FCGR2A

Fc fragment of IgG, low affinity IIa, receptor (CD32)

PDB rendering based on 1fcg.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1FCG, 1H9V, 3D5O, 3RY4, 3RY5, 3RY6

Identifiers

Symbols

FCGR2A ; CD32; CD32A; CDw32; FCG2; FCGR2; FCGR2A1; FcGR; IGFR2

External IDs

OMIM: 146790 MGI: 95500 HomoloGene: 47936 ChEMBL: 5841 GeneCards: FCGR2A Gene

Gene ontology
Molecular function	• IgG binding
Cellular component	• plasma membrane • integral component of membrane • extracellular vesicular exosome
Biological process	• Fc-gamma receptor signaling pathway involved in phagocytosis • innate immune response
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
161.48 – 161.49 Mb

Chr 1:
171.05 – 171.06 Mb

PubMed search

Low affinity immunoglobulin gamma Fc region receptor II-a is a protein that in humans is encoded by the FCGR2A gene.^[1]^[2]

Interactions

FCGR2A has been shown to interact with PIK3R1^[3]^[4] and Syk.^[4]^[5]

References

↑ Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (June 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science 248 (4956): 732–5. doi:10.1126/science.2139735. PMID 2139735.
↑ "Entrez Gene: FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)".
↑ Chacko, G W; Brandt J T; Coggeshall K M; Anderson C L (May 1996). "Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides". J. Biol. Chem. (UNITED STATES) 271 (18): 10775–81. doi:10.1074/jbc.271.18.10775. ISSN 0021-9258. PMID 8631888.
↑ 4.0 4.1 Ibarrola, I; Vossebeld P J; Homburg C H; Thelen M; Roos D; Verhoeven A J (July 1997). "Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa". Biochim. Biophys. Acta (NETHERLANDS) 1357 (3): 348–58. doi:10.1016/S0167-4889(97)00034-7. ISSN 0006-3002. PMID 9268059.
↑ Kim, M K; Pan X Q; Huang Z Y; Hunter S; Hwang P H; Indik Z K; Schreiber A D (January 2001). "Fc gamma receptors differ in their structural requirements for interaction with the tyrosine kinase Syk in the initial steps of signaling for phagocytosis". Clin. Immunol. (UNITED STATES) 98 (1): 125–32. doi:10.1006/clim.2000.4955. ISSN 1521-6616. PMID 11141335.

McKenzie SE (2002). "Humanized mouse models of FcR clearance in immune platelet disorders.". Blood Rev. 16 (1): 3–5. doi:10.1054/blre.2001.0170. PMID 11913983.
Ernst LK, van de Winkel JG, Chiu IM, Anderson CL (1992). "Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products.". J. Biol. Chem. 267 (22): 15692–700. PMID 1379234.
Seki T (1989). "Identification of multiple isoforms of the low-affinity human IgG Fc receptor.". Immunogenetics 30 (1): 5–12. doi:10.1007/BF02421463. PMID 2526077.
Hessian PA, Highton J, Palmer DG (1989). "Quantification of macrophage cell surface molecules in rheumatoid arthritis". Clin. Exp. Immunol. 77 (1): 47–51. PMC 1541930. PMID 2527651.
Brooks DG, Qiu WQ, Luster AD, Ravetch JV (1989). "Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes". J. Exp. Med. 170 (4): 1369–85. doi:10.1084/jem.170.4.1369. PMC 2189488. PMID 2529342.
Lanier LL, Cwirla S, Yu G et al. (1990). "Membrane anchoring of a human IgG Fc receptor (CD16) determined by a single amino acid". Science 246 (4937): 1611–3. doi:10.1126/science.2531919. PMID 2531919.
Stuart SG, Trounstine ML, Vaux DJ et al. (1987). "Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII)". J. Exp. Med. 166 (6): 1668–84. doi:10.1084/jem.166.6.1668. PMC 2188792. PMID 2824655.
Hibbs ML, Bonadonna L, Scott BM et al. (1988). "Molecular cloning of a human immunoglobulin G Fc receptor". Proc. Natl. Acad. Sci. U.S.A. 85 (7): 2240–4. doi:10.1073/pnas.85.7.2240. PMC 279966. PMID 2965389.
Huizinga TW, van der Schoot CE, Jost C et al. (1988). "The PI-linked receptor FcRIII is released on stimulation of neutrophils". Nature 333 (6174): 667–9. doi:10.1038/333667a0. PMID 2967437.
Sammartino L, Webber LM, Hogarth PM et al. (1988). "Assignment of the gene coding for human FcRII (CD32) to bands q23q24 on chromosome 1". Immunogenetics 28 (5): 380–1. doi:10.1007/BF00364238. PMID 2971615.
Stengelin S, Stamenkovic I, Seed B (1988). "Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning". EMBO J. 7 (4): 1053–9. PMC 454434. PMID 3402431.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Chacko GW, Brandt JT, Coggeshall KM, Anderson CL (1996). "Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides". J. Biol. Chem. 271 (18): 10775–81. doi:10.1074/jbc.271.18.10775. PMID 8631888.
Salmon JE, Millard S, Schachter LA et al. (1996). "Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans". J. Clin. Invest. 97 (5): 1348–54. doi:10.1172/JCI118552. PMC 507190. PMID 8636449.
Bewarder N, Weinrich V, Budde P et al. (1996). "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation". Mol. Cell. Biol. 16 (9): 4735–43. PMC 231474. PMID 8756631.
Sármay G, Koncz G, Gergely J (1997). "Human type II Fcgamma receptors inhibit B cell activation by interacting with the p21(ras)-dependent pathway". J. Biol. Chem. 271 (48): 30499–504. doi:10.1074/jbc.271.48.30499. PMID 8940017.
Ibarrola I, Vossebeld PJ, Homburg CH et al. (1997). "Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa". Biochim. Biophys. Acta 1357 (3): 348–58. doi:10.1016/S0167-4889(97)00034-7. PMID 9268059.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
De SK, Venkateshan CN, Seth P et al. (1998). "Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines". Blood 91 (6): 2108–17. PMID 9490697.

PDB gallery

1fcg: ECTODOMAIN OF HUMAN FC GAMMA RECEPTOR, FCGRIIA

1h9v: HUMAN FC-GAMMA-RECEPTOR IIA (FCGRIIA), MONOCLINIC

2fcb: HUMAN FC GAMMA RECEPTOR IIB ECTODOMAIN (CD32)

External links

FCGR2A protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

FCGR2A

Interactions

See also

References

Further reading

External links