Escom
- Escom Ltd. - the German computer corporation
- Escom LLC - the Internet corporation
- ESCOM IPN - the Superior School of Computer Sciences of the National Polytechnic Institute of Mexico
- ESCOM - the French Ecole Supérieure de Chimie Organique et Minérale
- ESCOM - the name of the South African electricity public utility until 1986, when its name was changed to Eskom
- Electricity Supply Commission of Malawi (ESCOM) Ltd.
- ESCOM - the European Society for the Cognitive Sciences of Music
- Escom Group, a group of private investors in Angola