FBLN1
| Fibulin 1 | |||||||||||||
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| Symbols | FBLN1 ; FBLN; FIBL1 | ||||||||||||
| External IDs | OMIM: 135820 MGI: 95487 HomoloGene: 21295 GeneCards: FBLN1 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 2192 | 14114 | |||||||||||
| Ensembl | ENSG00000077942 | ENSMUSG00000006369 | |||||||||||
| UniProt | P23142 | Q08879 | |||||||||||
| RefSeq (mRNA) | NM_001996 | NM_010180 | |||||||||||
| RefSeq (protein) | NP_001987 | NP_034310 | |||||||||||
| Location (UCSC) | Chr 22: 45.9 – 46 Mb | Chr 15: 85.21 – 85.29 Mb | |||||||||||
| PubMed search | |||||||||||||
FBLN1 is the gene encoding fibulin-1, an extracellular matrix and plasma protein.[1][2][3]
Function
Fibulin-1 is a secreted glycoprotein that is found in association with extracellular matrix structures including fibronectin-containing fibers, elastin-containing fibers and basement membranes. Fibulin-1 binds to a number of extracellular matrix constituents including fibronectin,[3] nidogen-1, and the proteoglycan, versican.[3][4] Fibulin-1 is also a blood protein capable of binding to fibrinogen.[5]
Structure
Fibulin-1 has modular domain structure and includes a series of nine epidermal growth factor-like modules followed by a fibulin-type module, a module found in all members of the fibulin gene family.[2]
The human fibulin-1 gene, FBLN1, encodes four splice variants designated fibulin-1A, B, C and D, which differ in their carboxy terminal regions. In mouse, chicken and the nematode, C. elegans, only two fibulin-1 variants are produced, fibulin-1C and fibulin-1D.[1]
Interactions
FBLN1 has been shown to interact with entactin,[6][7][8] NOV/CCN3,[9] amyloid precursor protein,[10] fibrinogen,[5] and fibronectin.[11]
See also
References
- ↑ 1.0 1.1 "Entrez Gene: FBLN1 fibulin 1".
- ↑ 2.0 2.1 Argraves WS, Tran H, Burgess WH, Dickerson K (December 1990). "Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure". J. Cell Biol. 111 (6 Pt 2): 3155–64. doi:10.1083/jcb.111.6.3155. PMC 2116371. PMID 2269669.
- ↑ 3.0 3.1 3.2 Balbona K, Tran H, Godyna S, Ingham KC, Strickland DK, Argraves WS (October 1992). "Fibulin binds to itself and to the carboxyl-terminal heparin-binding region of fibronectin". J. Biol. Chem. 267 (28): 20120–5. PMID 1400330.
- ↑ Timpl R, Sasaki T, Kostka G, Chu ML (June 2003). "Fibulins: a versatile family of extracellular matrix proteins". Nat. Rev. Mol. Cell Biol. 4 (6): 479–89. doi:10.1038/nrm1130. PMID 12778127.
- ↑ 5.0 5.1 Argraves, W. S.; Tanaka, A.; Smith, E. P.; Twal, W. O.; Argraves, K. M.; Fan, D.; Haudenschild, C. C. (2009). "Fibulin-1 and fibrinogen in human atherosclerotic lesions". Histochemistry and Cell Biology 132 (5): 559–565. doi:10.1007/s00418-009-0628-7. PMID 19693531.
- ↑ Adam, S; Göhring W; Wiedemann H; Chu M L; Timpl R; Kostka G (Sep 1997). "Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules". J. Mol. Biol. (ENGLAND) 272 (2): 226–36. doi:10.1006/jmbi.1997.1244. ISSN 0022-2836. PMID 9299350.
- ↑ Tran, H; VanDusen W J; Argraves W S (Sep 1997). "The self-association and fibronectin-binding sites of fibulin-1 map to calcium-binding epidermal growth factor-like domains". J. Biol. Chem. (UNITED STATES) 272 (36): 22600–6. doi:10.1074/jbc.272.36.22600. ISSN 0021-9258. PMID 9278415.
- ↑ Pan, T C; Kluge M; Zhang R Z; Mayer U; Timpl R; Chu M L (Aug 1993). "Sequence of extracellular mouse protein BM-90/fibulin and its calcium-dependent binding to other basement-membrane ligands". Eur. J. Biochem. (GERMANY) 215 (3): 733–40. doi:10.1111/j.1432-1033.1993.tb18086.x. ISSN 0014-2956. PMID 8354280.
- ↑ Perbal, B; Martinerie C; Sainson R; Werner M; He B; Roizman B (Feb 1999). "The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (3): 869–74. doi:10.1073/pnas.96.3.869. ISSN 0027-8424. PMC 15317. PMID 9927660.
- ↑ Ohsawa, I; Takamura C; Kohsaka S (Mar 2001). "Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function". J. Neurochem. (United States) 76 (5): 1411–20. doi:10.1046/j.1471-4159.2001.00144.x. ISSN 0022-3042. PMID 11238726.
- ↑ Balbona, K; Tran, H; Godyna, S; Ingham, KC; Strickland, DK; Argraves, WS (1992). "Fibulin binds to itself and to the carboxyl-terminal heparin-binding region of fibronectin.". The Journal of Biological Chemistry 267 (28): 20120–5. PMID 1400300.
Further reading
- Balbona K, Tran H, Godyna S et al. (1992). "Fibulin binds to itself and to the carboxyl-terminal heparin-binding region of fibronectin.". J. Biol. Chem. 267 (28): 20120–5. PMID 1400330.
- Argraves WS, Tran H, Burgess WH, Dickerson K (1991). "Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure.". J. Cell Biol. 111 (6 Pt 2): 3155–64. doi:10.1083/jcb.111.6.3155. PMC 2116371. PMID 2269669.
- Argraves WS, Dickerson K, Burgess WH, Ruoslahti E (1989). "Fibulin, a novel protein that interacts with the fibronectin receptor beta subunit cytoplasmic domain.". Cell 58 (4): 623–9. doi:10.1016/0092-8674(89)90097-4. PMID 2527614.
- Sasaki T, Göhring W, Pan TC et al. (1996). "Binding of mouse and human fibulin-2 to extracellular matrix ligands.". J. Mol. Biol. 254 (5): 892–9. doi:10.1006/jmbi.1995.0664. PMID 7500359.
- Roark EF, Keene DR, Haudenschild CC et al. (1995). "The association of human fibulin-1 with elastic fibers: an immunohistological, ultrastructural, and RNA study.". J. Histochem. Cytochem. 43 (4): 401–11. doi:10.1177/43.4.7534784. PMID 7534784.
- Tran H, Tanaka A, Litvinovich SV et al. (1995). "The interaction of fibulin-1 with fibrinogen. A potential role in hemostasis and thrombosis.". J. Biol. Chem. 270 (33): 19458–64. doi:10.1074/jbc.270.33.19458. PMID 7642629.
- Mattei MG, Pan TC, Zhang RZ et al. (1995). "The fibulin-1 gene (FBLN1) is located on human chromosome 22 and on mouse chromosome 15.". Genomics 22 (2): 437–8. doi:10.1006/geno.1994.1406. PMID 7806231.
- Korenberg JR, Chen XN, Tran H, Argraves WS (1995). "Localization of the human gene for fibulin-1 (FBLN1) to chromosome band 22q13.3.". Cytogenet. Cell Genet. 68 (3-4): 192–3. doi:10.1159/000133911. PMID 7842734.
- Brown JC, Wiedemann H, Timpl R (1994). "Protein binding and cell adhesion properties of two laminin isoforms (AmB1eB2e, AmB1sB2e) from human placenta.". J. Cell. Sci. 107 (1): 329–38. PMID 8175920.
- Pan TC, Kluge M, Zhang RZ et al. (1993). "Sequence of extracellular mouse protein BM-90/fibulin and its calcium-dependent binding to other basement-membrane ligands.". Eur. J. Biochem. 215 (3): 733–40. doi:10.1111/j.1432-1033.1993.tb18086.x. PMID 8354280.
- Clinton GM, Rougeot C, Derancourt J et al. (1996). "Estrogens increase the expression of fibulin-1, an extracellular matrix protein secreted by human ovarian cancer cells.". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 316–20. doi:10.1073/pnas.93.1.316. PMC 40229. PMID 8552629.
- Miosge N, Götz W, Sasaki T et al. (1996). "The extracellular matrix proteins fibulin-1 and fibulin-2 in the early human embryo.". Histochem. J. 28 (2): 109–16. doi:10.1007/BF02331415. PMID 8737292.
- Godyna S, Diaz-Ricart M, Argraves WS (1996). "Fibulin-1 mediates platelet adhesion via a bridge of fibrinogen.". Blood 88 (7): 2569–77. PMID 8839849.
- Tran H, Mattei M, Godyna S, Argraves WS (1997). "Human fibulin-1D: molecular cloning, expression and similarity with S1-5 protein, a new member of the fibulin gene family.". Matrix Biol. 15 (7): 479–93. doi:10.1016/S0945-053X(97)90021-4. PMID 9106159.
- Tran H, VanDusen WJ, Argraves WS (1997). "The self-association and fibronectin-binding sites of fibulin-1 map to calcium-binding epidermal growth factor-like domains.". J. Biol. Chem. 272 (36): 22600–6. doi:10.1074/jbc.272.36.22600. PMID 9278415.
- Adam S, Göhring W, Wiedemann H et al. (1997). "Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules.". J. Mol. Biol. 272 (2): 226–36. doi:10.1006/jmbi.1997.1244. PMID 9299350.
- Qing J, Maher VM, Tran H et al. (1997). "Suppression of anchorage-independent growth and matrigel invasion and delayed tumor formation by elevated expression of fibulin-1D in human fibrosarcoma-derived cell lines.". Oncogene 15 (18): 2159–68. doi:10.1038/sj.onc.1201385. PMID 9393974.
- Hayashido Y, Lucas A, Rougeot C et al. (1998). "Estradiol and fibulin-1 inhibit motility of human ovarian- and breast-cancer cells induced by fibronectin.". Int. J. Cancer 75 (4): 654–8. doi:10.1002/(SICI)1097-0215(19980209)75:4<654::AID-IJC26>3.0.CO;2-7. PMID 9466671.
- Roger P, Pujol P, Lucas A et al. (1998). "Increased immunostaining of fibulin-1, an estrogen-regulated protein in the stroma of human ovarian epithelial tumors.". Am. J. Pathol. 153 (5): 1579–88. doi:10.1016/S0002-9440(10)65746-X. PMC 1853396. PMID 9811350.
- Perbal B, Martinerie C, Sainson R et al. (1999). "The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling.". Proc. Natl. Acad. Sci. U.S.A. 96 (3): 869–74. doi:10.1073/pnas.96.3.869. PMC 15317. PMID 9927660.
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