ESX1

ESX homeobox 1

Identifiers

ESX1 ; ESX1L; ESXR1

External IDs

OMIM: 300154 MGI: 1096388 HomoloGene: 49152 GeneCards: ESX1 Gene

Gene ontology
Molecular function	• RNA polymerase II regulatory region sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription • sequence-specific DNA binding
Cellular component	• nucleus • cytoplasm
Biological process	• negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • negative regulation of transcription, DNA-templated • regulation of cell cycle • labyrinthine layer morphogenesis • labyrinthine layer blood vessel development
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000123576

ENSMUSG00000023443

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr HG1441_PATCH:
103.5 – 103.51 Mb

Chr X:
137.12 – 137.12 Mb

PubMed search

Homeobox protein ESX1 is a protein that in humans is encoded by the ESX1 gene.^[1]^[2]^[3]

References

↑ Fohn LE, Behringer RR (May 2001). "ESX1L, a novel X chromosome-linked human homeobox gene expressed in the placenta and testis". Genomics 74 (1): 105–8. doi:10.1006/geno.2001.6532. PMID 11374906.
↑ Loschiavo M, Nguyen QK, Duselis AR, Vrana PB (Feb 2007). "Mapping and identification of candidate loci responsible for Peromyscus hybrid overgrowth". Mamm Genome 18 (1): 75–85. doi:10.1007/s00335-006-0083-x. PMC 1794137. PMID 17242862.
↑ "Entrez Gene: ESX1 extraembryonic, spermatogenesis, homeobox 1 homolog (mouse)".

Further reading

Murthi P, Doherty VL, Said JM et al. (2006). "Homeobox gene ESX1L expression is decreased in human pre-term idiopathic fetal growth restriction.". Mol. Hum. Reprod. 12 (5): 335–40. doi:10.1093/molehr/gal037. PMID 16613891.
Figueiredo AL, Salles MG, Albano RM, Porto LC (2005). "Molecular and morphologic analyses of expression of ESX1L in different stages of human placental development.". J. Cell. Mol. Med. 8 (4): 545–50. doi:10.1111/j.1582-4934.2004.tb00479.x. PMID 15601583.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ozawa H, Ashizawa S, Naito M et al. (2004). "Paired-like homeodomain protein ESXR1 possesses a cleavable C-terminal region that inhibits cyclin degradation.". Oncogene 23 (39): 6590–602. doi:10.1038/sj.onc.1207884. PMID 15235584.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.