FGF10

Fibroblast growth factor 10
PDB rendering based on 1nun.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1NUN
Identifiers
Symbol	FGF10
External IDs	OMIM: 602115 MGI: 1099809 HomoloGene: 3284 GeneCards: FGF10 Gene
Gene ontology Molecular function • fibroblast growth factor receptor binding • type 2 fibroblast growth factor receptor binding • growth factor activity • heparin binding • chemoattractant activity Cellular component • extracellular region • extracellular space • nucleus • plasma membrane • cell surface • extracellular matrix Biological process • activation of MAPK activity • angiogenesis • metanephros development • organ induction • mesonephros development • blood vessel remodeling • metanephros morphogenesis • epidermal growth factor receptor signaling pathway • determination of left/right symmetry • salivary gland development • negative regulation of cell proliferation • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway • regulation of smoothened signaling pathway • embryonic pattern specification • epithelial cell migration • positive regulation of epithelial cell migration • positive regulation of keratinocyte proliferation • pituitary gland development • embryonic genitalia morphogenesis • thyroid gland development • otic vesicle formation • positive regulation of vascular endothelial growth factor receptor signaling pathway • pancreas development • hair follicle morphogenesis • embryonic camera-type eye development • actin cytoskeleton reorganization • positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle • response to estradiol • response to lipopolysaccharide • positive regulation of ATPase activity • lacrimal gland development • regulation of activin receptor signaling pathway • protein localization to cell surface • somatic stem cell maintenance • Fc-epsilon receptor signaling pathway • wound healing • tissue regeneration • odontogenesis of dentin-containing tooth • muscle cell fate commitment • positive regulation of MAPK cascade • keratinocyte proliferation • innate immune response • positive regulation of DNA repair • positive regulation of DNA replication • positive regulation of Notch signaling pathway • positive regulation of transcription, DNA-templated • positive regulation of mitotic cell cycle • positive regulation of transcription from RNA polymerase II promoter • positive regulation of Ras protein signal transduction • regulation of saliva secretion • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • positive regulation of fibroblast proliferation • spleen development • thymus development • embryonic digestive tract morphogenesis • branching morphogenesis of an epithelial tube • female genitalia morphogenesis • male genitalia morphogenesis • positive regulation of lymphocyte proliferation • epithelial cell proliferation • urothelial cell proliferation • positive regulation of urothelial cell proliferation • positive regulation of epithelial cell proliferation • positive regulation of peptidyl-tyrosine phosphorylation • white fat cell differentiation • positive chemotaxis • induction of positive chemotaxis • smooth muscle cell differentiation • positive regulation of keratinocyte migration • radial glial cell differentiation • positive regulation of epithelial cell proliferation involved in wound healing • limb bud formation • lung epithelium development • lung saccule development • bronchiole morphogenesis • bud outgrowth involved in lung branching • mesenchymal-epithelial cell signaling involved in lung development • Type II pneumocyte differentiation • fibroblast growth factor receptor signaling pathway involved in mammary gland specification • mammary gland bud formation • submandibular salivary gland formation • epithelial cell proliferation involved in salivary gland morphogenesis • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling • branch elongation involved in salivary gland morphogenesis • regulation of prostatic bud formation • semicircular canal fusion • mesenchymal cell differentiation involved in lung development • secretion by lung epithelial cell involved in lung growth • lung proximal/distal axis specification • tear secretion • positive regulation of white fat cell proliferation • ERK1 and ERK2 cascade • positive regulation of ERK1 and ERK2 cascade • Harderian gland development • negative regulation of cell cycle arrest • positive regulation of hair follicle cell proliferation • positive regulation of canonical Wnt signaling pathway • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2255	14165
Ensembl	ENSG00000070193	ENSMUSG00000021732
UniProt	O15520	O35565
RefSeq (mRNA)	NM_004465	NM_008002
RefSeq (protein)	NP_004456	NP_032028
Location (UCSC)	Chr 5: 44.3 – 44.39 Mb	Chr 13: 118.67 – 118.79 Mb
PubMed search

Fibroblast growth factor 10 is a protein that in humans is encoded by the FGF10 gene.^[1][2]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of limb bud formation. This gene is also implicated to be a primary factor in the process of wound healing.^[2]

References

Further reading

External links

• OMIM entry on aplasia of lacrimal and salivary glands

PDB gallery 1nun: Crystal Structure Analysis of the FGF10-FGFR2b Complex