018.x. PMID 1664700.
Finch PW, Rubin JS, Miki T, Ron D, Aaronson SA (Aug 1989). "Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth". Science 245 (4919): 752–5. doi:10.1126/science.2475908. PMID 2475908.
Rubin JS, Osada H, Finch PW, Taylor WG, Rudikoff S, Aaronson SA (Feb 1989). "Purification and characterization of a newly identified growth factor specific for epithelial cells". Proceedings of the National Academy of Sciences of the United States of America 86 (3): 802–6. doi:10.1073/pnas.86.3.802. PMC 286565. PMID 2915979.
Ron D, Reich R, Chedid M, Lengel C, Cohen OE, Chan AM et al. (Mar 1993). "Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor". The Journal of Biological Chemistry 268 (8): 5388–94. PMID 7680645.
Yan G, Fukabori Y, McBride G, Nikolaropolous S, McKeehan WL (Aug 1993). "Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy". Molecular and Cellular Biology 13 (8): 4513–22. PMC 360063. PMID 7687739.
Werner S, Smola H, Liao X, Longaker MT, Krieg T, Hofschneider PH et al. (Nov 1994). "The function of KGF in morphogenesis of epithelium and reepithelialization of wounds". Science 266 (5186): 819–22. doi:10.1126/science.7973639. PMID 7973639.
Wilson SE, Walker JW, Chwang EL, He YG (Jul 1993). "Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea". Investigative Ophthalmology & Visual Science 34 (8): 2544–61. PMID 8392040.
Guo L, Degenstein L, Fuchs E (Jan 1996). "Keratinocyte growth factor is required for hair development but not for wound healing". Genes & Development 10 (2): 165–75. doi:10.1101/gad.10.2.165. PMID 8566750.
Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F et al. (Jun 1996). "Receptor specificity of the fibroblast growth factor family". The Journal of Biological Chemistry 271 (25): 15292–7. doi:10.1074/jbc.271.25.15292. PMID 8663044.
Post M, Souza P, Liu J, Tseu I, Wang J, Kuliszewski M et al. (Oct 1996). "Keratinocyte growth factor and its receptor are involved in regulating early lung branching". Development 122 (10): 3107–15. PMID 8898224.
Zimonjic DB, Kelley MJ, Rubin JS, Aaronson SA, Popescu NC (Oct 1997). "Fluorescence in situ hybridization analysis of keratinocyte growth factor gene amplification and dispersion in evolution of great apes and humans". Proceedings of the National Academy of Sciences of the United States of America 94 (21): 11461–5. doi:10.1073/pnas.94.21.11461. PMC 23506. PMID 9326632.
Winkles JA, Alberts GF, Chedid M, Taylor WG, DeMartino S, Rubin JS (Dec 1997). "Differential expression of the keratinocyte growth factor (KGF) and KGF receptor genes in human vascular smooth muscle cells and arteries". Journal of Cellular Physiology 173 (3): 380–6. doi:10.1002/(SICI)1097-4652(199712)173:3<380::AID-JCP10>3.0.CO;2-G. PMID 9369951.
Ishibashi T, Tanaka T, Nibu K, Ishimoto S, Kaga K (Oct 1998). "Keratinocyte growth factor and its receptor messenger RNA expression in nasal mucosa and nasal polyps". The Annals of Otology, Rhinology, and Laryngology 107 (10 Pt 1): 885–90. PMID 9794620.
Mongiat M, Taylor K, Otto J, Aho S, Uitto J, Whitelock JM et al. (Mar 2000). "The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7". The Journal of Biological Chemistry 275 (10): 7095–100. doi:10.1074/jbc.275.10.7095. PMID 10702276.

PDB gallery

1qqk: THE CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 7 (KERATINOCYTE GROWTH FACTOR)

Growth factors

Fibroblast

FGF receptor ligands:	FGF1/FGF2/FGF5 FGF3/FGF4/FGF6

KGF	FGF7/FGF10/FGF22 FGF8/FGF17/FGF18 FGF9/FGF16/FGF20

FGF homologous factors:	FGF11 FGF12 FGF13 FGF14

hormone-like:	FGF19 FGF21 FGF23

EGF-like domain

TGFβ pathway

TGF-β
- TGF-β1
- TGF-β2
- TGF-β3

Insulin-like

IGF-1
IGF-2

Platelet-derived

Vascular endothelial

VEGF-A
VEGF-B
VEGF-C
VEGF-D
PGF

Other

Index of signal transduction

Description	Intercellular neuropeptides growth factors cytokines hormones Cell surface receptors ligand-gated enzyme-linked G protein-coupled immunoglobulin superfamily integrins neuropeptide growth factor cytokine Intracellular adaptor proteins GTP-binding MAP kinase Calcium signaling Lipid signaling Pathways hedgehog Wnt TGF beta MAPK ERK notch JAK-STAT apoptosis hippo TLR

FGF7

Function

Interactions

References

Further reading