Embryonic hemoglobin
Embryonic hemoglobin is a tetramer produced in the blood islands in the embryonic yolk sac during the mesoblastic stage (first week of pregnancy until the end of the pregnancy). The protein is commonly referred to as Hemoglobin ε.
Chromosomal abnormalities can lead to a delay in switching from embryonic hemoglobin.[1]
Types
Hemoglobin Gower 1
Hemoglobin Gower 1 (also referred to as ζ2ε2 or HbE Gower-1) is a form of hemoglobin existing only during embryonic life, and is the primary embryonic hemoglobin. It is composed of two zeta chains and two epsilon chains, and is relatively unstable, breaking down easily.[2]
Hemoglobin Gower 2
Hemoglobin Gower 2 (also referred to as α2ε2 or HbE Gower-2) is a form of hemoglobin existing at low levels during embryonic and fetal life. It is composed of two alpha chains and two epsilon chains, and is somewhat unstable, though not as much as hemoglobin Gower 1.[2] Due to its relative stability compared to hemoglobin Gower 1 and hemoglobin S, it has been proposed as a subject for reactivation in the adult in cases of severe β thalassemia and hemoglobinopathies in subjects for which the reactivation of hemoglobin F is contraindicated due to toxicity concerns.[2]
Hemoglobin Portland I
Hemoglobin Portland I (also referred to as ζ2γ2 or HbE Portland-1) is a form of hemoglobin existing at low levels during embryonic and fetal life, composed of two zeta chains and two gamma chains.[2]
Hemoglobin Portland II
Hemoglobin Portland II (also referred to as ζ2β2 or HbE Portland-2) is a form of hemoglobin existing at low levels during embryonic and fetal life, composed of two zeta chains and two beta chains. It is quite unstable, more so than even hemoglobin Gower 1, and breaks down very rapidly under stress.[2] Despite this, it has been proposed as a candidate for reactivation in cases of severe α thalassemia or hemoglobinopathies afflicting the alpha chain.[2][3]
Table
| ζ chain | α chain | |
| ε chain | HbE Gower 1 | HbE Gower 2 |
| γ chain | HbE Portland I | HbF |
| β chain | HbE Portland II | HbA |
| δ chain | N/A | HbA2 |
References
- ↑ Al-Mufti R, Hambley H, Farzaneh F, Nicolaides KH (July 2000). "Fetal and embryonic hemoglobins in erythroblasts of chromosomally normal and abnormal fetuses at 10-40 weeks of gestation". Haematologica 85 (7): 690–3. PMID 10897119.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 He Z, Russell JE (February 2001). "Expression, purification, and characterization of human hemoglobins Gower-1 (zeta(2)epsilon(2)), Gower-2 (alpha(2)epsilon(2)), and Portland-2 (zeta(2)beta(2)) assembled in complex transgenic-knockout mice". Blood 97 (4): 1099–1105. doi:10.1182/blood.V97.4.1099. PMID 11159543.
- ↑ J. Eric Russell, Stephen A. Leibhaber (November 1998). "Reversal of Lethal α- and β-Thalassemias in Mice by Expression of Human Embryonic Globins". Blood 92 (9): 3057–3063.
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||