Edobacomab
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Mouse |
| Target | endotoxin |
| Clinical data | |
| Intravenous infusion | |
| Identifiers | |
141410-98-2  | |
| None | |
| Chemical data | |
| (what is this?) (verify) | |
Edobacomab, codenamed E5, is a mouse monoclonal antibody that was investigated as a possible treatment for sepsis caused by Gram-negative bacterial infections.
Further reading
- Greenman RL; Schein RM; Martin MA et al. (August 1991). "A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group". JAMA 266 (8): 1097–102. doi:10.1001/jama.266.8.1097. PMID 1865542.
- Bone RC; Balk RA; Fein AM et al. (June 1995). "A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized, controlled trial. The E5 Sepsis Study Group". Crit. Care Med. 23 (6): 994–1006. doi:10.1097/00003246-199506000-00003. PMID 7774238.
- Angus DC; Birmingham MC; Balk RA et al. (April 2000). "E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomized controlled trial. E5 Study Investigators". JAMA 283 (13): 1723–30. doi:10.1001/jama.283.13.1723. PMID 10755499.
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