Entheogen

An entheogen ("generating the divine within")^[4] is a chemical substance used in a religious, shamanic, or spiritual context^[5] that may be synthesized or obtained from natural species. The chemical induces altered states of consciousness, psychological or physiological (e.g., bullet ant venom used by the Satere-Mawe people). Entheogens can supplement many diverse practices for transcendence, and revelation, including meditation, yoga, and prayer, psychedelic and visionary art, chanting, and music including peyote song and psytrance, traditional medicine and psychedelic therapy, witchcraft, magic, and psychonautics.

Entheogens have been used in a ritualized context for thousands of years; their religious significance is well established in anthropological and modern evidences. Examples of traditional entheogens include psychedelics like peyote, psilocybin mushrooms, and ayahuasca, psychedelic-dissociatives like Tabernanthe iboga, atypical psychedelics like Salvia divinorum, quasi-psychedelics like cannabis and Ipomoea tricolor, deliriants like Amanita muscaria. Traditionally a tea, admixture, or potion like ayahuasca or bhang have been compounded through the work of a shaman or apothecary.

With the advent of organic chemistry, there now exist many synthetic drugs with similar psychoactive properties, many derived from these plants. Many pure active compounds with psychoactive properties have been isolated from these respective organisms and chemically synthesized, including mescaline, psilocybin, DMT, salvinorin A, ibogaine, ergine, and muscimol. Semi-synthetic (e.g., LSD used by the Neo-American Church) and synthetic drugs (e.g., DPT used by the Temple of the True Inner Light and 2C-B used by the Sangoma) have also been developed.^[6] Cannabis is the world's most widely used psychedelic drug and part of the cannabis culture, while medical cannabis have contributed to the development of modern drug paraphernalia like the vaporizer used by hospitals. However, Cannabis is always considered a quasi-psychedelic drug, even with cannabis strains that have been bred to intensify the psychedelic characteristics.

More broadly, the term entheogen is used to refer to any psychoactive drugs when used for their religious or spiritual effects, whether or not in a formal religious or traditional structure. This terminology is often chosen to contrast with recreational use of the same drugs. Studies such as Timothy Leary's Marsh Chapel Experiment and Roland Griffiths' psilocybin studies at Johns Hopkins have documented reports of mystical/spiritual/religious experiences from participants who were administered psychoactive drugs in controlled trials. Ongoing research is limited due to widespread drug prohibition; however, some countries have legislation that allows for traditional entheogen use.

Etymology

The neologism entheogen was coined in 1979 by a group of ethnobotanists and scholars of mythology (Carl A. P. Ruck, Jeremy Bigwood, Danny Staples, Richard Evans Schultes, Jonathan Ott and R. Gordon Wasson). The term is derived from two words of ancient Greek, ἔνθεος (entheos) and γενέσθαι (genesthai). The adjective entheos translates to English as "full of the god, inspired, possessed", and is the root of the English word "enthusiasm." The Greeks used it as a term of praise for poets and other artists. Genesthai means "to come into being." Thus, an entheogen is a drug that causes one to become inspired or to experience feelings of inspiration, often in a religious or "spiritual" manner.^[7]

Entheogen was coined as a replacement for the terms hallucinogen and psychedelic. Hallucinogen was popularized by Aldous Huxley's experiences with mescaline, which were published as The Doors of Perception in 1954. Psychedelic, in contrast, is a Greek neologism for "mind manifest", and was coined by psychiatrist Humphry Osmond; Huxley was a volunteer in experiments Osmond was conducting on mescaline.

Ruck et al. argued that the term hallucinogen was inappropriate owing to its etymological relationship to words relating to delirium and insanity. The term psychedelic was also seen as problematic, owing to the similarity in sound to words pertaining to psychosis and also due to the fact that it had become irreversibly associated with various connotations of 1960s pop culture. In modern usage entheogen may be used synonymously with these terms, or it may be chosen to contrast with recreational use of the same drugs. The meanings of the term entheogen were formally defined by Ruck et al.:

In a strict sense, only those vision-producing drugs that can be shown to have figured in shamanic or religious rites would be designated entheogens, but in a looser sense, the term could also be applied to other drugs, both natural and artificial, that induce alterations of consciousness similar to those documented for ritual ingestion of traditional entheogens.

— Ruck et al, 1979, Journal of Psychedelic Drugs^[8]

Entheogens

Biota

In essence, all psychoactive drugs that are biosynthesized in nature by cytota (cellular life), can be used in an entheogenic context or with entheogenic intent. To exclude non-psychoactive drugs that sometimes also are used in spiritual context, the term "entheogen" refers primarily to drugs that have been categorized based on their historical use. Toxicity does not affect a drug's inclusion (some can kill humans), nor does effectiveness or potency (if a drug is psychoactive, and it has been used in a historical context, then the required dose has also been found).

High caffeine consumption has been linked to an increase in the likelihood of experiencing auditory hallucinations. A study conducted by the La Trobe University School of Psychological Sciences revealed that as few as five cups of coffee a day could trigger the phenomenon.^[9]

Common name	Fauna	Psychoactive constituent(s)	Regions/Cultures of use
Colorado River toad	Bufo alvarius	5-MeO-DMT and bufotenin	Controversial interpretation of Mesoamerican art.
Bullet ant	Paraponera clavata	Poneratoxin	Used by the Satere-Mawe people in their initiation rites 20 times.
Hallucinogenic fish	Primary Siganus spp.	Unknown
Common name	Flora	Psychoactive constituent(s)	Regions/Cultures of use
African dream root	Silene capensis	Possibly triterpenoid saponins	Xhosa people of South Africa.
Ayahuasca	Banisteriopsis caapi	Harmala alkaloids	South America; people of the Amazon Rainforest. UDV of Brazil and United States. Use within ayahuasca.
Blue lily	Nymphaea caerulea	Nuciferine and aporphine	Possibly ancient Egypt and South America.
Angel's trumpet	Brugmansia spp.	Tropane alkaloids	South America, sometimes used as part of ayahuasca.
Bolivian torch cactus	Echinopsis lageniformis syn. Trichocereus bridgesii	Mescaline	South America
Cannabis	Cannabis spp.	THC and other cannabinoids	Rastafari movements and other groups (see entheogenic use of cannabis)
Chaliponga	Diplopterys cabrerana	DMT, 5-MeO-DMT and bufotenin	Brazil, Colombia, Ecuador, and Peru as part of ayahuasca.
Harmal	Peganum harmala	Harmala alkaloids	Turkey and the Middle East.
Hawaiian baby woodrose	Argyreia nervosa	Ergoline alkaloids	Psychoactive, but may not have been used as an entheogen. Native to India. Traditional usage possible but mainly undocumented.
Henbane	Hyoscyamus niger	Tropane alkaloids	Ancient Greece and witches of the Middle Ages.
Peruvian torch cactus	Echinopsis peruviana syn. Trichocereus peruvianus	Mescaline	Pre-Incan Chavín rituals in Peru.
Iboga	Tabernanthe iboga	Ibogaine	Bwiti religion of West Central Africa. Used by Western nations to treat opioid addiction.
Morning glory	Ipomoea tricolor	Ergoline alkaloids	Aztecs
Morning glory	Ipomoea violacea	Ergoline alkaloids	Mazatec[10]
Jimson weed	Datura stramonium	Tropane alkaloids	Native Americans: Algonquian and Luiseño. Sadhus of India. Táltos of the Magyar (Hungary).
Jurema	Mimosa tenuiflora syn. M. hostilis	DMT and harmala alkaloids-ott claims to have taken bark alone and is active	Northeastern Brazil
Peyote	Lophophora williamsii	Mescaline	Native American Church, Oshara Tradition
Chacruna	Psychotria viridis	DMT	UDV of Peru, Ecuador, Colombia, and the Brazilian church. Santo Daime have used it as part of ayahuasca.
Ska María Pastora	Salvia divinorum	Salvinorin A	Mazatec
San Pedro cactus	Echinopsis pachanoi syn. Trichocereus pachanoi	Mescaline	South America
Christmas vine	Turbina corymbosa syn. Rivea corymbosa	Ergoline alkaloids	Mazatec[10]
Virola	Virola spp.	DMT, 5-MeO-DMT and bufotenin	South America
Vilca	Anadenanthera colubrina	DMT, 5-MeO-DMT and bufotenin	South America
Yopo	Anadenanthera peregrina	DMT, 5-MeO-DMT and bufotenin	South America
Common name	Fungi	Psychoactive constituent(s)	Regions/Cultures of use
Fly agaric	Amanita muscaria[11]	Ibotenic acid and muscimol	Siberian shamans. Scandinavia. Possibly the Soma drink of India.
Magic mushrooms	primarily Psilocybe spp.	Psilocybin and psilocin; baeocystin and norbaeocystin (some species)	Mazatec

Chemicals

Many man-made chemicals with little human history have been recognized to catalyze intense spiritual experiences, and many synthetic entheogens are simply slight modifications of their naturally occurring counterparts. Some synthetic entheogens like 4-AcO-DMT are theorized to be prodrugs that metabolize into the natural psychoactive, similar in nature to how the synthetic compound heroin is deacetylated by esterase to the active morphine. While synthesized DMT and mescaline is reported to have identical entheogenic qualities as extracted or plant based sources, the experience may wildly vary due to the lack of numerous psychoactive alkaloids that constitute the material. This is similar to how pure THC is very different than an extract that retains the many cannabinoids of the plant such as cannabidiol and cannabinol.

Common name	Synthesis process	Full name
LSD	Semi-synthetic	Lysergic acid diethylamide	New American Church believed "LSD is the true Christ".[12]
2C-B	Synthetic	2,5-dimethoxy-4-bromophenethylamine	2C-B is used by the Sangoma over their traditional plants.[6] Although acting strongly as an empathogen-entactogen, 2C-B is notably psychedelic in a unique way. Although some users feel the 2C-x series are better suited for recreational purposes, 2C-B is consistently excluded as an exception and is an exceptional example for its class.[13]
DPT	Synthetic	Dipropyltryptamine	DPT is used as a religious sacrament by the Temple of the True Inner Light who believes that DPT and other entheogens are physical manifestations of God.[14]
MDMA	Synthetic	3,4-methylenedioxy-N-methylamphetamine	Small doses of MDMA are used as an entheogen to enhance prayer or meditation by some religious practitioners.[15]
Psilocybin	Synthetic	4-Phosphoryloxy-N, N-Dimethyltryptamine	The Mazatec curandera María Sabina was celebrating a mushroom velada with pills of synthetic psilocybin named Indocybin synthesized by Albert Hofmann.[16]
Yohimbine	Synthetic or extracted	-	Yohimbine is an alkaloid naturally found in Pausinystalia yohimbe (Yohimbe), Rauwolfia serpentina (Indian Snakeroot), and Alchornea floribunda (Niando), along with several other active alkaloids. There are no references to these species in traditional use to induce past memories, most likely because their alkaloid content is too low; However, laboratory extracted yohimbine, now commonly sold as sport supplement, may be used in psychedelic therapy to facilitate recall of traumatic memories in the treatment of post traumatic stress disorder (PTSD).[17]

Controversial entheogens

L. E. Hollister's criteria for establishing that a drug is hallucinogenic is:^[18]

• in proportion to other effects, changes in thought, perception, and mood should predominate;
• intellectual or memory impairment should be minimal;
• stupor, narcosis, or excessive stimulation should not be an integral effect;
• autonomic nervous system side effects should be minimal; and
• addictive craving should be absent.

Most NMDA-antagonist dissociative drugs including ketamine, PCP, and DXM are drugs known to easily cause clinical psychological dependence, but also strengthen narcissism, and induces chemical dependence, and NMDA receptor antagonist neurotoxicity (NAN), when used chronically. Ketamine psychedelic therapy (KPT) have been used for preparation for death (thanatological, death-rebirth psychotherapy)^[19] chemical treatment against alcoholism, pain therapy, and to increase intelligence. However, ibogaine, is considered a non-controversial entheogen that also have been used for these purposes but is anti addictive, both against psychological dependence and chemical dependence.

Common recreational drugs that cause chemical dependence have a history of entheogenic use. Perhaps because they could not access traditional entheogens as shamans were very secret with their sacraments who regarded non-visioning sacraments as hedonistic. The drugs mentioned here have occasionally been used by some shamans but they are psychoactive drugs that are not classified as hallucinogens (psychedelic, dissociative or deliriant). These drugs are not researched chemicals for psychedelic therapy as they have low therapeutic index.

Common name	Source	Psychoactive constituent(s)	Regions/Cultures of use	Problematic use
Alcoholic beverages (e.g., wine)	Ethanol fermentation	Primarily ethyl alcohol	Used in rituals and worshipped by the Egyptians and the Greeks. Used (in the form of Communion wine) by Catholics and other Christian sects.	Physical dependence
Coca	Erythroxylum coca & Erythroxylum novogranatense spp.	Primarily cocaine	Coca has been a vital part of the religious cosmology of the Andean peoples of Peru, Bolivia, Ecuador, Colombia, northern Argentina, and Chile from the pre-Inca period through the present. In addition, coca use in shamanic rituals is well documented wherever local native populations have cultivated the plant. For example, the Tayronas of Colombia's Sierra Nevada de Santa Marta use to chew the plant before engaging in extended meditation and prayer.[20]	The alkaloid content of coca leaves is low, between 0.25% and 0.77%.[21] This means that chewing the leaves or drinking coca tea does not produce the intense high (euphoria, megalomania, depression) people experience with cocaine. However, even if it would produce such effect, the next problem would be cocaine dependence.
Kava	Piper methysticum	Kavalactones	Kava cultures are the religious and cultural traditions of western Oceania which consume kava.	Anxiolytic
Khat	Catha edulis		For centuries, religious leaders have consumed the leaves to stay awake during long nights of prayer.[22]	Khat can produce mild-to-moderate psychological dependence (less than tobacco or alcohol).[23]
Mapacho (South America) and thuoc lao (thuốc lào) (Vietnam)	Nicotiana rustica	Comparatively high levels of MAOI beta-carbolines	A common admixture of Ayahuasca in some parts of the Amazon.	Uncured tobacco contains nicotine which is addictive
Opium poppy	Papaver somniferum	Morphine	The opium poppy was a magical ritual plant among the Germanic tribes.[24]	Physical dependence

Religious use

Drugs, including some that cause physical dependence, have been used with entheogenic intention, mostly in ancient times.

Alcohol

Alcohol has sometimes been invested with religious significance.

The present day Arabic word for alcohol appears in The Qur'an (in verse 37:47) as الغول al-ġawl, properly meaning "spirit" or "demon", in the sense of "the thing that gives the wine its headiness."^[25] The term ethanol was invented 1838, modeled on German äthyl (Liebig), from Greek aither (see ether), and hyle "stuff". Ether in late 14c. meant "upper regions of space," from Old French ether and directly from Latin aether, "the upper pure, bright air," from Greek aither "upper air; bright, purer air; the sky," from aithein "to burn, shine," from PIE root *aidh- "to burn" (see edifice).^[26]

Celtic polytheism

In ancient Celtic religion, Sucellus or Sucellos was the god of agriculture, forests and alcoholic drinks of the Gauls.

Ancient Mesopotamian religion

Ninkasi is the ancient Sumerian tutelary goddess of beer.^[27]

Dionysian Mysteries

In the ancient Greco-Roman religion, Dionysos (or Bacchus) was the god of the grape harvest, winemaking and wine, of ritual madness and ecstasy, of merry making and theatre. The original rite of Dionysus is associated with a wine cult and he may have been worshipped as early as c. 1500–1100 BC by Mycenean Greeks. The Dionysian Mysteries were a ritual of ancient Greece and Rome which used intoxicants and other trance-inducing techniques (like dance and music) to remove inhibitions and social constraints, liberating the individual to return to a natural state. In his Laws, Plato said that alcoholic drinking parties should be the basis of any educational system, because the alcohol allows relaxation of otherwise fixed views. The Symposium (literally, 'drinking together') was a dramatised account of a drinking party where the participants debated the nature of love.

In the Homeric Hymn to Demeter, a cup of wine is offered to Demeter which she refuses, instead insisting upon a potion of barley, water, and glechon, known as the ceremonial drink Kykeon, an essential part of the Mysteries. The potion has been hypothesized to be an ergot derivative from barley, similar to LSD.^[28]

Osiris

Egyptian pictographs clearly show wine as a finished product around 4000 BC. Osiris, the god who invented beer and brewing, was worshiped throughout the country. The ancient Egyptians made at least 24 types of wine and 17 types of beer. These beverages were used for pleasure, nutrition, rituals, medicine, and payments. They were also stored in the tombs of the deceased for use in the afterlife.^[29] The Osirian Mysteries paralleled the Dionysian, according to contemporary Greek and Egyptian observers. Spirit possession involved liberation from civilization's rules and constraints. It celebrated that which was outside civilized society and a return to the source of being, which would later assume mystical overtones. It also involved escape from the socialized personality and ego into an ecstatic, deified state or the primal herd (sometimes both).

Other

Some scholars have postulated that pagan religions actively promoted alcohol and drunkenness as a means of fostering fertility. Alcohol was believed to increase sexual desire and make it easier to approach another person for sex. For example, Norse paganism considered alcohol to be the sap of Yggdrasil. Drunkenness was an important fertility rite in this religion.

Many Christian denominations use wine in the Eucharist or Communion and permit alcohol consumption in moderation. Other denominations use unfermented grape juice in Communion; they either voluntarily abstain from alcohol or prohibit it outright.

Judaism uses wine on Shabbat and some holidays for Kiddush as well as more extensively in the Passover ceremony and other religious ceremonies. The secular consumption of alcohol is allowed. Some Jewish texts, e.g., the Talmud, encourage moderate drinking on holidays (such as Purim) in order to make the occasion more joyous.

Kava culture

Kava cultures are the religious and cultural traditions of western Oceania which consume kava. There are similarities in the use of kava between the different cultures, but each one also has its own traditions.

Usage

Use and abuse

Entheogens have been used by individuals to pursue spiritual goals such as divination, Ego death, egolessness, faith healing, psychedelic therapy and spiritual formation.

There are also instances where people have been given entheogens without their knowledge or consent (e.g., tourists in Ayahuasca),^[30] as well as attempts to use such drugs in other contexts, such as cursing, psychochemical weaponry, psychological torture, brainwashing and mind control; CIA experiments with LSD were used in Project MKUltra, and controversial entheogens like alcohol are often mentioned in context of bread and circuses.

Cultural use

Entheogens have been used in various ways, e.g., as part of established religious rituals, as aids for personal spiritual development ("plant teachers"),^[31][32] as recreational drugs, and for medical and therapeutic use. The use of entheogens in human cultures is nearly ubiquitous throughout recorded history.

Naturally occurring entheogens such as psilocybin and DMT (in the preparation ayahuasca), were, for the most part, discovered and used by older cultures, as part of their spiritual and religious life, as plants and agents that were respected, or in some cases revered for generations and may be a tradition that predates all modern religions as a sort of proto-religious rite.

One of the most widely used entheogens is cannabis, entheogenic use of cannabis has been used in regions such as China, Europe, and India, and, in some cases, for thousands of years. It has also appeared as a part of religions and cultures such as the Rastafari movement, the Sadhus of Hinduism, the Scythians, Sufi Islam, and others.

Africa

The best-known entheogen-using culture of Africa is the Bwitists, who used a preparation of the root bark of Tabernanthe iboga.^[33] Although the ancient Egyptians may have been using the sacred blue lily plant in some of their religious rituals or just symbolically, it has been suggested that Egyptian religion once revolved around the ritualistic ingestion of the far more psychoactive Psilocybe cubensis mushroom, and that the Egyptian White Crown, Triple Crown, and Atef Crown were evidently designed to represent pin-stages of this mushroom.^[34] There is also evidence for the use of psilocybin mushrooms in Côte d'Ivoire.^[35] Numerous other plants used in shamanic ritual in Africa, such as Silene capensis sacred to the Xhosa, are yet to be investigated by western science. A recent revitalization has occurred in the study of southern African psychoactives and entheogens (Mitchell and Hudson 2004; Sobiecki 2002, 2008, 2012).^[36]

Americas

Entheogens have played a pivotal role in the spiritual practices of most American cultures for millennia. The first American entheogen to be subject to scientific analysis was the peyote cactus (Lophophora williamsii). For his part, one of the founders of modern ethno-botany, the late-Richard Evans Schultes of Harvard University documented the ritual use of peyote cactus among the Kiowa, who live in what became Oklahoma. While it was used traditionally by many cultures of what is now Mexico, in the 19th century its use spread throughout North America, replacing the deadly toxic mescal bean (Calia secundiflora) who are questioned to be an entheogen at all. Other well-known entheogens used by Mexican cultures include the alcoholic Aztec sacrament, pulque, ritual tobacco (known as 'picietl' to the Aztecs, and 'sikar' to the Maya (from where the word 'cigar' derives), psilocybin mushrooms, morning glories (Ipomoea tricolor and Turbina corymbosa), and Salvia divinorum.

Indigenous peoples of South America employ a wide variety of entheogens. Better-known examples include ayahuasca (most commonly Banisteriopsis caapi and Psychotria viridis) among indigenous peoples (such as the Urarina) of Peruvian Amazonia. Other entheogens include San Pedro cactus (Echinopsis pachanoi, syn. Trichocereus pachanoi), Peruvian torch cactus (Echinopsis peruviana, syn. Trichocereus peruvianus), and various DMT-snuffs, such as epená (Virola spp.), vilca and yopo (Anadenanthera colubrina and A. peregrina, respectively). The familiar tobacco plant, when used uncured in large doses in shamanic contexts, also serves as an entheogen in South America. Also, a tobacco that contains higher nicotine content, and therefore smaller doses required, called Nicotiana rustica was commonly used.

Entheogens also play an important role in contemporary religious movements such as the Rastafari movement and the Church of the Universe.

Datura wrightii is sacred to some native Americans and has been used in ceremonies and rites of passage by Chumash, Tongva, and others. Among the Chumash, when a boy was 8 years old, his mother would give him a preparation of momoy to drink. This supposed spiritual challenge should help the boy develop the spiritual wellbeing that is required to become a man. Not all of the boys undergoing this ritual survived.^[37] Momoy was also used to enhance spiritual wellbeing among adults . For instance, during a frightening situation, such as when seeing a coyote walk like a man, a leaf of momoy was sucked to help keep the soul in the body.

Asia

The indigenous peoples of Siberia (from whom the term shaman was borrowed) have used Amanita muscaria as an entheogen.

In Hinduism, Datura stramonium and cannabis have been used in religious ceremonies, although the religious use of datura is not very common, as the primary alkaloids are strong deliriants, which causes serious intoxication with unpredictable effects.

Also, the ancient drink Soma, mentioned often in the Vedas, appears to be consistent with the effects of an entheogen. In his 1967 book, Wasson argues that Soma was Amanita muscaria. The active ingredient of Soma is presumed by some to be ephedrine, an alkaloid with stimulant and (somewhat debatable) entheogenic properties derived from the soma plant, identified as Ephedra pachyclada. However, there are also arguments to suggest that Soma could have also been Syrian rue, cannabis, Atropa belladonna, or some combination of any of the above plants.

Europe

Fermented honey, known in Northern Europe as mead, was an early entheogen in Aegean civilization, predating the introduction of wine, which was the more familiar entheogen of the reborn Dionysus and the maenads. Its religious uses in the Aegean world are bound up with the mythology of the bee.

Dacians were known to use cannabis in their religious and important life ceremonies, proven by discoveries of large clay pots with burnt cannabis seeds in ancient tombs and religious shrines. Also, local oral folklore and myths tell of ancient priests that dreamed with gods and walked in the smoke. Their names, as transmitted by Herodotus, were "kap-no-batai" which in Dacian was supposed to mean "the ones that walk in the clouds".

The growth of Roman Christianity also saw the end of the two-thousand-year-old tradition of the Eleusinian Mysteries, the initiation ceremony for the cult of Demeter and Persephone involving the use of a drug known as kykeon. The term 'ambrosia' is used in Greek mythology in a way that is remarkably similar to the Soma of the Hindus as well.

A theory that natural occurring gases like ethylene used by inhalation may have played a role in divinatory ceremonies at Delphi in Classical Greece received popular press attention in the early 2000s, yet has not been conclusively proven.^[38]

Mushroom consumption is part of the culture of Europeans in general, with particular importance to Slavic and Baltic peoples. Some academics consider that using psilocybin- and or muscimol-containing mushrooms was an integral part of the ancient culture of the Rus' people.^[39]

Middle East

It has been suggested that the ritual use of small amounts of Syrian rue is an artifact of its ancient use in higher doses as an entheogen (possibly in conjunction with DMT containing acacia).

Philologist John Marco Allegro has argued in his book The Sacred Mushroom and the Cross that early Jewish and Christian cultic practice was based on the use of Amanita muscaria, which was later forgotten by its adherents. Allegro's hypothesis that Amanita use was forgotten after primitive Christianity seems contradicted by his own view that the Plaincourault Chapel shows evidence of Christian amanita use in the 13th century.^[40]

Oceania

In general, indigenous Australians are thought not to have used entheogens, although there is a strong barrier of secrecy surrounding Aboriginal shamanism, which has likely limited what has been told to outsiders. A plant that the Australian Aboriginals used to ingest is called Pitcheri, which is said to have a similar effect to that of coca. Pitcheri was made from the bark of the shrub Duboisia myoporoides. This plant is now grown commercially and is processed to manufacture an eye medication. There are no known uses of entheogens by the Māori of New Zealand aside from a variant species of Kava.^[41] Natives of Papua New Guinea are known to use several species of entheogenic mushrooms (Psilocybe spp, Boletus manicus).^[42]

Kava or kava kava (Piper Methysticum) has been cultivated for at least 3000 years by a number of Pacific island-dwelling peoples. Historically, most Polynesian, many Melanesian, and some Micronesian cultures have ingested the psychoactive pulverized root, typically taking it mixed with water. Much traditional usage of kava, though somewhat suppressed by Christian missionaries in the 19th and 20th centuries, is thought to facilitate contact with the spirits of the dead, especially relatives and ancestors.^[43]

Religious use

Prohibition

Some religions forbid, discourage, or restrict the drinking of alcoholic beverages. These include Islam, Jainism, the Bahá'í Faith, The Church of Jesus Christ of Latter-day Saints (LDS Church), the Seventh-day Adventist Church, the Church of Christ, Scientist, the United Pentecostal Church International, Theravada, most Mahayana schools of Buddhism, some Protestant denominations of Christianity, some sects of Taoism (Five Precepts and Ten Precepts), and Hinduism.

The Pali Canon, the scripture of Theravada Buddhism, depicts refraining from alcohol as essential to moral conduct because intoxication causes a loss of mindfulness. The fifth of the Five Precepts states, "Surā-meraya-majja-pamādaṭṭhānā veramaṇī sikkhāpadaṃ samādiyāmi." In English: "I undertake to refrain from fermented drink that causes heedlessness." Technically, this prohibition does not include other mind-altering drugs. The canon does not suggest that alcohol is evil but believes that the carelessness produced by intoxication creates bad karma. Therefore, any drug (beyond tea or mild coffee) that affects one's mindfulness be considered to be covered by this prohibition.

Judaism and Christianity

Many Christian denominations disapprove of the use of most illicit drugs. The early history of the Church, however, was filled with a variety of drug use, recreational and otherwise.^[44]

The primary advocate of a religious use of cannabis plant in early Judaism was Sula Benet, also called Sara Benetowa, a Polish anthropologist, who claimed in 1967 that the plant kaneh bosm קְנֵה-בֹשֶׂם mentioned five times in the Hebrew Bible, and used in the holy anointing oil of the Book of Exodus, was in fact cannabis.^[45] The Ethiopian Zion Coptic Church confirmed it as a possible valid interpretation.^[46] The lexicons of Hebrew and dictionaries of plants of the Bible such as by Michael Zohary (1985), Hans Arne Jensen (2004) and James A. Duke (2010) and others identify the plant in question as either Acorus calamus or Cymbopogon citratus.^[47] Kaneh-bosm is listed as an incense in the Old Testament. It is generally held by academics specializing in the archaeology and paleobotany of Ancient Israel, and those specializing in the lexicography of the Hebrew Bible that cannabis is not documented or mentioned in early Judaism. Against this some popular writers have argued that there is evidence for religious use of cannabis in the Hebrew Bible,^[48] although this hypothesis and some of the specific case studies (e.g., John Allegro in relation to Qumran, 1970) have been "widely dismissed as erroneous, others continue".^[49]

According to The Living Torah, cannabis may have been one of the ingredients of the holy anointing oil mentioned in various sacred Hebrew texts.^[50] The herb of interest is most commonly known as kaneh-bosm (Hebrew: קְנֵה-בֹשֶׂם). This is mentioned several times in the Old Testament as a bartering material, incense, and an ingredient in holy anointing oil used by the high priest of the temple. Although Chris Bennett's research in this area focuses on cannabis, he mentions evidence suggesting use of additional visionary plants such as henbane, as well.^[51]

The Septuagint translates kaneh-bosm as calamus, and this translation has been propagated unchanged to most later translations of the old testament. However, Polish anthropologist Sula Benet published etymological arguments that the Aramaic word for hemp can be read as kannabos and appears to be a cognate to the modern word 'cannabis',^[52] with the root kan meaning reed or hemp and bosm meaning fragrant. Both cannabis and calamus are fragrant, reedlike plants containing psychotropic compounds.

In his research, Professor Dan Merkur points to significant evidence of an awareness within the Jewish mystical tradition recognizing manna as an entheogen, thereby substantiating with rabbinic texts theories advanced by the superficial biblical interpretations of Terence McKenna, R. Gordon Wasson and other ethnomycologists.

Although philologist John Marco Allegro has suggested that the self-revelation and healing abilities attributed to the figure of Jesus may have been associated with the effects of the plant medicines, this evidence is dependent on pre-Septuagint interpretation of Torah and Tenach. Allegro was the only non-Catholic appointed to the position of translating the Dead Sea scrolls. His extrapolations are often the object of scorn due to Allegro's non-mainstream theory of Jesus as a mythological personification of the essence of a "psychoactive sacrament". Furthermore, they conflict with the position of the Catholic Church with regard to transubstantiation and the teaching involving valid matter, form, and drug — that of bread and wine (bread does not contain psychoactive drugs, but wine contains ethanol). Allegro's book The Sacred Mushroom and the Cross relates the development of language to the development of myths, religions, and cultic practices in world cultures. Allegro believed he could prove, through etymology, that the roots of Christianity, as of many other religions, lay in fertility cults, and that cult practices, such as ingesting visionary plants (or "psychedelics") to perceive the mind of God, persisted into the early Christian era, and to some unspecified extent into the 13th century with reoccurrences in the 18th century and mid-20th century, as he interprets the Plaincourault chapel's fresco to be an accurate depiction of the ritual ingestion of Amanita muscaria as the Eucharist.

The historical picture portrayed by the Entheos journal is of fairly widespread use of visionary plants in early Christianity and the surrounding culture, with a gradual reduction of use of entheogens in Christianity.^[53] R. Gordon Wasson's book Soma prints a letter from art historian Erwin Panofsky asserting that art scholars are aware of many "mushroom trees" in Christian art.^[54]

The question of the extent of visionary plant use throughout the history of Christian practice has barely been considered yet by academic or independent scholars. The question of whether visionary plants were used in pre-Theodosius Christianity is distinct from evidence that indicates the extent to which visionary plants were utilized or forgotten in later Christianity, including so-called "heretical" or "quasi-" Christian groups,^[55] and the question of other groups such as elites or laity within "orthodox" Catholic practice.^[56]

Daniel Merkur at the University of Toronto contends that a minority of Christian hermits and mystics could possibly have used entheogens, in conjunction with fasting, meditation, and prayer.

Archaeological record

R. Gordon Wasson and Giorgio Samorini have proposed several examples of the cultural use of entheogens that are found in the archaeological record.^[57][58] Evidence for the first use of entheogens may come from Tassili, Algeria, with a cave painting of a mushroom-man, dating to 8000 BP. Hemp seeds discovered by archaeologists at Pazyryk suggest early ceremonial practices by the Scythians occurred during the 5th to 2nd century BC, confirming previous historical reports by Herodotus.

Classical mythology and cults

Although entheogens are taboo and most of them are officially prohibited in Christian and Islamic societies, their ubiquity and prominence in the spiritual traditions of various other cultures is unquestioned. "The spirit, for example, need not be chemical, as is the case with the ivy and the olive: and yet the god was felt to be within them; nor need its possession be considered something detrimental, like drugged, hallucinatory, or delusionary: but possibly instead an invitation to knowledge or whatever good the god's spirit had to offer."^[59]

Most of the well-known modern examples, such as peyote, psilocybin mushrooms, and morning glories are from the native cultures of the Americas. However, it has also been suggested that entheogens played an important role in ancient Indo-European culture, for example by inclusion in the ritual preparations of the Soma, the "pressed juice" that is the subject of Book 9 of the Rig Veda. Soma was ritually prepared and drunk by priests and initiates and elicited a paean in the Rig Veda that embodies the nature of an entheogen:

Splendid by Law! declaring Law, truth speaking, truthful in thy works, Enouncing faith, King Soma!... O [Soma] Pavāmana (mind clarifying), place me in that deathless, undecaying world wherein the light of heaven is set, and everlasting lustre shines.... Make me immortal in that realm where happiness and transports, where joy and felicities combine...

The kykeon that preceded initiation into the Eleusinian Mysteries is another entheogen, which was investigated (before the word was coined) by Carl Kerényi, in Eleusis: Archetypal Image of Mother and Daughter. Other entheogens in the Ancient Near East and the Aegean include the opium poppy, datura, and the unidentified "lotus" (likely the sacred blue lily) eaten by the Lotus-Eaters in the Odyssey and Narcissus.

According to Ruck, Eyan, and Staples, the familiar shamanic entheogen that the Indo-Europeans brought knowledge of was Amanita muscaria. It could not be cultivated; thus it had to be found, which suited it to a nomadic lifestyle. When they reached the world of the Caucasus and the Aegean, the Indo-Europeans encountered wine, the entheogen of Dionysus, who brought it with him from his birthplace in the mythical Nysa, when he returned to claim his Olympian birthright. The Indo-European proto-Greeks "recognized it as the entheogen of Zeus, and their own traditions of shamanism, the Amanita and the 'pressed juice' of Soma — but better, since no longer unpredictable and wild, the way it was found among the Hyperboreans: as befit their own assimilation of agrarian modes of life, the entheogen was now cultivable."^[59] Robert Graves, in his foreword to The Greek Myths, hypothesises that the ambrosia of various pre-Hellenic tribes was Amanita muscaria (which, based on the morphological similarity of the words amanita, amrita and ambrosia, is entirely plausible) and perhaps psilocybin mushrooms of the Panaeolus genus.

Amanita was divine food, according to Ruck and Staples, not something to be indulged in or sampled lightly, not something to be profaned. It was the food of the gods, their ambrosia, and it mediated between the two realms. It is said that Tantalus's crime was inviting commoners to share his ambrosia.

The entheogen is believed to offer godlike powers in many traditional tales, including immortality. The failure of Gilgamesh in retrieving the plant of immortality from beneath the waters teaches that the blissful state cannot be taken by force or guile: When Gilgamesh lay on the bank, exhausted from his heroic effort, the serpent came and ate the plant.

Another attempt at subverting the natural order is told in a (according to some) strangely metamorphosed myth, in which natural roles have been reversed to suit the Hellenic world-view. The Alexandrian Apollodorus relates how Gaia (spelled "Ge" in the following passage), Mother Earth herself, has supported the Titans in their battle with the Olympian intruders. The Giants have been defeated:

When Ge learned of this, she sought a drug that would prevent their destruction even by mortal hands. But Zeus barred the appearance of Eos (the Dawn), Selene (the Moon), and Helios (the Sun), and chopped up the drug himself before Ge could find it.^[60]

Assassins

The legends of the Assassins had much to do with the training and instruction of Nizari fida'is, famed for their public missions during which they often gave their lives to eliminate adversaries.

The tales of the fida’is’ training collected from anti-Ismaili historians and orientalists writers were confounded and compiled in Marco Polo’s account, in which he described a "secret garden of paradise". After being drugged, the Ismaili devotees were said be taken to a paradise-like garden filled with attractive young maidens and beautiful plants in which these fida’is would awaken. Here, they were told by an "old" man that they were witnessing their place in Paradise and that should they wish to return to this garden permanently, they must serve the Nizari cause.^[61] So went the tale of the "Old Man in the Mountain", assembled by Marco Polo and accepted by Joseph von Hammer-Purgstall (1774–1856), a prominent orientalist writer responsible for much of the spread of this legend. Until the 1930s, von Hammer’s retelling of the Assassin legends served as the standard account of the Nizaris across Europe.

Research

Notable early testing of the entheogenic experience includes the Marsh Chapel Experiment, conducted by physician and theology doctoral candidate, Walter Pahnke, under the supervision of Timothy Leary and the Harvard Psilocybin Project. In this double-blind experiment, volunteer graduate school divinity students from the Boston area almost all claimed to have had profound religious experiences subsequent to the ingestion of pure psilocybin. In 2006, a more rigorously controlled experiment was conducted at Johns Hopkins University, and yielded similar results.^[62] To date there is little peer-reviewed research on this subject, due to ongoing drug prohibition and the difficulty of getting approval from institutional review boards.^[63]

Furthermore, scientific studies on entheogens present some significant challenges to investigators, including philosophical questions relating to ontology, epistemology and objectivity.^[64]

Legal status of entheogens

Australia

Between 2011 and 2012, the Australian Federal Government was considering changes to the Australian Criminal Code that would classify any plants containing any amount of DMT as "controlled plants".^[65] DMT itself was already controlled under current laws. The proposed changes included other similar blanket bans for other substances, such as a ban on any and all plants containing Mescaline or Ephedrine. The proposal was not pursued after political embarrassment on realisation that this would make the official Floral Emblem of Australia, Acacia pycnantha (Golden Wattle), illegal. The Therapeutic Goods Administration and federal authority had considered a motion to ban the same, but this was withdrawn in May 2012 (as DMT may still hold potential entheogenic value to native and/or religious peoples).^[66]

United States

In 1963 in Sherbert v. Verner the Supreme Court established the Sherbert Test, which consists of four criteria that are used to determine if an individual's right to religious free exercise has been violated by the government. The test is as follows:

For the individual, the court must determine

• whether the person has a claim involving a sincere religious belief, and
• whether the government action is a substantial burden on the person’s ability to act on that belief.

If these two elements are established, then the government must prove

• that it is acting in furtherance of a "compelling state interest," and
• that it has pursued that interest in the manner least restrictive, or least burdensome, to religion.

This test was eventually all-but-eliminated in Employment Division v. Smith 494 U.S. 872 (1990), but was resurrected by Congress in the federal Religious Freedom Restoration Act (RFRA) of 1993.

In City of Boerne v. Flores, 521 U.S. 507 (1997) and Gonzales v. O Centro Espírita Beneficente União do Vegetal, 546 U.S. 418 (2006), the RFRA was held to trespass on state sovereignty, and application of the RFRA was essentially limited to federal law enforcement.

As of 2001, Arizona, Idaho, New Mexico, Oklahoma, South Carolina, and Texas had enacted so-called "mini-RFRAs."

Literature

Many works of literature have described entheogen use; some of those are:

• The drug melange (spice) in Frank Herbert's Dune universe acts as both an entheogen (in large enough quantities) and an addictive geriatric medicine. Control of the supply of melange was crucial to the Empire, as it was necessary for, among other things, faster-than-light (folding space) navigation.
• Consumption of the imaginary mushroom anochi [enoki] as the entheogen underlying the creation of Christianity is the premise of Philip K. Dick's last novel, The Transmigration of Timothy Archer, a theme that seems to be inspired by John Allegro's book.
• Aldous Huxley's final novel, Island (1962), depicted a fictional psychoactive mushroom — termed "moksha medicine" — used by the people of Pala in rites of passage, such as the transition to adulthood and at the end of life.
• Bruce Sterling's Holy Fire novel refers to the religion in the future as a result of entheogens, used freely by the population.
• In Stephen King's The Dark Tower: The Gunslinger, Book 1 of The Dark Tower series, the main character receives guidance after taking mescaline.
• The Alastair Reynolds novel Absolution Gap features a moon under the control of a religious government that uses neurological viruses to induce religious faith.
• A critical examination of the ethical and societal implications and relevance of "entheogenic" experiences can be found in Daniel Waterman and Casey William Hardison's book Entheogens, Society & Law: Towards a Politics of Consciousness, Autonomy and Responsibility (Melrose, Oxford 2013). This book includes a controversial analysis of the term entheogen arguing that Wasson et al. were mystifying the effects of the plants and traditions it refers to.
• The book Orange Sunshine and the Psychedelic Sunrise covers the continuum of life to death experiences from a personal and existential perspective, with an emphasis on spiritual transcendence: a psychedelic experience.

See also

• Betty Eisner
• Entheogenic use of cannabis
• Hallucinogenic fish
• Heffter Research Institute
• Sacred herbs

References

Further reading

External links

• The Vaults of Erowid (Erowid)
• Entheogenreview.com Quarterly publication that served as a clearinghouse for current data about the use of visionary plants and drugs.
• Council on Spiritual Practices Entheogen Project
• Religion and Psychoactive Sacraments: An Entheogen Chrestomathy
• Manual for Ibogaine Therapy Contributing Authors : Marc Emery, Geerte Frenken, Sara Glatt, Brian Mariano, Karl Naeher, Dr. Martin Polanco, Marko Resinovic, Nick Sandberg, Eric Taub, Samuel Waizmann and Hattie Wells
• Trips Beyond Addiction (Jan 2013) Living Hero Radio Show and Podcast special. The voices of ex-addicts, researchers from MAPS and Ibogaine/Iboga/Ayahuasca treatment providers sharing their experiences in breaking addiction with native medicines
• Cross-cultural Perspectives on the Uses of Stimulants as Entheogens Des Tramacchi's lectures in Entheogenesis Australis 2010 symposium.

Hallucinogens Psychedelics 5-HT2AR agonists Lysergamides AL-LAD ALD-52 BU-LAD IP-LAD Diallyllysergamide Dimethyllysergamide Ergometrine ETH-LAD LAE-32 LPD-824 LSA LSD LSD-Pip LSH LSM-775 2-Butyllysergamide LSZ 3-Pentyllysergamide Methylergometrine Methylisopropyllysergamide Methysergide MLD-41 PARGY-LAD PRO-LAD Phenethylamines Aleph 2-Methyl-MDA 2C-B 2C-B-AN 2C-B-Dragonfly 2C-B-FLY 2CB-Ind βk-2C-B 2C-C 2C-C-FLY 2C-CP 25C-NBOMe 25CN-NBOH 25CN-NBOMe 25D-NBOMe 2C-D 2C-D-FLY 2C-E 2C-E-FLY 25E-NBOMe 2C-EF 2C-F 25F-NBOMe 2C-G 25G-NBOMe 25H-NBOMe 2C-I βk-2C-I 2C-iP 2C-I-FLY 2C-N 25N-NBOMe 2C-O 2C-O-4 2C-P 2C-T 2C-T-2 2C-T-3 2C-T-4 25T4-NBOMe 2C-T-7 2C-T-7-FLY 25T7-NBOH 2C-T-8 2C-T-13 2C-T-15 2C-T-16 2C-T-17 2C-T-19 2C-T-21 2C-T-21.5 2C-T-22 2C-T-27 2C-T-28 2C-TFE 2C-TFM 25TFM-NBOMe 2C-V 2C-YN 2CBCB-NBOMe 2CBFly-NBOMe 2CD-5EtO 25B-NBOMe 25B-NBOH 25C-NBOH 25I-NBMD 25I-NBOH 25I-NBF 25I-NBOMe 25P-NBOMe 3C-AL 3C-DFE 3C-E 3C-P 3C-TFE 4C-B 4C-D 5-APB 5-APDB 5-APDI 5-Methyl-MDA 6-APB 6-APDB 6-Methyl-MDA Br-DFLY Difluoroescaline Difluoromescaline DESOXY DMBMPP DMMDA DMMDA-2 DOB DOB-FLY DOC DOEF DOET DOF DOI DOM DOM-FLY DON DOPR DOTFM DOYN BOB BOD BMB Escaline Fluoroproscaline Ganesha HOT-2 HOT-7 HOT-17 Isoproscaline Jimscaline Lophophine Macromerine MDA MDEA MDMA Mescaline Mescaline-NBOMe Methallylescaline MMA MMDA MMDA-2 MMDA-3a MMDMA Proscaline TCB-2 TFMFly Trifluoroescaline Trifluoromescaline TMA Piperazines pFPP TMFPP mCPP Tryptamines 1-Me-5-MeO-DiPT 2,N,N-TMT 4,5-DHP-α-MT 4,5-DHP-DMT 4-AcO-DALT 4-AcO-DET 4-AcO-DiPT 4-AcO-DMT 4-AcO-DPT 4-AcO-MiPT 4-HO-5-MeO-DMT 4-HO-DBT 4-HO-DPT 4-HO-MET 4-HO-MPMI 4-HO-MPT 4,N,N-TMT 4-Propionyloxy-DMT 5,6-diBr-DMT 5-AcO-DMT 5-Bromo-DMT 5-Me-MIPT 5-MeO-2,N,N-TMT 5-MeO-4,N,N-TMT 5-MeO-α,N,N-TMT 5-MeO-α-ET 5-MeO-α-MT 5-MeO-DALT 5-MeO-DET 5-MeO-DiPT 5-MeO-DMT 5-MeO-DPT 5-MeO-EiPT 5-MeO-MET 5-MeO-MiPT 5-MeO-MPMI 5-N,N-TMT 7,N,N-TMT α-ET α-MT α,N,N-TMT Aeruginascin Baeocystin Bufotenin DALT DBT DCPT DET DIPT DMT DPT EiPT Ethocin Ethocybin Ibogaine Iprocin MET Miprocin MiPT Norbaeocystin Noribogaine PiPT Psilocin Psilocybin Voacangine Others AL-38022A ALPHA Dimemebfe M-ALPHA RH-34 Dissociatives NMDAR antagonists Adamantanes Amantadine Memantine Rimantadine Arylcyclohexylamines 3-MeO-PCP 4-MeO-PCP Dieticyclidine Esketamine Ethketamine Eticyclidine Gacyclidine Ketamine Methoxetamine Methoxyketamine PCPr Phencyclidine Rolicyclidine Tenocyclidine Tiletamine Morphinans Dextrallorphan Dextromethorphan Dextrorphan Racemethorphan Racemorphan Others 2-MDP 8A-PDHQ Aptiganel Dexoxadrol Diphenidine Dizocilpine Etoxadrol Ibogaine Methoxphenidine Midafotel NEFA Neramexane Nitrous oxide Noribogaine Perzinfotel Remacemide Selfotel Xenon Deliriants mAChR antagonists Atropine Benactyzine Benzatropine Benzydamine Biperiden BRN-1484501 Brompheniramine BZ CAR-226,086 CAR-301,060 CAR-302,196 CAR-302,282 CAR-302,368 CAR-302,537 CAR-302,668 Chloropyramine Chlorphenamine Clemastine CS-27349 Cyclizine Cyproheptadine Dicycloverine Dimenhydrinate Diphenhydramine Ditran Doxylamine EA-3167 EA-3443 EA-3580 EA-3834 Elemicin Flavoxate Hyoscyamine JB-318 JB-336 Meclozine Mepyramine Myristicin Orphenadrine Oxybutynin Pheniramine Phenyltoloxamine Procyclidine Promethazine Scopolamine Tolterodine Trihexyphenidyl Tripelennamine Triprolidine WIN-2299 Miscellaneous Cannabinoids CB1R agonists Phytocannabinoids Cannabinol THC (Dronabinol) THCV (Cannabidiol has different mechanism of action) Synthetic 4-HTMPIPO 5F-PB-22 AB-001 AB-005 A-836,339 AB-CHMINACA AB-FUBINACA AB-PINACA ADB-FUBINACA ADB-PINACA ADBICA AM-630 AM-679 AM-694 AM-1220 AM-1221 AM-1235 AM-1241 AM-1248 AM-2201 AM-2232 AM-2233 APICA APINACA CB-13 CP 47,497 CP 55,244 CP 55,940 DMHP HU-210 HU-308 JWH-007 JWH-015 JWH-018 JWH-019 JWH-030 JWH-073 JWH-081 JWH-098 JWH-116 JWH-122 JWH-149 JWH-167 JWH-182 JWH-193 JWH-198 JWH-200 JWH-203 JWH-210 JWH-250 JWH-251 JWH-398 JWH-424 JTE 7-31 JTE-907 Levonantradol MAM-2201 MDA-19 MN-25 NESS-0327 NESS-040C5 Nabilone Nabitan Org 28611 Parahexyl QUCHIC QUPIC RCS-4 RCS-8 SDB-006 STS-135 THC-O-acetate THC-O-phosphate UR-144 WIN 55,212-2 XLR-11 D2R agonists Apomorphine Aporphine Bromocriptine Cabergoline Lisuride Memantine Nuciferine Pergolide Piribedil Pramipexole Ropinirole Rotigotine Also indirect D2 agonists, such as dopamine reuptake inhibitors (cocaine, methylphenidate), releasing agents (amphetamine, methamphetamine), and precursors (levodopa). GABAAR agonists Eszopiclone Gaboxadol Ibotenic acid Muscimol Zaleplon Zolpidem Zopiclone Inhalants Mixed MOA Aliphatic hydrocarbons Butane Gasoline Kerosene Propane Aromatic hydrocarbons Toluene Ethers Diethyl ether Enflurane Haloalkanes Chlorofluorocarbons Chloroform κOR agonists 2-EMSB 2-MMSB Alazocine Bremazocine Butorphanol Cyclazocine Cyprenorphine Dextrallorphan Dezocine Enadoline Herkinorin HZ-2 Ibogaine Ketazocine LPK-26 Metazocine Nalbuphine Nalorphine Noribogaine Pentazocine Phenazocine Salvinorin A Spiradoline Tifluadom U-50488 U-69,593 MAO inhibitors Harmaline Harmine Tetrahydroharmine Yohimbine σR agonists DMT Dextrallorphan Dextromethorphan Dextrorphan Noscapine Others Glaucine Isoaminile Pukateine

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Witchcraft and magic Types African witchcraft Vodun Witch smeller Asian witchcraft Kulam Onmyōdō Australasian witchcraft Makutu European witchcraft Akelarre Benandanti Brujería Cunning folk Seiðr Völva White witch Witch-cult hypothesis North American witchcraft 21 Divisiones Granny woman Hoodoo Huna Pow-wow Santería Vodou Voodoo South American witchcraft Candomblé Contemporary witchcraft Feri Tradition Kitchen witchcraft Stregheria Wicca Practices Animism Coven Demon Divination Entheogen Evocation Familiar spirit Flying ointment Jinn Magic Necromancy Occultism Poppet Potions Prayer Satanic ritual abuse Satanism Shamanism Sigils Spiritism Spiritualism Witch ball Witch's ladder Objects Amulet Broom Cloak of invisibility Magic carpet Magic ring Magic sword Talisman Wand Folklore and mythology Agamede Aradia Baba Yaga Daayan Drude Elbow witch Huld Kalku Hecate Circe Medea Muma Pădurii Obayifo Sea witch Sorginak Spearfinger Three Witches Witch of Endor Major historic treatises Formicarius Malleus Maleficarum Summis desiderantes affectibus