FBXL5

F-box and leucine-rich repeat protein 5

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3U9J, 3U9M, 3V5X, 3V5Y, 3V5Z

Identifiers

FBXL5 ; FBL4; FBL5; FLR1

External IDs

OMIM: 605655 MGI: 2152883 HomoloGene: 8129 GeneCards: FBXL5 Gene

Gene ontology
Molecular function	• ubiquitin-protein transferase activity • iron ion binding • protein binding
Cellular component	• ubiquitin ligase complex • SCF ubiquitin ligase complex • perinuclear region of cytoplasm
Biological process	• protein ubiquitination • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • iron ion homeostasis
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000118564

ENSMUSG00000039753

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
15.61 – 15.68 Mb

Chr 5:
43.74 – 43.82 Mb

PubMed search

F-box/LRR-repeat protein 5 is a protein that in humans is encoded by the FBXL5 gene.^[1]^[2]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternative splicing of this gene generates 2 transcript variants.^[2]

FBXL5 is an iron sensor. It promotes IRP2 ubiquitination and then its degradation.

References

↑ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
↑ 2.0 2.1 "Entrez Gene: FBXL5 F-box and leucine-rich repeat protein 5".

Further reading

Andersson B; Wentland MA; Ricafrente JY et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W; Andersson B; Worley KC et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Winston JT; Koepp DM; Zhu C et al. (1999). "A family of mammalian F-box proteins". Curr. Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
Ilyin GP, Rialland M, Pigeon C, Guguen-Guillouzo C (2001). "cDNA cloning and expression analysis of new members of the mammalian F-box protein family". Genomics 67 (1): 40–7. doi:10.1006/geno.2000.6211. PMID 10945468.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S; Weil B; Wellenreuther R et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S; Arlt D; Huber W et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF; Venkatesan K; Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Mehrle A; Rosenfelder H; Schupp I et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Zhang N; Liu J; Ding X et al. (2007). "FBXL5 interacts with p150Glued and regulates its ubiquitination". Biochem. Biophys. Res. Commun. 359 (1): 34–9. doi:10.1016/j.bbrc.2007.05.068. PMID 17532294.