FCN1
| Ficolin (collagen/fibrinogen domain containing) 1 | |||||||||||||
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 PDB rendering based on 2d39. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | FCN1 ; FCNM | ||||||||||||
| External IDs | OMIM: 601252 MGI: 1341158 HomoloGene: 1518 GeneCards: FCN1 Gene | ||||||||||||
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| Species | Human | Mouse | |||||||||||
| Entrez | 2219 | 14134 | |||||||||||
| Ensembl | ENSG00000085265 | ENSMUSG00000026835 | |||||||||||
| UniProt | O00602 | O70497 | |||||||||||
| RefSeq (mRNA) | NM_002003 | NM_010190 | |||||||||||
| RefSeq (protein) | NP_001994 | NP_034320 | |||||||||||
| Location (UCSC) | Chr 9: 137.8 – 137.81 Mb | Chr 2: 28.08 – 28.08 Mb | |||||||||||
| PubMed search | |||||||||||||
Ficolin-1, and also commonly termed M-ficolin is a protein that in humans is encoded by the FCN1 gene.[1][2][3]
Proteins of the ficolin family consist of a leader peptide, a short N-terminal segment, followed by a collagen-like domain, and a C-terminal fibrinogen-like domain. The name of ficolin was derived from the latter two domains. The collagen-like and the fibrinogen-like domains are also found in other proteins such as tenascins, while the former is also found in complement protein C1q and collectins, which include mannose-binding lectin and lung surfactant proteins. Ficolins selectively recognize acetylated compounds. M-ficolin encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity.[3] Several SNPs have been described in the FCN1 gene with impact on serum concentrations of M-ficolin and the ligand binding ability [4]
References
- ↑ Lu J, Tay PN, Kon OL, Reid KB (Mar 1996). "Human ficolin: cDNA cloning, demonstration of peripheral blood leucocytes as the major site of synthesis and assignment of the gene to chromosome 9". Biochem J 313 (2): 473–8. PMC 1216931. PMID 8573080.
- ↑ Endo Y, Sato Y, Matsushita M, Fujita T (Feb 1997). "Cloning and characterization of the human lectin P35 gene and its related gene". Genomics 36 (3): 515–21. doi:10.1006/geno.1996.0497. PMID 8884275.
- ↑ 3.0 3.1 "Entrez Gene: FCN1 ficolin (collagen/fibrinogen domain containing) 1".
- ↑ http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0050585
Further reading
- Lu J, Le Y (1999). "Ficolins and the fibrinogen-like domain". Immunobiology 199 (2): 190–9. doi:10.1016/s0171-2985(98)80026-0. PMID 9777405.
- Ichijo H, Hellman U, Wernstedt C et al. (1993). "Molecular cloning and characterization of ficolin, a multimeric protein with fibrinogen- and collagen-like domains". J. Biol. Chem. 268 (19): 14505–13. PMID 7686157.
- Matsushita M, Endo Y, Taira S et al. (1996). "A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin". J. Biol. Chem. 271 (5): 2448–54. doi:10.1074/jbc.271.5.2448. PMID 8576206.
- Harumiya S, Takeda K, Sugiura T et al. (1997). "Characterization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1". J. Biochem. 120 (4): 745–51. doi:10.1093/oxfordjournals.jbchem.a021474. PMID 8947836.
- Le Y, Tan SM, Lee SH et al. (1997). "Purification and binding properties of a human ficolin-like protein". J. Immunol. Methods 204 (1): 43–9. doi:10.1016/S0022-1759(97)00029-X. PMID 9202708.
- Matsushita M, Endo Y, Fujita T (2000). "Cutting edge: complement-activating complex of ficolin and mannose-binding lectin-associated serine protease". J. Immunol. 164 (5): 2281–4. doi:10.4049/jimmunol.164.5.2281. PMID 10679061.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Zeng L, Dai J, Ying K et al. (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart". J. Hum. Genet. 48 (3): 159–62. doi:10.1007/s100380300025. PMID 12624729.
- Gregory LA, Thielens NM, Matsushita M et al. (2004). "The X-ray structure of human mannan-binding lectin-associated protein 19 (MAp19) and its interaction site with mannan-binding lectin and L-ficolin". J. Biol. Chem. 279 (28): 29391–7. doi:10.1074/jbc.M402687200. PMID 15117939.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Frederiksen PD, Thiel S, Larsen CB, Jensenius JC (2006). "M-ficolin, an innate immune defence molecule, binds patterns of acetyl groups and activates complement". Scand. J. Immunol. 62 (5): 462–73. doi:10.1111/j.1365-3083.2005.01685.x. PMID 16305643.
- Tanio M, Kondo S, Sugio S, Kohno T (2007). "Trivalent recognition unit of innate immunity system: crystal structure of trimeric human M-ficolin fibrinogen-like domain". J. Biol. Chem. 282 (6): 3889–95. doi:10.1074/jbc.M608627200. PMID 17148457.
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