ELAVL1

ELAV like RNA binding protein 1

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3HI9, 4ED5, 4EGL, 4FXV

Identifiers

Symbols

ELAVL1 ; ELAV1; HUR; Hua; MelG

External IDs

OMIM: 603466 MGI: 1100851 HomoloGene: 20367 ChEMBL: 1250379 GeneCards: ELAVL1 Gene

Gene ontology
Molecular function	• nucleotide binding • RNA binding • double-stranded RNA binding • mRNA binding • mRNA 3'-UTR binding • protein binding • AU-rich element binding • protein kinase binding • mRNA 3'-UTR AU-rich region binding • poly(A) RNA binding
Cellular component	• nucleus • nucleoplasm • cytoplasm • cytosol • membrane
Biological process	• multicellular organismal development • gene expression • RNA metabolic process • mRNA metabolic process • positive regulation of translation • mRNA stabilization • 3'-UTR-mediated mRNA stabilization • regulation of stem cell maintenance
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
8.02 – 8.07 Mb

Chr 8:
4.28 – 4.33 Mb

PubMed search

ELAV-like protein 1 or HuR (human antigen R) is a protein that in humans is encoded by the ELAVL1 gene.^[1]^[2]

The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. It stabilizes mRNAs and thereby regulates gene expression.^[3]

A consensus secondary structure and primary sequence for the targets of the HuR RNA binding protein.^[4]^[5]

References

↑ Ma WJ, Cheng S, Campbell C, Wright A, Furneaux H (Jun 1996). "Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein". J Biol Chem 271 (14): 8144–8151. doi:10.1074/jbc.271.14.8144. PMID 8626503.
↑ Ma WJ, Furneaux H (Feb 1997). "Localization of the human HuR gene to chromosome 19p13.2". Hum Genet 99 (1): 32–33. doi:10.1007/s004390050305. PMID 9003489.
↑ "Entrez Gene: ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)".
↑ López de Silanes, I; Zhan, M; Lal, A; Yang, X; Gorospe, M (Mar 2, 2004). "Identification of a target RNA motif for RNA-binding protein HuR.". Proceedings of the National Academy of Sciences of the United States of America 101 (9): 2987–92. doi:10.1073/pnas.0306453101. PMID 14981256.
↑ Dassi, E; Zuccotti, P; Leo, S; Provenzani, A; Assfalg, M; D'Onofrio, M; Riva, P; Quattrone, A (Mar 1, 2013). "Hyper conserved elements in vertebrate mRNA 3'-UTRs reveal a translational network of RNA-binding proteins controlled by HuR.". Nucleic acids research 41 (5): 3201–16. doi:10.1093/nar/gkt017. PMID 23376935.

Abdelmohsen K, Lal A, Kim HH, Gorospe M (2007). "Posttranscriptional orchestration of an anti-apoptotic program by HuR". Cell Cycle 6 (11): 1288–92. doi:10.4161/cc.6.11.4299. PMID 17534146.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Sakai K, Kitagawa Y, Hirose G (1999). "Analysis of the RNA recognition motifs of human neuronal ELAV-like proteins in binding to a cytokine mRNA". Biochem. Biophys. Res. Commun. 256 (2): 263–268. doi:10.1006/bbrc.1999.0282. PMID 10079173.
Wang W; Furneaux H; Cheng H et al. (2000). "HuR regulates p21 mRNA stabilization by UV light". Mol. Cell. Biol. 20 (3): 760–769. doi:10.1128/MCB.20.3.760-769.2000. PMC 85192. PMID 10629032.
Blaxall BC; Pellett AC; Wu SC et al. (2000). "Purification and characterization of beta-adrenergic receptor mRNA-binding proteins". J. Biol. Chem. 275 (6): 4290–4297. doi:10.1074/jbc.275.6.4290. PMID 10660597.
Park S; Myszka DG; Yu M et al. (2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA". Mol. Cell. Biol. 20 (13): 4765–4772. doi:10.1128/MCB.20.13.4765-4772.2000. PMC 85909. PMID 10848602.
Spångberg K, Wiklund L, Schwartz S (2000). "HuR, a protein implicated in oncogene and growth factor mRNA decay, binds to the 3' ends of hepatitis C virus RNA of both polarities". Virology 274 (2): 378–390. doi:10.1006/viro.2000.0461. PMID 10964780.
Brennan CM, Gallouzi IE, Steitz JA (2000). "Protein ligands to HuR modulate its interaction with target mRNAs in vivo". J. Cell Biol. 151 (1): 1–14. doi:10.1083/jcb.151.1.1. PMC 2189805. PMID 11018049.
Gallouzi IE, Brennan CM, Steitz JA (2001). "Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock". RNA 7 (9): 1348–1361. doi:10.1017/S1355838201016089. PMC 1370177. PMID 11565755. (Retracted. If this is intentional, please replace {{Retracted}} with {{Retracted|intentional=yes}}.)
Gallouzi IE, Steitz JA (2001). "Delineation of mRNA export pathways by the use of cell-permeable peptides". Science 294 (5548): 1895–1901. doi:10.1126/science.1064693. PMID 11729309.
Goldberg-Cohen I, Furneauxb H, Levy AP (2002). "A 40-bp RNA element that mediates stabilization of vascular endothelial growth factor mRNA by HuR". J. Biol. Chem. 277 (16): 13635–13640. doi:10.1074/jbc.M108703200. PMID 11834731.
Wang W; Fan J; Yang X et al. (2002). "AMP-activated kinase regulates cytoplasmic HuR". Mol. Cell. Biol. 22 (10): 3425–3436. doi:10.1128/MCB.22.10.3425-3436.2002. PMC 133799. PMID 11971974.
Yeap BB; Voon DC; Vivian JP et al. (2002). "Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA". J. Biol. Chem. 277 (30): 27183–27192. doi:10.1074/jbc.M202883200. PMID 12011088.
Li H; Park S; Kilburn B et al. (2003). "Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase". J. Biol. Chem. 277 (47): 44623–44630. doi:10.1074/jbc.M206187200. PMID 12237300.
Chen CY, Xu N, Shyu AB (2002). "Highly selective actions of HuR in antagonizing AU-rich element-mediated mRNA destabilization". Mol. Cell. Biol. 22 (20): 7268–7278. doi:10.1128/MCB.22.20.7268-7278.2002. PMC 139819. PMID 12242302.
Giles KM; Daly JM; Beveridge DJ et al. (2003). "The 3'-untranslated region of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including HuR and poly(C)-binding protein". J. Biol. Chem. 278 (5): 2937–2946. doi:10.1074/jbc.M208439200. PMID 12431987.
Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wang W; Yang X; López de Silanes I et al. (2003). "Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function". J. Biol. Chem. 278 (29): 27016–27023. doi:10.1074/jbc.M300318200. PMID 12730239.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

ELAVL1

See also

References

Further reading