Excitatory amino-acid transporter 5
| Solute carrier family 1 (glutamate transporter), member 7 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | SLC1A7 ; AAAT; EAAT5 | ||||||||||||
| External IDs | OMIM: 604471 MGI: 2444087 HomoloGene: 21327 IUPHAR: 872 ChEMBL: 4390 GeneCards: SLC1A7 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 6512 | 242607 | |||||||||||
| Ensembl | ENSG00000162383 | ENSMUSG00000008932 | |||||||||||
| UniProt | O00341 | Q8JZR4 | |||||||||||
| RefSeq (mRNA) | NM_006671 | NM_146255 | |||||||||||
| RefSeq (protein) | NP_006662 | NP_666367 | |||||||||||
| Location (UCSC) | Chr 1: 53.55 – 53.61 Mb | Chr 4: 107.97 – 108.01 Mb | |||||||||||
| PubMed search | |||||||||||||
Excitatory amino-acid transporter 5 (EAAT5) is a protein that in humans is encoded by the SLC1A7 gene.[1][2]
EAAT5 is expressed predominantly in the retina, has high affinity for the excitatory amino acid L-glutamate. When stimulated by this amino acid, EAAT5 conducts chloride ions.[2]
References
- ↑ "Entrez Gene: solute carrier family 1 (glutamate transporter)".
- ↑ 2.0 2.1 Arriza JL, Eliasof S, Kavanaugh MP, Amara SG (April 1997). "Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance". Proc. Natl. Acad. Sci. U.S.A. 94 (8): 4155–60. doi:10.1073/pnas.94.8.4155. PMC 20584. PMID 9108121.
Further reading
- Strausberg RL, Feingold EA, Grouse LH et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wistow G, Bernstein SL, Ray S et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium.". Mol. Vis. 8: 185–95. PMID 12107412.
- Boehmer C, Rajamanickam J, Schniepp R et al. (2005). "Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3.". Biochem. Biophys. Res. Commun. 329 (2): 738–42. doi:10.1016/j.bbrc.2005.02.035. PMID 15737648.
- Gratacòs M, Costas J, de Cid R et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
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