Ethanolamide

Chemical structure of the ethanolamide anandamide

Ethanolamides are chemical compounds which are amides formed from carboxylic acids and ethanolamine. Some ethanolamides are naturally occurring, such as anandamide and palmitoylethanolamide, which play physiological roles as lipid neurotransmitters and autocoids.

The crystal structure of the membrane enzyme NAPE-PLD has revealed how these endogenous ethanolamides are generated from cell membranes, and that bile acids play a role in their production.[1]

Ethanolamides can be prepared synthetically by heating esters with ethanolamine.[2]

See also

References

  1. ↑ Magotti P, Bauer I, Igarashi M, Babagoli M, Marotta R, Piomelli D et al. (Dec 2014). "Structure of Human N-Acylphosphatidylethanolamine-Hydrolyzing Phospholipase D: Regulation of Fatty Acid Ethanolamide Biosynthesis by Bile Acids". Structure 24 (3). doi:10.1016/j.str.2014.12.018.
  2. ↑ Phillips, Arthur P. (1951). "Ethanolamides of Some Mono- and Dicarboxylic Acids". Journal of the American Chemical Society 73: 5557. doi:10.1021/ja01156a013.

External links

The dictionary definition of ethanolamides at Wiktionary