EYA2

EYA transcriptional coactivator and phosphatase 2

Rendering based on PDB 3GEB.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsEYA2 ; EAB1
External IDsOMIM: 601654 MGI: 109341 HomoloGene: 40711 ChEMBL: 1293275 GeneCards: EYA2 Gene
EC number3.1.3.48
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez213914049
EnsemblENSG00000064655ENSMUSG00000017897
UniProtO00167O08575
RefSeq (mRNA)NM_005244NM_001271962
RefSeq (protein)NP_005235NP_001258891
Location (UCSC)Chr 20:
45.52 – 45.82 Mb		Chr 2:
165.6 – 165.77 Mb
PubMed search

Eyes absent homolog 2 is a protein that in humans is encoded by the EYA2 gene.[1][2]

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Five transcript variants encoding three distinct isoforms have been identified for this gene.[2]

Interactions

EYA2 has been shown to interact with GNAI2[3] and GNAZ.[3]

References

  1. ↑ Abdelhak S, Kalatzis V, Heilig R, Compain S, Samson D, Vincent C, Weil D, Cruaud C, Sahly I, Leibovici M, Bitner-Glindzicz M, Francis M, Lacombe D, Vigneron J, Charachon R, Boven K, Bedbeder P, Van Regemorter N, Weissenbach J, Petit C (March 1997). "A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family". Nat Genet 15 (2): 157–64. doi:10.1038/ng0297-157. PMID 9020840.
  2. ↑ 2.0 2.1 "Entrez Gene: EYA2 eyes absent homolog 2 (Drosophila)".
  3. ↑ 3.0 3.1 Fan, X; Brass L F; Poncz M; Spitz F; Maire P; Manning D R (October 2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". J. Biol. Chem. (UNITED STATES) 275 (41): 32129–34. doi:10.1074/jbc.M004577200. ISSN 0021-9258. PMID 10906137.

Further reading

  • Andersson B, Wentland MA, Ricafrente JY et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Zimmerman JE, Bui QT, Steingrímsson E et al. (1997). "Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene.". Genome Res. 7 (2): 128–41. doi:10.1101/gr.7.2.128. PMID 9049631.
  • Yu W, Andersson B, Worley KC et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Duncan MK, Kos L, Jenkins NA et al. (1997). "Eyes absent: a gene family found in several metazoan phyla.". Mamm. Genome 8 (7): 479–85. doi:10.1007/s003359900480. PMID 9195991.
  • Borsani G, DeGrandi A, Ballabio A et al. (1999). "EYA4, a novel vertebrate gene related to Drosophila eyes absent.". Hum. Mol. Genet. 8 (1): 11–23. doi:10.1093/hmg/8.1.11. PMID 9887327.
  • Fan X, Brass LF, Poncz M et al. (2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins.". J. Biol. Chem. 275 (41): 32129–34. doi:10.1074/jbc.M004577200. PMID 10906137.
  • Deloukas P, Matthews LH, Ashurst J et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
  • Fee BE, Doyle CA, Cleveland JL (2002). "A novel Eyes Absent 2 protein is expressed in the human eye.". Gene 285 (1–2): 221–8. doi:10.1016/S0378-1119(02)00404-3. PMID 12039049.
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Fougerousse F, Durand M, Lopez S et al. (2003). "Six and Eya expression during human somitogenesis and MyoD gene family activation". J. Muscle Res. Cell. Motil. 23 (3): 255–64. doi:10.1023/A:1020990825644. PMID 12500905.
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Zhang L, Yang N, Huang J et al. (2005). "Transcriptional coactivator Drosophila eyes absent homologue 2 is up-regulated in epithelial ovarian cancer and promotes tumor growth". Cancer Res. 65 (3): 925–32. PMID 15705892.
  • Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.