FGD3

FYVE, RhoGEF and PH domain containing 3

PDB rendering based on 2coc.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2COC

Identifiers

Symbols

FGD3 ; ZFYVE5

External IDs

MGI: 1353657 HomoloGene: 22925 GeneCards: FGD3 Gene

Gene ontology
Molecular function	• guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity • small GTPase binding • metal ion binding
Cellular component	• ruffle • cytoplasm • Golgi apparatus • cytosol • cytoskeleton • lamellipodium
Biological process	• cytoskeleton organization • small GTPase mediated signal transduction • regulation of cell shape • actin cytoskeleton organization • positive regulation of Rho GTPase activity • positive regulation of apoptotic process • regulation of Cdc42 GTPase activity • positive regulation of GTPase activity • filopodium assembly • neurotrophin TRK receptor signaling pathway • regulation of small GTPase mediated signal transduction • apoptotic signaling pathway
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 9:
95.71 – 95.8 Mb

Chr 13:
49.26 – 49.32 Mb

PubMed search

FYVE, RhoGEF and PH domain-containing protein 3 is a protein that in humans is encoded by the FGD3 gene.^[1]^[2]

References

↑ Hattori A, Okumura K, Nagase T, Kikuno R, Hirosawa M, Ohara O (Feb 2001). "Characterization of long cDNA clones from human adult spleen". DNA Res 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
↑ "Entrez Gene: FGD3 FYVE, RhoGEF and PH domain containing 3".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Pasteris NG, Nagata K, Hall A, Gorski JL (2000). "Isolation, characterization, and mapping of the mouse Fgd3 gene, a new Faciogenital Dysplasia (FGD1; Aarskog Syndrome) gene homologue". Gene 242 (1–2): 237–47. doi:10.1016/S0378-1119(99)00518-1. PMID 10721717.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Delague V, Jacquier A, Hamadouche T et al. (2007). "Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H". Am. J. Hum. Genet. 81 (1): 1–16. doi:10.1086/518428. PMC 1950914. PMID 17564959.

PDB gallery

2coc: Solution structure of the C-terminal PH domain of FYVE, RhoGEF and PH domain containing protein 3 (FGD3) from human

GTP-binding protein regulators

GTPase activating protein

Monomeric	Chimerin CHN1 CHN2 RasGAP NF1 IQGAP Tuberous sclerosis protein TSC1 TSC2

Heterotrimeric	Regulator of G protein signalling: RGS1 RGS2 RGS3 RGS4 RGS5 RGS6 RGS7 RGS8 RGS9 RGS10 RGS11 RGS12 RGS13 RGS14 RGS16 RGS17 RGS18 RGS19 RGS20 RGS21

Guanine nucleotide exchange factor

EIF2B Son of Sevenless Ras-GRF1

FGD	FGD1 FGD2 FGD3 FGD4

ALS2 SIL1 IQSEC2

Other

Guanosine nucleotide dissociation inhibitors

Index of signal transduction

Description	Intercellular neuropeptides growth factors cytokines hormones Cell surface receptors ligand-gated enzyme-linked G protein-coupled immunoglobulin superfamily integrins neuropeptide growth factor cytokine Intracellular adaptor proteins GTP-binding MAP kinase Calcium signaling Lipid signaling Pathways hedgehog Wnt TGF beta MAPK ERK notch JAK-STAT apoptosis hippo TLR

FGD3

References

Further reading