EMILIN1

Elastin microfibril interfacer 1

Rendering based on PDB 2KA3.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2KA3, 2OII

Identifiers

EMILIN1 ; EMI; EMILIN; gp115

External IDs

OMIM: 130660 MGI: 1926189 HomoloGene: 5117 GeneCards: EMILIN1 Gene

Gene ontology
Molecular function	• protein binding • extracellular matrix constituent conferring elasticity • identical protein binding
Cellular component	• extracellular region • proteinaceous extracellular matrix • collagen trimer • extracellular matrix • extracellular vesicular exosome
Biological process	• cell adhesion • positive regulation of cell-substrate adhesion • extracellular matrix organization
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000138080

ENSMUSG00000029163

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
27.3 – 27.31 Mb

Chr 5:
30.91 – 30.92 Mb

PubMed search

EMILIN-1 is a protein that in humans is encoded by the EMILIN1 gene.^[1]

References

↑ "Entrez Gene: EMILIN1 elastin microfibril interfacer 1".

Further reading

Doliana R; Mongiat M; Bucciotti F et al. (1999). "EMILIN, a component of the elastic fiber and a new member of the C1q/tumor necrosis factor superfamily of proteins". J. Biol. Chem. 274 (24): 16773–81. doi:10.1074/jbc.274.24.16773. PMID 10358019.
Doliana R; Canton A; Bucciotti F et al. (2000). "Structure, chromosomal localization, and promoter analysis of the human elastin microfibril interfase located proteIN (EMILIN) gene". J. Biol. Chem. 275 (2): 785–92. doi:10.1074/jbc.275.2.785. PMID 10625608.
Mongiat M; Mungiguerra G; Bot S et al. (2000). "Self-assembly and supramolecular organization of EMILIN". J. Biol. Chem. 275 (33): 25471–80. doi:10.1074/jbc.M001426200. PMID 10821830.
Sterzel RB; Hartner A; Schlötzer-Schrehardt U et al. (2000). "Elastic fiber proteins in the glomerular mesangium in vivo and in cell culture". Kidney Int. 58 (4): 1588–602. doi:10.1046/j.1523-1755.2000.00320.x. PMID 11012893.
Doliana R; Bot S; Mungiguerra G et al. (2001). "Isolation and characterization of EMILIN-2, a new component of the growing EMILINs family and a member of the EMI domain-containing superfamily". J. Biol. Chem. 276 (15): 12003–11. doi:10.1074/jbc.M011591200. PMID 11278945.
Spessotto P; Cervi M; Mucignat MT et al. (2003). "beta 1 Integrin-dependent cell adhesion to EMILIN-1 is mediated by the gC1q domain". J. Biol. Chem. 278 (8): 6160–7. doi:10.1074/jbc.M208322200. PMID 12456677.
Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Verdone G; Colebrooke SA; Boyd J et al. (2004). "Sequence-specific backbone NMR assignments for the C-terminal globular domain of EMILIN-1". J. Biomol. NMR 29 (1): 91–2. doi:10.1023/B:JNMR.0000019460.94913.6a. PMID 15017143.
Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wang L; Zhu YF; Guo XJ et al. (2006). "A two-dimensional electrophoresis reference map of human ovary". J. Mol. Med. 83 (10): 812–21. doi:10.1007/s00109-005-0676-y. PMID 16021519.
Rual JF; Venkatesan K; Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Lewandrowski U, Moebius J, Walter U, Sickmann A (2006). "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach". Mol. Cell Proteomics 5 (2): 226–33. doi:10.1074/mcp.M500324-MCP200. PMID 16263699.
Otsuki T; Ota T; Nishikawa T et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.