FABP5

Fatty acid binding protein 5 (psoriasis-associated)

PDB rendering based on 1b56.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1B56, 1JJJ, 4AZM, 4AZR, 4LKP, 4LKT

Identifiers

Symbols

FABP5 ; E-FABP; EFABP; KFABP; PA-FABP; PAFABP

External IDs

OMIM: 605168 HomoloGene: 108238 IUPHAR: 2535 ChEMBL: 3674 GeneCards: FABP5 Gene

Gene ontology
Molecular function	• transporter activity • fatty acid binding • protein binding • lipid binding
Cellular component	• cytoplasm • extracellular vesicular exosome
Biological process	• glucose metabolic process • lipid metabolic process • phosphatidylcholine biosynthetic process • epidermis development • response to wounding • glucose transport
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
82.19 – 82.2 Mb

Chr 3:
10.01 – 10.02 Mb

PubMed search

Fatty acid-binding protein, epidermal is a protein that in humans is encoded by the FABP5 gene.^[1]^[2]

This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.^[2]

Interactions

FABP5 has been shown to interact with S100A7.^[3]^[4]

References

↑ Madsen P, Rasmussen HH, Leffers H, Honore B, Celis JE (Sep 1992). "Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins". J Invest Dermatol 99 (3): 299–305. doi:10.1111/1523-1747.ep12616641. PMID 1512466.
↑ 2.0 2.1 "Entrez Gene: FABP5 fatty acid binding protein 5 (psoriasis-associated)".
↑ Ruse, Monica; Broome Ann-Marie; Eckert Richard L (Jul 2003). "S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes". J. Invest. Dermatol. (United States) 121 (1): 132–41. doi:10.1046/j.1523-1747.2003.12309.x. ISSN 0022-202X. PMID 12839573.
↑ Hagens, G; Roulin K; Hotz R; Saurat J H; Hellman U; Siegenthaler G (Feb 1999). "Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales". Mol. Cell. Biochem. (NETHERLANDS) 192 (1–2): 123–8. doi:10.1023/A:1006894909694. ISSN 0300-8177. PMID 10331666.

Rasmussen HH, van Damme J, Puype M et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667.
Siegenthaler G, Hotz R, Chatellard-Gruaz D et al. (1994). "Purification and characterization of the human epidermal fatty acid-binding protein: localization during epidermal cell differentiation in vivo and in vitro". Biochem. J. 302 (2): 363–71. PMC 1137237. PMID 8092987.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Siegenthaler G, Hotz R, Chatellard-Gruaz D et al. (1993). "Characterization and expression of a novel human fatty acid-binding protein: the epidermal type (E-FABP)". Biochem. Biophys. Res. Commun. 190 (2): 482–7. doi:10.1006/bbrc.1993.1073. PMID 8427590.
Masouyé I, Saurat JH, Siegenthaler G (1996). "Epidermal fatty-acid-binding protein in psoriasis, basal and squamous cell carcinomas: an immunohistological study". Dermatology (Basel) 192 (3): 208–13. doi:10.1159/000246367. PMID 8726632.
Jaworski C, Wistow G (1997). "LP2, a differentiation-associated lipid-binding protein expressed in bovine lens". Biochem. J. 320 (1): 49–54. PMC 1217896. PMID 8947466.
Masouyé I, Hagens G, Van Kuppevelt TH et al. (1997). "Endothelial cells of the human microvasculature express epidermal fatty acid-binding protein". Circ. Res. 81 (3): 297–303. doi:10.1161/01.res.81.3.297. PMID 9285630.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Watanabe R, Fujii H, Yamamoto A et al. (1998). "Immunohistochemical distribution of cutaneous fatty acid-binding protein in human skin". J. Dermatol. Sci. 16 (1): 17–22. doi:10.1016/S0923-1811(97)00615-4. PMID 9438903.
Hagens G, Masouyé I, Augsburger E et al. (1999). "Calcium-binding protein S100A7 and epidermal-type fatty acid-binding protein are associated in the cytosol of human keratinocytes". Biochem. J. 339 (2): 419–27. doi:10.1042/0264-6021:3390419. PMC 1220173. PMID 10191275.
Hagens G, Roulin K, Hotz R et al. (1999). "Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales". Mol. Cell. Biochem. 192 (1–2): 123–8. doi:10.1023/A:1006894909694. PMID 10331666.
Hohoff C, Börchers T, Rüstow B et al. (1999). "Expression, purification, and crystal structure determination of recombinant human epidermal-type fatty acid binding protein". Biochemistry 38 (38): 12229–39. doi:10.1021/bi990305u. PMID 10493790.
O'Shaughnessy RF, Seery JP, Celis JE et al. (2001). "PA-FABP, a novel marker of human epidermal transit amplifying cells revealed by 2D protein gel electrophoresis and cDNA array hybridisation". FEBS Lett. 486 (2): 149–54. doi:10.1016/S0014-5793(00)02252-3. PMID 11113456.
Gutiérrez-González LH, Ludwig C, Hohoff C et al. (2002). "Solution structure and backbone dynamics of human epidermal-type fatty acid-binding protein (E-FABP)". Biochem. J. 364 (Pt 3): 725–37. doi:10.1042/BJ20020039. PMC 1222622. PMID 12049637.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Ruse M, Broome AM, Eckert RL (2003). "S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes". J. Invest. Dermatol. 121 (1): 132–41. doi:10.1046/j.1523-1747.2003.12309.x. PMID 12839573.
Ha MK, Chung KY, Lee JH et al. (2005). "Expression of psoriasis-associated fatty acid-binding protein in senescent human dermal microvascular endothelial cells". Exp. Dermatol. 13 (9): 543–50. doi:10.1111/j.0906-6705.2004.00196.x. PMID 15335354.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

PDB gallery

1b56: HUMAN RECOMBINANT EPIDERMAL FATTY ACID BINDING PROTEIN

1jjj: SOLUTION STRUCTURE OF RECOMBINANT HUMAN EPIDERMAL-TYPE FATTY ACID BINDING PROTEIN

Proteins: carrier proteins

Fatty acid

Hormone

Metal/element

calcium
- Calcium-binding protein
- Calmodulin-binding proteins
copper
- Ceruloplasmin
iron
- Iron-binding proteins
- Transferrin receptor

Vitamin

Retinol binding protein
- 1
- 2
- 3
- 4
Transcobalamin

Other

Index of proteins

Description	Proteins Membrane Globular enzymes carrier Antibodies Fibrous

FABP5

Interactions

References

Further reading