ENAH (gene)
| Enabled homolog (Drosophila) | |||||||||||||
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 PDB rendering of an EVH1 domain. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | ENAH ; ENA; MENA; NDPP1 | ||||||||||||
| External IDs | OMIM: 609061 HomoloGene: 134005 GeneCards: ENAH Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 55740 | 13800 | |||||||||||
| Ensembl | ENSG00000154380 | ENSMUSG00000022995 | |||||||||||
| UniProt | Q8N8S7 | Q03173 | |||||||||||
| RefSeq (mRNA) | NM_001008493 | NM_001083120 | |||||||||||
| RefSeq (protein) | NP_001008493 | NP_001076589 | |||||||||||
| Location (UCSC) | Chr 1: 225.67 – 225.84 Mb | Chr 1: 181.9 – 182.02 Mb | |||||||||||
| PubMed search | |||||||||||||
Protein enabled homolog is a protein that in humans is encoded by the ENAH gene.[1][2]
Interactions
ENAH (gene) has been shown to interact with ABI1[3] and ZYX.[3][4]
References
- ↑ Sazuka T, Tomooka Y, Kathju S, Ikawa Y, Noda M, Kumar S (December 1992). "Identification of a developmentally regulated gene in the mouse central nervous system which encodes a novel proline rich protein". Biochim Biophys Acta 1132 (3): 240–8. doi:10.1016/0167-4781(92)90156-t. PMID 1420303.
- ↑ "Entrez Gene: ENAH enabled homolog (Drosophila)".
- ↑ 3.0 3.1 Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, Shishido T (2003). "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase". J. Biol. Chem. 278 (24): 21685–92. doi:10.1074/jbc.M301447200. PMID 12672821.
- ↑ Drees B, Friederich E, Fradelizi J, Louvard D, Beckerle MC, Golsteyn RM (2000). "Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins". J. Biol. Chem. 275 (29): 22503–11. doi:10.1074/jbc.M001698200. PMID 10801818.
Further reading
- Niebuhr K, Ebel F, Frank R et al. (1997). "A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family.". Embo J. 16 (17): 5433–44. doi:10.1093/emboj/16.17.5433. PMC 1170174. PMID 9312002.
- Ermekova KS, Zambrano N, Linn H et al. (1998). "The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled.". J. Biol. Chem. 272 (52): 32869–77. doi:10.1074/jbc.272.52.32869. PMID 9407065.
- Mammoto A, Sasaki T, Asakura T et al. (1998). "Interactions of drebrin and gephyrin with profilin.". Biochem. Biophys. Res. Commun. 243 (1): 86–9. doi:10.1006/bbrc.1997.8068. PMID 9473484.
- Geese M, Schlüter K, Rothkegel M et al. (2000). "Accumulation of profilin II at the surface of Listeria is concomitant with the onset of motility and correlates with bacterial speed.". J. Cell. Sci. 113 (8): 1415–26. PMID 10725224.
- Krause M, Sechi AS, Konradt M et al. (2000). "Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton.". J. Cell Biol. 149 (1): 181–94. doi:10.1083/jcb.149.1.181. PMC 2175102. PMID 10747096.
- Drees B, Friederich E, Fradelizi J et al. (2000). "Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins.". J. Biol. Chem. 275 (29): 22503–11. doi:10.1074/jbc.M001698200. PMID 10801818.
- Krugmann S, Jordens I, Gevaert K et al. (2002). "Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex.". Curr. Biol. 11 (21): 1645–55. doi:10.1016/S0960-9822(01)00506-1. PMID 11696321.
- Coutts AS, MacKenzie E, Griffith E, Black DM (2003). "TES is a novel focal adhesion protein with a role in cell spreading.". J. Cell. Sci. 116 (Pt 5): 897–906. doi:10.1242/jcs.00278. PMID 12571287.
- Tani K, Sato S, Sukezane T et al. (2003). "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase.". J. Biol. Chem. 278 (24): 21685–92. doi:10.1074/jbc.M301447200. PMID 12672821.
- Garvalov BK, Higgins TE, Sutherland JD et al. (2003). "The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions.". J. Cell Biol. 161 (1): 33–9. doi:10.1083/jcb.200211015. PMC 2172870. PMID 12695497.
- Park KW, Morrison CM, Sorensen LK et al. (2003). "Robo4 is a vascular-specific receptor that inhibits endothelial migration.". Dev. Biol. 261 (1): 251–67. doi:10.1016/S0012-1606(03)00258-6. PMID 12941633.
- Giesemann T, Schwarz G, Nawrotzki R et al. (2003). "Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and Mena: a possible link to the microfilament system.". J. Neurosci. 23 (23): 8330–9. PMID 12967995.
- Salazar MA, Kwiatkowski AV, Pellegrini L et al. (2004). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton.". J. Biol. Chem. 278 (49): 49031–43. doi:10.1074/jbc.M308104200. PMID 14506234.
- Stüven T, Hartmann E, Görlich D (2003). "Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes.". Embo J. 22 (21): 5928–40. doi:10.1093/emboj/cdg565. PMC 275422. PMID 14592989.
- Di Modugno F, Bronzi G, Scanlan MJ et al. (2004). "Human Mena protein, a serex-defined antigen overexpressed in breast cancer eliciting both humoral and CD8+ T-cell immune response.". Int. J. Cancer 109 (6): 909–18. doi:10.1002/ijc.20094. PMID 15027125.
- Tanoue T, Takeichi M (2004). "Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact.". J. Cell Biol. 165 (4): 517–28. doi:10.1083/jcb.200403006. PMC 2172355. PMID 15148305.
- Krause M, Leslie JD, Stewart M et al. (2004). "Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics.". Dev. Cell 7 (4): 571–83. doi:10.1016/j.devcel.2004.07.024. PMID 15469845.
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