FCGR3B

Fc fragment of IgG, low affinity IIIb, receptor (CD16b)

PDB rendering based on 1e4j.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1E4J, 1E4K, 1FNL, 1T83, 1T89

Identifiers

Symbols

FCGR3B ; CD16; CD16b; FCG3; FCGR3; FCR-10; FCRIII; FCRIIIb

External IDs

OMIM: 610665 HomoloGene: 477 ChEMBL: 5842 GeneCards: FCGR3B Gene

Gene ontology
Molecular function	• IgG binding
Cellular component	• plasma membrane • anchored component of membrane • extracellular vesicular exosome
Biological process	• immune response
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
161.59 – 161.6 Mb

Chr 1:
171.02 – 171.03 Mb

PubMed search

FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor), also known as CD16b (Cluster of Differentiation 16b), is a human gene.^[1]

Clinical relevance

Mutations and copy-number variations in this gene have been associated to clinical cases of glomerulonephritis.^[2]

References

↑ "Entrez Gene: FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)".
↑ Aitman, TJ; Dong, R, Vyse, TJ, Norsworthy, PJ, Johnson, MD, Smith, J, Mangion, J, Roberton-Lowe, C, Marshall, AJ, Petretto, E, Hodges, MD, Bhangal, G, Patel, SG, Sheehan-Rooney, K, Duda, M, Cook, PR, Evans, DJ, Domin, J, Flint, J, Boyle, JJ, Pusey, CD, Cook, HT (Feb 16, 2006). "Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans.". Nature 439 (7078): 851–5. doi:10.1038/nature04489. PMID 16482158.

Qiu WQ, de Bruin D, Brownstein BH et al. (1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination.". Science 248 (4956): 732–5. doi:10.1126/science.2139735. PMID 2139735.
Peltz GA, Grundy HO, Lebo RV et al. (1989). "Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG.". Proc. Natl. Acad. Sci. U.S.A. 86 (3): 1013–7. doi:10.1073/pnas.86.3.1013. PMC 286611. PMID 2521732.
Scallon BJ, Scigliano E, Freedman VH et al. (1989). "A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms.". Proc. Natl. Acad. Sci. U.S.A. 86 (13): 5079–83. doi:10.1073/pnas.86.13.5079. PMC 297560. PMID 2525780.
Ravetch JV, Perussia B (1989). "Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions.". J. Exp. Med. 170 (2): 481–97. doi:10.1084/jem.170.2.481. PMC 2189395. PMID 2526846.
Simmons D, Seed B (1988). "The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein.". Nature 333 (6173): 568–70. doi:10.1038/333568a0. PMID 2967436.
Gessner JE, Grussenmeyer T, Kolanus W, Schmidt RE (1995). "The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions.". J. Biol. Chem. 270 (3): 1350–61. doi:10.1074/jbc.270.3.1350. PMID 7836402.
Gessner JE, Grussenmeyer T, Dumbsky M, Schmidt RE (1997). "Separate promoters from proximal and medial control regions contribute to the natural killer cell-specific transcription of the human FcgammaRIII-A (CD16-A) receptor gene.". J. Biol. Chem. 271 (48): 30755–64. doi:10.1074/jbc.271.48.30755. PMID 8940055.
Bux J, Stein EL, Bierling P et al. (1997). "Characterization of a new alloantigen (SH) on the human neutrophil Fc gamma receptor IIIb.". Blood 89 (3): 1027–34. PMID 9028335.
Zocchi MR, Rubartelli A, Morgavi P, Poggi A (1998). "HIV-1 Tat inhibits human natural killer cell function by blocking L-type calcium channels.". J. Immunol. 161 (6): 2938–43. PMID 9743356.
Sondermann P, Huber R, Oosthuizen V, Jacob U (2000). "The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex.". Nature 406 (6793): 267–73. doi:10.1038/35018508. PMID 10917521.
Zhang Y, Boesen CC, Radaev S et al. (2000). "Crystal structure of the extracellular domain of a human Fc gamma RIII.". Immunity 13 (3): 387–95. doi:10.1016/S1074-7613(00)00038-8. PMID 11021536.
Watanabe Y, Shimada E, Fujiwara K et al. (2001). "Nucleotide sequence of a new Fc gamma receptor IIIB allele that codes for a neutrophil antigen.". Tissue Antigens 56 (3): 272–5. doi:10.1034/j.1399-0039.2000.560310.x. PMID 11034564.
Bharadwaj D, Mold C, Markham E, Du Clos TW (2001). "Serum amyloid P component binds to Fc gamma receptors and opsonizes particles for phagocytosis.". J. Immunol. 166 (11): 6735–41. doi:10.4049/jimmunol.166.11.6735. PMID 11359830.
Davoine F, Lavigne S, Chakir J et al. (2002). "Expression of FcgammaRIII (CD16) on human peripheral blood eosinophils increases in allergic conditions.". J. Allergy Clin. Immunol. 109 (3): 463–9. doi:10.1067/mai.2002.121952. PMID 11897993.
Fossati G, Moots RJ, Bucknall RC, Edwards SW (2002). "Differential role of neutrophil Fcgamma receptor IIIB (CD16) in phagocytosis, bacterial killing, and responses to immune complexes.". Arthritis Rheum. 46 (5): 1351–61. doi:10.1002/art.10230. PMID 12115243.
Cauza K, Grassauer A, Hinterhuber G et al. (2003). "FcgammaRIII expression on cultured human keratinocytes and upregulation by interferon-gamma.". J. Invest. Dermatol. 119 (5): 1074–9. doi:10.1046/j.1523-1747.2002.19527.x. PMID 12445195.
Siriboonrit U, Tsuchiya N, Sirikong M et al. (2004). "Association of Fcgamma receptor IIb and IIIb polymorphisms with susceptibility to systemic lupus erythematosus in Thais.". Tissue Antigens 61 (5): 374–83. doi:10.1034/j.1399-0039.2003.00047.x. PMID 12753656.
Breij EC, van der Pol WL, van Winsen L et al. (2003). "No association of Fc gamma RIIa, Fc gamma RIIIa and Fc gamma RIIIb polymorphisms with MS.". J. Neuroimmunol. 140 (1–2): 210–5. doi:10.1016/S0165-5728(03)00207-8. PMID 12864991.
Tong Y, Jin J, Yan L et al. (2003). "FCGR3B gene frequencies and FCGR3 variants in a Chinese population from Zhejiang Province". Ann. Hematol. 82 (9): 574–8. doi:10.1007/s00277-003-0725-y. PMID 12898191.
Tanaka S, Edberg JC, Chatham W et al. (2004). "Fc gamma RIIIb allele-sensitive release of alpha-defensins: anti-neutrophil cytoplasmic antibody-induced release of chemotaxins". J. Immunol. 171 (11): 6090–6. doi:10.4049/jimmunol.171.11.6090. PMID 14634123.

PDB gallery

1e4j: CRYSTAL STRUCTURE OF THE SOLUBLE HUMAN FC-GAMMA RECEPTOR III

1e4k: CRYSTAL STRUCTURE OF SOLUBLE HUMAN IGG1 FC FRAGMENT-FC-GAMMA RECEPTOR III COMPLEX

1fnl: CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII

1t83: CRYSTAL STRUCTURE OF A HUMAN TYPE III FC GAMMA RECEPTOR IN COMPLEX WITH AN FC FRAGMENT OF IGG1 (ORTHORHOMBIC)

1t89: CRYSTAL STRUCTURE OF A HUMAN TYPE III FC GAMMA RECEPTOR IN COMPLEX WITH AN FC FRAGMENT OF IGG1 (HEXAGONAL)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

FCGR3B

Clinical relevance

See also

References

Further reading