Epidemiology of leprosy

Worldwide, two to three million people are estimated to be permanently disabled because of leprosy.^[2] India has the greatest number of cases, with Brazil second and Indonesia third.

In 1999, the world incidence of Hansen's disease was estimated to be 640,000. In 2000, 738,284 cases were identified.^[3] In 2000, the World Health Organization (WHO) listed 91 countries in which Hansen's disease is endemic. India, Myanmar and Nepal contained 70% of cases. India reports over 50% of the world's leprosy cases.^[4] In 2002, 763,917 new cases were detected worldwide, and in that year the WHO listed Brazil, Madagascar, Mozambique, Tanzania and Nepal as having 90% of Hansen's disease cases.

According to recent figures from the WHO, new cases detected worldwide have decreased by approximately 107,000 cases (or 21%) from 2003 to 2004. This decreasing trend has been consistent for the past three years. In addition, the global registered prevalence of HD was 286,063 cases; 407,791 new cases were detected during 2004.

In the United States, Hansen's disease is tracked by the Centers for Disease Control and Prevention (CDC), with a total of 92 cases being reported in 2002.^[5] Although the number of cases worldwide continues to fall, pockets of high prevalence continue in certain areas such as Brazil, South Asia (India, Nepal), some parts of Africa (Tanzania, Madagascar, Mozambique) and the western Pacific.

Risk groups

At highest risk are those living in endemic areas with poor conditions such as inadequate bedding, contaminated water and insufficient diet, or other diseases (such as HIV) that compromise immune function. Recent research suggests that there is a defect in cell-mediated immunity that causes susceptibility to the disease. Less than ten percent of the world's population is actually capable of acquiring the disease.^[6]

The region of DNA responsible for this variability is also involved in Parkinson disease, giving rise to current speculation that the two disorders may be linked in some way at the biochemical level. In addition, men are twice as likely to contract leprosy as women. According to The Leprosy Mission Canada, most people—about 95% of the population—are naturally immune.^[6]

Disease burden

Although annual incidence—the number of new leprosy cases occurring each year—is important as a measure of transmission, it is difficult to measure in leprosy due to its long incubation period, delays in diagnosis after onset of the disease and the lack of laboratory tools to detect leprosy in its very early stages. Instead, the registered prevalence is used. Registered prevalence is a useful proxy indicator of the disease burden as it reflects the number of active leprosy cases diagnosed with the disease and receiving treatment with MDT at a given point in time. The prevalence rate is defined as the number of cases registered for MDT treatment among the population in which the cases have occurred, again at a given point in time.^[7]

New case detection is another indicator of the disease that is usually reported by countries on an annual basis. It includes cases diagnosed with onset of disease in the year in question (true incidence) and a large proportion of cases with onset in previous years (termed a backlog prevalence of undetected cases).

Endemic countries also report the number of new cases with established disabilities at the time of detection, as an indicator of the backlog prevalence. Determination of the time of onset of the disease is generally unreliable, is very labor-intensive and is seldom done in recording these statistics.

Global situation

Table 1: Prevalence at beginning of 2006, and trends in new case detection 2001-2005, and 2010, excluding Europe [registered prevalence is the national total of chronic cases]

Region	Registered prevalence (cases per 10,000 pop.)	New case detection during the year
	Start of 2006	2001	2002	2003	2004	2005	2010
Africa	40,830 (0.56)	39,612	48,248	47,006	46,918	42,814	25,345
Americas	32,904 (0.39)	42,830	39,939	52,435	52,662	41,780	37,740
South-East Asia	133,422 (0.81)	668,658	520,632	405,147	298,603	201,635	156,254
Eastern Mediterranean	4,024 (0.09)	4,758	4,665	3,940	3,392	3,133	4,080
Western Pacific	8,646 (0.05)	7,404	7,154	6,190	6,216	7,137	5,055
Totals	219,826	763,262	620,638	514,718	407,791	296,499	228,474

Table 2: Prevalence and detection, countries still to reach elimination. [registered prevalence is the national total of chronic cases]

Countries	Registered prevalence (cases per 10,000 pop.)			New case detection (rate/100,000 pop.)
	Start of 2004	Start of 2005	Start of 2006	During 2003	During 2004	During 2005
Brazil	79,908 (4.6)	30,693 (1.7)	27,313 (1.5)	49,206 (28.6)	49,384 (26.9)	38,410 (20.6)
Mozambique	6,810 (3.4)	4,692 (2.4)	4,889 (2.5)	5,907 (29.4)	4,266 (22.0)	5,371 (27.1)
Nepal	7,549 (3.1)	4,699 (1.8)	4,921 (1.8)	8,046 (32.9)	6,958 (26.2)	6,150 (22.7)
Tanzania	5,420 (1.6)	4,777 (1.3)	4,190 (1.1)	5,279 (15.4)	5,190 (13.8)	4,237 (11.1)
Totals	NA	NA	NA	NA	NA	NA

As reported to WHO by 115 countries and territories in 2006, and published in the Weekly Epidemiological Record, the global registered prevalence of leprosy at the beginning of the year was 219,826 cases.^[8] New-case detection during the previous year (2005 - the last year for which full country information is available) was 296,499. The reason for the annual detections being higher than the prevalence at the end of the year can be explained by the fact that a proportion of new cases complete their treatment within the year and, therefore, no longer remain on the registers. The global detection of new cases continues to show a sharp decline, falling by 110,000 cases (27%) during 2005 compared with the previous year.

Table 1 shows that global annual detection has been declining since 2001. The African region reported an 8.7% decline in the number of new cases compared with 2004. The comparable figure for the Americas was 20.1%, for South-East Asia 32%, and for the Eastern Mediterranean 7.6%. The Western Pacific area, however, showed a 14.8% increase during the same period.

Table 2 shows the leprosy situation in the four major countries that have yet to achieve the goal of elimination at the national level. It should be noted that: a) Elimination is defined as a prevalence of less than 1 case per 10,000 population; b) Madagascar reached elimination at the national level in September 2006; c) Nepal detection reported from mid-November 2004 to mid-November 2005; and d) D.R. Congo officially reported to WHO in 2008 that it had reached elimination by the end of 2007, at the national level.

People's Republic of China

The People's Republic of China has many leprosy recovered patients who have been isolated from the rest of society. In the 1950s the Chinese Communist government created "Recovered Villages" in rural remote mountaintops for the recovered patients. Although leprosy is now curable with the advent of the multi-drug treatment, the villagers remain because they have been stigmatized by the outside world. Health NGOs such as Joy in Action have arisen in China to especially focus on improving the conditions of "Recovered Villages".

Portugal

The Hospital-Colónia Rovisco Pais (the Rovisco Pais Hospital-Colony) was founded in Portugal in 1947 as a national center for the treatment of leprosy. It was renamed in 2007 as the Centro de Medicina de Reabilitação da Região Centro-Rovisco Pais. It still retains a leprosy service in which 25 ex patients live. Between 1988 and 2003 102 patients were treated in Portugal for leprosy.^[9]

Spain

The Sanatorio de Fontilles (Fontilles Sanatorium) in Spain was founded in 1902 and admitted its first patient in 1909. In 2002, the Sanatorio had 68 in-patients in the Sanatorium, and more than 150 receiving out-patient treatment. A small number of cases continue to be reported.^[10]

Greece

Two indigenous cases were reported from Greece in 2009.^[11]

France

One case was reported in France in 2009^[12]

Germany

Leprosy was almost eradicated in most of Europe by 1700 but sometime after 1850 leprosy was re introduced into East Prussia by Lithuanian rural workers immigrating from the Russian empire. The first leprosarium was founded in 1899 in Memel (now Klaipėda in Lithuania). Legislation was introduced in 1900 and 1904 requiring patients to be isolated and not allowed to work with others.

Great Britain

The last known case in Great Britain was acquired in 1901 in the Shetland Islands.

Malta

The first documented case of leprosy (erga corpore morbi leprae) in Malta in a Gozitan woman (Garita Xejbais) was in 1492 but it is certain that it was present on the island before this time.^[13] The next recorded case was in 1630 in a Dominican friar. A report in 1687 recorded five cases. A further three cases were reported in 1808. Between 1839 and 1858 an additional seven cases were recorded. In 1890 a population survey recorded a total of 69 cases. A later survey in 1957 identified 151 people infected with leprosy.

In June 1972 an eradication programme was started. The project was based on the work of Enno Freerksen, Director of the Borsal Institute in Hamburg. Dr Freerksen's earlier trial had used rifampacin, izoniazid, dapsone and prothionamide. The Malta project used rifampacin, dapsone and clofamazine. The project formally concluded in 1999 having treated about 300 patients.

Romania

The last leper colony in Europe is at Tichileşti, Romania. Until 1991 patients were not allowed to leave the colony. At this colony patients get food, a place to sleep, clothes and medical attention. Some live in long pavilions and others in houses with vegetable and flower gardens. There are two churches in the colony - Orthodox and Baptist - and a farm where the colony grows its own corn.

Canada

There were cases of leprosy in Atlantic Canada at the end of the 19th century, beginning in 1815.^[14] The patients were first housed on Sheldrake Island in the Miramichi River and later transferred to Tracadie. Catholic nuns (the religieuses hospitalières de Saint-Joseph, RHSJ) came to take care of the sick. They opened the first French-language hospital in New Brunswick and many more followed. Many hospitals opened by the RHSJ nuns are still in use today. The last hospital to house lepers in Tracadie was demolished in 1991. Its lazaretto section had been closed since 1965. In a century of existence, it had housed not only Acadian victims of the disease, but people from all over Canada as well as sick immigrants from Iceland, Russia and China, among other nations.^[15]

Cape Breton Island also suffered an outbreak, in the Lake Ainslie region. 9 persons were affected, but it died out soon after 1882. Another outbreak of 20 cases occurred in the Lake O'Law region around 1852.^[16]

United States

In the United States, the first definite reference to the disease was in Florida in 1758. In 2004, there were 131 total cases of the disease in the United States. Of the 131 cases, two-thirds were found to be males. Also out of the 131 cases, 25 were of individuals who were born in the country, which amounts to 19%. Mexico (18.3%), Micronesia (11.5%), Brazil (9.2%), and the Philippines (7.6%) were the next leading countries where the victims of the disease were originally born. A total of 20 cases were found to be white, not of Hispanic origin. As of October, 2005, 3,604 patients on the United States registry were currently receiving care.^[17] The disease is tracked by the Centers for Disease Control and Prevention (CDC), with a total of 166 new cases reported in the U.S. in 2005. Most (100 or 60%) of these new cases were reported in the following states; California, Louisiana, Massachusetts, New York, and Texas.^[18]

References

Global epidemiology of: Health topic Asthma Attention deficit hyperactivity disorder Autism Bed bugs Binge drinking Cancer breast Depression Diabetes mellitus Domestic violence Hepatitis C Herpes HIV/AIDS Leprosy Malnutrition Mental disorders child Motor vehicle collisions Obesity childhood Periodontal diseases Pneumonia Representations Schizophrenia Snakebites Suicide Syphilis Teenage pregnancy Tuberculosis