EP1 receptor

Prostaglandin E receptor 1 (subtype EP1), 42kDa

Identifiers

External IDs

OMIM: 176802 MGI: 97793 HomoloGene: 738 IUPHAR: 340 ChEMBL: 1811 GeneCards: PTGER1 Gene

Gene ontology
Molecular function	• prostaglandin E receptor activity
Cellular component	• plasma membrane • integral component of plasma membrane
Biological process	• G-protein coupled receptor signaling pathway • response to lipopolysaccharide
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
14.58 – 14.59 Mb

Chr 8:
83.67 – 83.67 Mb

PubMed search

Prostaglandin E receptor 1 (subtype EP₁) is a 42kDa prostaglandin receptor. PTGER1 is its human gene.^[1]

The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G_q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin.^[1]

References

↑ 1.0 1.1 "Entrez Gene: PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa".

External links

"Prostanoid Receptors: EP₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Coleman RA, Smith WL, Narumiya S (1994). "International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.". Pharmacol. Rev. 46 (2): 205–29. PMID 7938166.
Lee TY, Watanabe Y (1975). "A nonlinear regression model as applied to the comparison of axis-angles of electrocardiographic systems.". Japanese heart journal 16 (3): 243–56. doi:10.1536/ihj.16.243. PMID 1160156.
Duncan AM, Anderson LL, Funk CD et al. (1995). "Chromosomal localization of the human prostanoid receptor gene family.". Genomics 25 (3): 740–2. doi:10.1016/0888-7543(95)80022-E. PMID 7759114.
Funk CD, Furci L, FitzGerald GA et al. (1994). "Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype.". J. Biol. Chem. 268 (35): 26767–72. PMID 8253813.
Kurihara Y, Endo H, Kondo H (2001). "Induction of IL-6 via the EP3 subtype of prostaglandin E receptor in rat adjuvant-arthritic synovial cells.". Inflamm. Res. 50 (1): 1–5. doi:10.1007/s000110050716. PMID 11235015.
Kyveris A, Maruscak E, Senchyna M (2002). "Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR.". Mol. Vis. 8: 51–8. PMID 11951086.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Matsuoka Y, Furuyashiki T, Bito H et al. (2003). "Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes.". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4132–7. doi:10.1073/pnas.0633341100. PMC 153060. PMID 12642666.
Richards JA, Brueggemeier RW (2003). "Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes.". J. Clin. Endocrinol. Metab. 88 (6): 2810–6. doi:10.1210/jc.2002-021475. PMID 12788892.
Kitamura T, Itoh M, Noda T et al. (2004). "Combined effects of prostaglandin E receptor subtype EP1 and subtype EP4 antagonists on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice.". Cancer Sci. 94 (7): 618–21. doi:10.1111/j.1349-7006.2003.tb01492.x. PMID 12841871.
Moreland RB, Kim N, Nehra A et al. (2004). "Functional prostaglandin E (EP) receptors in human penile corpus cavernosum.". Int. J. Impot. Res. 15 (5): 362–8. doi:10.1038/sj.ijir.3901042. PMID 14562138.
Su JL, Shih JY, Yen ML et al. (2004). "Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma.". Cancer Res. 64 (2): 554–64. doi:10.1158/0008-5472.CAN-03-1301. PMID 14744769.
Wu T, Wu H, Wang J, Wang J. (2011). "Expression and cellular localization of cyclooxygenases and prostaglandin E synthases in the hemorrhagic brain.". J Neuroinflammation. 8: 22. doi:10.1186/1742-2094-8-22. PMC 3062590. PMID 21385433.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Han C, Wu T (2005). "Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt.". J. Biol. Chem. 280 (25): 24053–63. doi:10.1074/jbc.M500562200. PMID 15855163.
Nicola C, Timoshenko AV, Dixon SJ et al. (2005). "EP1 receptor-mediated migration of the first trimester human extravillous trophoblast: the role of intracellular calcium and calpain.". J. Clin. Endocrinol. Metab. 90 (8): 4736–46. doi:10.1210/jc.2005-0413. PMID 15886234.
Han C, Michalopoulos GK, Wu T (2006). "Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells.". J. Cell. Physiol. 207 (1): 261–70. doi:10.1002/jcp.20560. PMID 16331686.
Durrenberger PF, Facer P, Casula MA et al. (2006). "Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study.". BMC neurology 6: 1. doi:10.1186/1471-2377-6-1. PMC 1361784. PMID 16393343.
Zhao X, Wu T, Chang CF et al. (2015). "Toxic role of prostaglandin E2 receptor EP1 after intracerebral hemorrhage in mice.". Brain Behav Immun. 46: 293–310. doi:10.1016/j.bbi.2015.02.011. PMID 25697396.

McGraw DW, Mihlbachler KA, Schwarb MR et al. (2006). "Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex.". J. Clin. Invest. 116 (5): 1400–9. doi:10.1172/JCI25840. PMC 1451203. PMID 16670773.
Horita H, Kuroda E, Hachisuga T et al. (2007). "Induction of prostaglandin E2 production by leukemia inhibitory factor promotes migration of first trimester extravillous trophoblast cell line, HTR-8/SVneo.". Hum. Reprod. 22 (7): 1801–9. doi:10.1093/humrep/dem125. PMID 17525067.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3

Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)

Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)

Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine (D1 D2 D3 D4 D5) Histamine (H1 H2 H3 H4) Melatonin (1A 1B 1C) TAAR (1 2 3 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 (1 2) FPRL1 OXE Prostaglandin (DP (1 2), EP (1 2 3 4), FP) Prostacyclin Thromboxane

Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Lactate Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Niacin (1 2) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide	B/W (1 2) FF (1 2) S Y (1 2 4 5) Neuromedin (B U (1 2)) Neurotensin (1 2)

Other	Anaphylatoxin (C3a C5a) Angiotensin (1 2) Apelin Bombesin (BRS3 GRPR NMBR) Bradykinin (B1 B2) Chemokine Cholecystokinin (A B) Endothelin (A B) Formyl peptide (1 2 3) FSH Galanin (1 2 3) GHB receptor Gonadotropin-releasing hormone (1 2) Ghrelin Kisspeptin Luteinizing hormone/choriogonadotropin MAS (1 1L D E F G X1 X2 X3 X4) Melanocortin (1 2 3 4 5) MCHR (1 2) Motilin Opioid (Delta Kappa Mu Nociceptin & Zeta, but not Sigma) Orexin (1 2) Oxytocin Prokineticin (1 2) Prolactin-releasing peptide Relaxin (1 2 3 4) Somatostatin (1 2 3 4 5) Tachykinin (1 2 3) Thyrotropin Thyrotropin-releasing hormone Urotensin-II Vasopressin (1A 1B 2)

Miscellaneous

Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 77 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)

Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin like

Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)

Adhesion	ADGRG (1 2 3 4 5 6 7)

Other	Brain-specific angiogenesis inhibitor (1 2 3) Cadherin (1 2 3) Calcitonin CALCRL CD97 Corticotropin-releasing hormone (1 2) EMR (1 2 3) Glucagon (GR GIPR GLP1R GLP2R) Growth hormone releasing hormone PACAPR1 GPR Latrophilin (1 2 3 ELTD1) Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste	TAS1R (1 2 3) TAS2R (1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60)

Other	Calcium-sensing receptor GABA B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F: Frizzled / Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)

Smoothened	Smoothened

Index of signal transduction

Description	Intercellular neuropeptides growth factors cytokines hormones Cell surface receptors ligand-gated enzyme-linked G protein-coupled immunoglobulin superfamily integrins neuropeptide growth factor cytokine Intracellular adaptor proteins GTP-binding MAP kinase Calcium signaling Lipid signaling Pathways hedgehog Wnt TGF beta MAPK ERK notch JAK-STAT apoptosis hippo TLR

EP1 receptor

See also

References

External links

Further reading