Econazole

Econazole

Systematic (IUPAC) name
(RS)-1-{2-[(4-Chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a684049
Identifiers
CAS Registry Number	27220-47-9 Y
ATC code	D01AC03 G01AF05
PubChem	CID 3198
IUPHAR ligand	2446
DrugBank	DB01127 Y
ChemSpider	3086 Y
UNII	6Z1Y2V4A7M Y
KEGG	D03936 Y
ChEBI	CHEBI:4754 Y
ChEMBL	CHEMBL808 Y
Chemical data
Formula	C18H15Cl3N2O
Molecular mass	381.683 g/mol
SMILES Clc1ccc(c(Cl)c1)C(OCc2ccc(Cl)cc2)Cn3ccnc3
InChI InChI=1S/C18H15Cl3N2O/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2  Y Key:LEZWWPYKPKIXLL-UHFFFAOYSA-N  Y
Y (what is this?)  (verify)

Econazole (commonly used as the nitrate salt) is an antifungal medication of the imidazole class.^[1] It is used as a cream under the brand names Spectazole (United States), Ecostatin (Canada), Pevaryl (Western Europe), and Pevisone (the latter consisting of the combination econazole/triamcinolone) to treat skin infections such as athlete's foot, tinea, pityriasis versicolor, ringworm, and jock itch. It is also sold in Canada under the brand name Ecostatin as vaginal ovules to treat vaginal thrush. In Asia, it is sold under the brand name Endix-G (by Dongkwang, Korea), while in Thailand, it is sold as Ecosone by Qualimed. In Taiwan, it is sold as Vivicome Cream, manufactured by Yong Chang Pharmaceuticals. In Egypt, it is sold as a foam spray by ATM. In Bangladesh, it is sold under the brand name Ecoderm by Rephco Pharmaceuticals Ltd. The combination of econazole nitrate with triamcinolone acetonide is also available under the brand name Ecoderm-TA.^[2]

Adverse effects

About 3% of patients treated with econazole nitrate cream reported side effects. The most common symptoms were burning, itching, erythema, and one outbreak of a pruritic rash.^[3]

References

External links

• Description and details at Drugs.com