FBXO5

F-box protein 5

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2M6N

Identifiers

Symbols

FBXO5 ; EMI1; FBX5; Fbxo31

External IDs

OMIM: 606013 MGI: 1914391 HomoloGene: 8135 GeneCards: FBXO5 Gene

Gene ontology
Molecular function	• protein binding • protein kinase binding • metal ion binding
Cellular component	• nucleus • nucleoplasm • nucleolus • cytoplasm • spindle • cytosol
Biological process	• G1/S transition of mitotic cell cycle • regulation of transcription involved in G1/S transition of mitotic cell cycle • mitotic cell cycle • oocyte maturation • spindle assembly involved in female meiosis I • metaphase/anaphase transition of mitotic cell cycle • regulation of mitotic cell cycle • vesicle organization • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process • negative regulation of meiosis • microtubule polymerization • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • inhibition of mitotic anaphase-promoting complex activity
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
153.29 – 153.3 Mb

Chr 10:
5.8 – 5.81 Mb

PubMed search

F-box only protein 5 is a protein that in humans is encoded by the FBXO5 gene.^[1]^[2]^[3]

Function

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex.^[3]

Interactions

FBXO5 has been shown to interact with:

References

↑ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
↑ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
↑ 3.0 3.1 "Entrez Gene: FBXO5 F-box protein 5".
↑ 4.0 4.1 Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK (May 2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)". Nat. Cell Biol. 4 (5): 358–66. doi:10.1038/ncb785. PMID 11988738. Vancouver style error (help)
↑ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Oct 1999). "Identification of a family of human F-box proteins". Curr. Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.

Gubin AN, Njoroge JM, Bouffard GG, Miller JL (1999). "Gene expression in proliferating human erythroid cells". Genomics 59 (2): 168–77. doi:10.1006/geno.1999.5855. PMID 10409428.
Chiaur DS, Murthy S, Cenciarelli C, Parks W, Loda M, Inghirami G et al. (2000). "Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors". Cytogenet. Cell Genet. 88 (3–4): 255–8. doi:10.1159/000015532. PMID 10828603.
Reimann JD, Freed E, Hsu JY, Kramer ER, Peters JM, Jackson PK (2001). "Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex". Cell 105 (5): 645–55. doi:10.1016/S0092-8674(01)00361-0. PMID 11389834.
Reimann JD, Jackson PK (2002). "Emi1 is required for cytostatic factor arrest in vertebrate eggs". Nature 416 (6883): 850–4. doi:10.1038/416850a. PMID 11976684.
Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK (2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)". Nat. Cell Biol. 4 (5): 358–66. doi:10.1038/ncb785. PMID 11988738. Vancouver style error (help)
Li Z, Hu CY, Mo BQ, Xu JD, Zhao Y (2003). "[Effect of beta-carotene on gene expression of breast cancer cells]". Ai Zheng 22 (4): 380–4. PMID 12703993.
Margottin-Goguet F, Hsu JY, Loktev A, Hsieh HM, Reimann JD, Jackson PK (2003). "Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase". Dev. Cell 4 (6): 813–26. doi:10.1016/S1534-5807(03)00153-9. PMID 12791267.
Moshe Y, Boulaire J, Pagano M, Hershko A (2004). "Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome". Proc. Natl. Acad. Sci. U.S.A. 101 (21): 7937–42. doi:10.1073/pnas.0402442101. PMC 419535. PMID 15148369.
Hansen DV, Loktev AV, Ban KH, Jackson PK (2005). "Plk1 Regulates Activation of the Anaphase Promoting Complex by Phosphorylating and Triggering SCFβTrCP-dependent Destruction of the APC Inhibitor Emi1". Mol. Biol. Cell 15 (12): 5623–34. doi:10.1091/mbc.E04-07-0598. PMC 532041. PMID 15469984.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Eldridge AG, Loktev AV, Hansen DV, Verschuren EW, Reimann JD, Jackson PK (2006). "The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1". Cell 124 (2): 367–80. doi:10.1016/j.cell.2005.10.038. PMID 16439210.
Lehman NL, Verschuren EW, Hsu JY, Cherry AM, Jackson PK (2006). "Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells". Cell Cycle 5 (14): 1569–73. doi:10.4161/cc.5.14.2925. PMID 16861914.
Miller JJ, Summers MK, Hansen DV, Nachury MV, Lehman NL, Loktev A et al. (2006). "Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor". Genes Dev. 20 (17): 2410–20. doi:10.1101/gad.1454006. PMC 1560415. PMID 16921029.
Marangos P, Verschuren EW, Chen R, Jackson PK, Carroll J (2007). "Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APCCdh1". J. Cell Biol. 176 (1): 65–75. doi:10.1083/jcb.200607070. PMC 2063628. PMID 17190794.

FBXO5

Function

Interactions

References

Further reading