FGF12

Fibroblast growth factor 12

PDB rendering based on 1q1u.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1Q1U, 4JQ0

Identifiers

Symbols

FGF12 ; FGF12B; FHF1

External IDs

OMIM: 601513 MGI: 109183 HomoloGene: 10874 GeneCards: FGF12 Gene

Gene ontology
Molecular function	• fibroblast growth factor receptor binding • growth factor activity • heparin binding • sodium channel regulator activity • ion channel binding
Cellular component	• extracellular space • nucleus
Biological process	• regulation of membrane depolarization • signal transduction • JNK cascade • cell-cell signaling • synaptic transmission • nervous system development • heart development • adult locomotory behavior • fibroblast growth factor receptor signaling pathway • positive regulation of sodium ion transport • neuromuscular process • cardiac muscle cell action potential involved in contraction • regulation of sodium ion transmembrane transport • regulation of sodium ion transmembrane transporter activity • negative regulation of cation channel activity
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
191.86 – 192.49 Mb

Chr 16:
28.16 – 28.45 Mb

PubMed search

Fibroblast growth factor 12 is a protein that in humans is encoded by the FGF12 gene.^[1]^[2]^[3]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.^[3]

References

↑ Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SH, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Oct 1996). "Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development". Proc Natl Acad Sci U S A 93 (18): 9850–7. doi:10.1073/pnas.93.18.9850. PMC 38518. PMID 8790420.
↑ Liu Y, Chiu IM (Nov 1997). "Assignment of FGF12, the human FGF homologous factor 1 gene, to chromosome 3q29-->3qter by fluorescence in situ hybridization". Cytogenet Cell Genet 78 (1): 48–9. doi:10.1159/000134625. PMID 9345906.
↑ 3.0 3.1 "Entrez Gene: FGF12 fibroblast growth factor 12".

Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
Kok LD, Tsui SK, Waye M et al. (1999). "Cloning and characterization of a cDNA encoding a novel fibroblast growth factor preferentially expressed in human heart.". Biochem. Biophys. Res. Commun. 255 (3): 717–21. doi:10.1006/bbrc.1999.0178. PMID 10049777.
Schoorlemmer J, Goldfarb M (2001). "Fibroblast growth factor homologous factors are intracellular signaling proteins.". Curr. Biol. 11 (10): 793–7. doi:10.1016/S0960-9822(01)00232-9. PMC 3216481. PMID 11378392.
Liu CJ, Dib-Hajj SD, Renganathan M et al. (2003). "Modulation of the cardiac sodium channel Nav1.5 by fibroblast growth factor homologous factor 1B.". J. Biol. Chem. 278 (2): 1029–36. doi:10.1074/jbc.M207074200. PMID 12401812.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Olsen SK, Garbi M, Zampieri N et al. (2003). "Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs.". J. Biol. Chem. 278 (36): 34226–36. doi:10.1074/jbc.M303183200. PMID 12815063.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Popovici C, Conchonaud F, Birnbaum D, Roubin R (2004). "Functional phylogeny relates LET-756 to fibroblast growth factor 9.". J. Biol. Chem. 279 (38): 40146–52. doi:10.1074/jbc.M405795200. PMID 15199049.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

PDB gallery

1q1u: Crystal structure of human FHF1b (FGF12b)

Growth factors

Fibroblast

FGF receptor ligands:	FGF1/FGF2/FGF5 FGF3/FGF4/FGF6

KGF	FGF7/FGF10/FGF22 FGF8/FGF17/FGF18 FGF9/FGF16/FGF20

FGF homologous factors:	FGF11 FGF12 FGF13 FGF14

hormone-like:	FGF19 FGF21 FGF23

EGF-like domain

TGFβ pathway

TGF-β
- TGF-β1
- TGF-β2
- TGF-β3

Insulin-like

IGF-1
IGF-2

Platelet-derived

Vascular endothelial

VEGF-A
VEGF-B
VEGF-C
VEGF-D
PGF

Other

Index of signal transduction

Description	Intercellular neuropeptides growth factors cytokines hormones Cell surface receptors ligand-gated enzyme-linked G protein-coupled immunoglobulin superfamily integrins neuropeptide growth factor cytokine Intracellular adaptor proteins GTP-binding MAP kinase Calcium signaling Lipid signaling Pathways hedgehog Wnt TGF beta MAPK ERK notch JAK-STAT apoptosis hippo TLR

FGF12

References

Further reading