FCRL3

Fc receptor-like 3
Identifiers
SymbolsFCRL3 ; CD307c; FCRH3; IFGP3; IRTA3; SPAP2
External IDsOMIM: 606510 MGI: 3053558 HomoloGene: 76447 GeneCards: FCRL3 Gene
Orthologs
SpeciesHumanMouse
Entrez115352329693
EnsemblENSG00000160856ENSMUSG00000048031
UniProtQ96P31Q68SN8
RefSeq (mRNA)NM_001024667NM_001113238
RefSeq (protein)NP_443171NP_001106709
Location (UCSC)Chr 1:
157.64 – 157.67 Mb		Chr 3:
87.44 – 87.46 Mb
PubMed search

Fc receptor-like protein 3 is a protein that in humans is encoded by the FCRL3 gene.[1][2][3]

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.[3]

Interactions

FCRL3 has been shown to interact with PTPN6.[4]

References

  1. ↑ Davis RS, Wang YH, Kubagawa H, Cooper MD (Aug 2001). "Identification of a family of Fc receptor homologs with preferential B cell expression". Proc Natl Acad Sci U S A 98 (17): 9772–7. doi:10.1073/pnas.171308498. PMC 55528. PMID 11493702.
  2. ↑ Davis RS, Dennis G Jr, Kubagawa H, Cooper MD (May 2002). "Fc receptor homologs (FcRH1-5) extend the Fc receptor family". Curr Top Microbiol Immunol 266: 85–112. doi:10.1007/978-3-662-04700-2_7. PMID 12014205.
  3. ↑ 3.0 3.1 "Entrez Gene: FCRL3 Fc receptor-like 3".
  4. ↑ Xu, Ming-jiang; Zhao Runxiang; Cao Hongxi; Zhao Zhizhuang Joe (May 2002). "SPAP2, an Ig family receptor containing both ITIMs and ITAMs". Biochem. Biophys. Res. Commun. (United States) 293 (3): 1037–46. doi:10.1016/S0006-291X(02)00332-7. ISSN 0006-291X. PMID 12051764.

Further reading

  • Miller I; Hatzivassiliou G; Cattoretti G et al. (2002). "IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells". Blood 99 (8): 2662–9. doi:10.1182/blood.V99.8.2662. PMID 11929751.
  • Xu MJ, Zhao R, Cao H, Zhao ZJ (2002). "SPAP2, an Ig family receptor containing both ITIMs and ITAMs". Biochem. Biophys. Res. Commun. 293 (3): 1037–46. doi:10.1016/S0006-291X(02)00332-7. PMID 12051764.
  • Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Kochi Y; Yamada R; Suzuki A et al. (2005). "A functional variant in FcRH3, encoding Fc Receptor Homolog 3, is associated with rheumatoid arthritis and several autoimmunities". Nat. Genet. 37 (5): 478–85. doi:10.1038/ng1540. PMC 1362949. PMID 15838509.
  • Simmonds MJ; Heward JM; Carr-Smith J et al. (2006). "Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease". J. Clin. Endocrinol. Metab. 91 (3): 1056–61. doi:10.1210/jc.2005-1634. PMID 16384851.
  • Eyre S; Bowes J; Potter C et al. (2007). "Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity?". Arthritis Res. Ther. 8 (4): R117. doi:10.1186/ar2006. PMC 1779391. PMID 16859508.
  • Umemura T; Ota M; Yoshizawa K et al. (2007). "Lack of association between FCRL3 and FcgammaRII polymorphisms in Japanese type 1 autoimmune hepatitis". Clin. Immunol. 122 (3): 338–42. doi:10.1016/j.clim.2006.08.012. PMID 17020818.
  • Schäfer N; Blaumeiser B; Becker T et al. (2007). "Investigation of the functional variant c.-169T > C of the Fc receptor-like 3 (FCRL3) gene in alopecia areata". Int. J. Immunogenet. 33 (6): 393–5. doi:10.1111/j.1744-313X.2006.00633.x. PMID 17117947.
  • Newman WG; Zhang Q; Liu X et al. (2007). "Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population". Arthritis Rheum. 54 (12): 3820–7. doi:10.1002/art.22270. PMID 17133579.
  • Choi CB; Kang CP; Seong SS et al. (2007). "The -169C/T polymorphism in FCRL3 is not associated with susceptibility to rheumatoid arthritis or systemic lupus erythematosus in a case-control study of Koreans". Arthritis Rheum. 54 (12): 3838–41. doi:10.1002/art.22248. PMID 17133581.
  • Owen CJ; Kelly H; Eden JA et al. (2007). "Analysis of the Fc receptor-like-3 (FCRL3) locus in Caucasians with autoimmune disorders suggests a complex pattern of disease association". J. Clin. Endocrinol. Metab. 92 (3): 1106–11. doi:10.1210/jc.2006-2183. PMID 17200162.
  • Taylor AI, Gould HJ, Sutton BJ, Calvert RA (2007). "The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL". Immunogenetics 59 (4): 323–8. doi:10.1007/s00251-007-0195-9. PMID 17273841.
  • Martínez A; Núñez C; Martín MC et al. (2007). "Epistatic interaction between FCRL3 and MHC in Spanish patients with IBD". Tissue Antigens 69 (4): 313–7. doi:10.1111/j.1399-0039.2007.00816.x. PMID 17389014.
  • Martínez A; Mas A; de Las Heras V et al. (2007). "FcRL3 and multiple sclerosis pathogenesis: role in autoimmunity?". J. Neuroimmunol. 189 (1–2): 132–6. doi:10.1016/j.jneuroim.2007.06.018. PMID 17617473.