FBXO5

F-box protein 5
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsFBXO5 ; EMI1; FBX5; Fbxo31
External IDsOMIM: 606013 MGI: 1914391 HomoloGene: 8135 GeneCards: FBXO5 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez2627167141
EnsemblENSG00000112029ENSMUSG00000019773
UniProtQ9UKT4Q7TSG3
RefSeq (mRNA)NM_001142522NM_025995
RefSeq (protein)NP_001135994NP_080271
Location (UCSC)Chr 6:
153.29 – 153.3 Mb
Chr 10:
5.8 – 5.81 Mb
PubMed search

F-box only protein 5 is a protein that in humans is encoded by the FBXO5 gene.[1][2][3]

Function

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex.[3]

Interactions

FBXO5 has been shown to interact with:

References

  1. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
  2. Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
  3. 3.0 3.1 "Entrez Gene: FBXO5 F-box protein 5".
  4. 4.0 4.1 Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK (May 2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)". Nat. Cell Biol. 4 (5): 358–66. doi:10.1038/ncb785. PMID 11988738. Vancouver style error (help)
  5. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Oct 1999). "Identification of a family of human F-box proteins". Curr. Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.

Further reading