ERVK6

Endogenous retrovirus group K, member 6

Identifiers

ERVK-6 ; ERVK6; HERV-K(C7); HERV-K108; K-Rev; c-orf; cORF

External IDs

Gene ontology
Molecular function	• nucleic acid binding • DNA binding • RNA binding • DNA-directed DNA polymerase activity • RNA-directed DNA polymerase activity • aspartic-type endopeptidase activity • ribonuclease H activity • structural molecule activity • zinc ion binding
Cellular component	• nucleolus • cytoplasm • plasma membrane • integral to membrane • viral capsid • viral envelope
Biological process	• RNA-dependent DNA replication • DNA recombination • proteolysis • DNA integration • viral reproduction • dUTP metabolic process • mRNA transport
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

n/a

n/a

n/a

RefSeq (mRNA)

NM_001007236

n/a

RefSeq (protein)

NP_001007237

n/a

Location (UCSC)

n/a

PubMed search

n/a

HERV-K_19q12 provirus ancestral Pol protein is a protein that in humans is encoded by the ERVK6 gene.^[1]^[2]^[3]

References

↑ Mayer J, Sauter M, Racz A, Scherer D, Mueller-Lantzsch N, Meese E (Mar 1999). "An almost-intact human endogenous retrovirus K on human chromosome 7". Nat Genet 21 (3): 257–8. doi:10.1038/6766. PMID 10080172.
↑ Reus K, Mayer J, Sauter M, Scherer D, Muller-Lantzsch N, Meese E (Jun 2001). "Genomic organization of the human endogenous retrovirus HERV-K(HML-2.HOM) (ERVK6) on chromosome 7". Genomics 72 (3): 314–20. doi:10.1006/geno.2000.6488. PMID 11401447.
↑ "Entrez Gene: ERVK6 endogenous retroviral sequence K, 6".

Löwer R, Tönjes RR, Korbmacher C et al. (1995). "Identification of a Rev-related protein by analysis of spliced transcripts of the human endogenous retroviruses HTDV/HERV-K.". J. Virol. 69 (1): 141–9. PMC 188557. PMID 7983704.
Sauter M, Schommer S, Kremmer E et al. (1995). "Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.". J. Virol. 69 (1): 414–21. PMC 188589. PMID 7983737.
Zsíros J, Jebbink MF, Lukashov VV et al. (1998). "Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.". J. Gen. Virol. 79. ( Pt 1): 61–70. PMID 9460924.
Andersson ML, Lindeskog M, Medstrand P et al. (1999). "Diversity of human endogenous retrovirus class II-like sequences.". J. Gen. Virol. 80. ( Pt 1): 255–60. PMID 9934709.
Berkhout B, Jebbink M, Zsíros J (1999). "Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.". J. Virol. 73 (3): 2365–75. PMC 104482. PMID 9971820.
Barbulescu M, Turner G, Seaman MI et al. (1999). "Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.". Curr. Biol. 9 (16): 861–8. doi:10.1016/S0960-9822(99)80390-X. PMID 10469592.
Tönjes RR, Czauderna F, Kurth R (1999). "Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.". J. Virol. 73 (11): 9187–95. PMC 112952. PMID 10516026.
Sugimoto J, Matsuura N, Kinjo Y et al. (2001). "Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.". Genomics 72 (2): 137–44. doi:10.1006/geno.2001.6473. PMID 11401426.
Wang-Johanning F, Frost AR, Jian B et al. (2003). "Quantitation of HERV-K env gene expression and splicing in human breast cancer.". Oncogene 22 (10): 1528–35. doi:10.1038/sj.onc.1206241. PMID 12629516.
Hillier LW, Fulton RS, Fulton LA et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
de Parseval N, Lazar V, Casella JF et al. (2003). "Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.". J. Virol. 77 (19): 10414–22. doi:10.1128/JVI.77.19.10414-10422.2003. PMC 228468. PMID 12970426.
Blaise S, de Parseval N, Bénit L, Heidmann T (2004). "Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.". Proc. Natl. Acad. Sci. U.S.A. 100 (22): 13013–8. doi:10.1073/pnas.2132646100. PMC 240736. PMID 14557543.
Grimwood J, Gordon LA, Olsen A et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Schmutz J, Martin J, Terry A et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5.". Nature 431 (7006): 268–74. doi:10.1038/nature02919. PMID 15372022.
Galli UM, Sauter M, Lecher B et al. (2005). "Human endogenous retrovirus rec interferes with germ cell development in mice and may cause carcinoma in situ, the predecessor lesion of germ cell tumors.". Oncogene 24 (19): 3223–8. doi:10.1038/sj.onc.1208543. PMID 15735668.
Mayer J, Stuhr T, Reus K et al. (2006). "Haplotype analysis of the human endogenous retrovirus locus HERV-K(HML-2.HOM) and its evolutionary implications.". J. Mol. Evol. 61 (5): 706–15. doi:10.1007/s00239-005-0066-7. PMID 16211423.
Romano CM, Ramalho RF, Zanotto PM (2006). "Tempo and mode of ERV-K evolution in human and chimpanzee genomes.". Arch. Virol. 151 (11): 2215–28. doi:10.1007/s00705-006-0792-1. PMID 16830071.

ERVK6

References

Further reading