EIF4G3

Eukaryotic translation initiation factor 4 gamma, 3

PDB rendering based on 1hu3.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1HU3

Identifiers

Symbols

EIF4G3 ; eIF-4G 3; eIF4G 3; eIF4GII

External IDs

OMIM: 603929 MGI: 1923935 HomoloGene: 2789 GeneCards: EIF4G3 Gene

Gene ontology
Molecular function	• RNA cap binding • translation initiation factor activity • translation factor activity, nucleic acid binding • poly(A) RNA binding
Cellular component	• cytosol • eukaryotic translation initiation factor 4F complex
Biological process	• positive regulation of protein phosphorylation • translational initiation • regulation of translational initiation • spermatogenesis • viral process • cytokine-mediated signaling pathway • positive regulation of translation • positive regulation of meiosis I
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
21.13 – 21.5 Mb

Chr 4:
137.99 – 138.21 Mb

PubMed search

Eukaryotic translation initiation factor 4 gamma 3 is a protein that in humans is encoded by the EIF4G3 gene.^[1]^[2] The gene encodes a protein that functions in translation by aiding the assembly of the ribosome onto the messenger RNA template.^[3] Confusingly, this protein is usually referred to as eIF4GII, as although EIF4G3 is the third gene that is similar to eukaryotic translation initiation factor 4 gamma, the second isoform EIF4G2 is not an active translation initiation factor.^[4]

Interactions

EIF4G3 has been shown to interact with PABPC1.^[5]

References

↑ Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S et al. (Jan 1998). "A novel functional human eukaryotic translation initiation factor 4G". Mol. Cell. Biol. 18 (1): 334–42. PMC 121501. PMID 9418880. CS1 maint: Date and year (link)
↑ "Entrez Gene: EIF4G3 eukaryotic translation initiation factor 4 gamma, 3".
↑ Gingras AC, Raught B, Sonenberg N (1999). "eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation". Annu. Rev. Biochem. 68: 913–63. doi:10.1146/annurev.biochem.68.1.913. PMID 10872469.
↑ Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S et al. (1998). "A novel functional human eukaryotic translation initiation factor 4G". Mol. Cell. Biol. 18 (1): 334–42. PMC 121501. PMID 9418880.
↑ Imataka H, Gradi A, Sonenberg N (Dec 1998). "A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation". EMBO J. 17 (24): 7480–9. doi:10.1093/emboj/17.24.7480. PMC 1171091. PMID 9857202. CS1 maint: Date and year (link)

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Imataka H, Gradi A, Sonenberg N (1998). "A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation". EMBO J. 17 (24): 7480–9. doi:10.1093/emboj/17.24.7480. PMC 1171091. PMID 9857202.
Pyronnet S, Imataka H, Gingras AC, Fukunaga R, Hunter T, Sonenberg N (1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E". EMBO J. 18 (1): 270–9. doi:10.1093/emboj/18.1.270. PMC 1171121. PMID 9878069.
Waskiewicz AJ, Johnson JC, Penn B, Mahalingam M, Kimball SR, Cooper JA (1999). "Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo". Mol. Cell. Biol. 19 (3): 1871–80. PMC 83980. PMID 10022874.
Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Marcotrigiano J, Lomakin IB, Sonenberg N, Pestova TV, Hellen CU, Burley SK (2001). "A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery". Mol. Cell 7 (1): 193–203. doi:10.1016/S1097-2765(01)00167-8. PMID 11172724.
Gradi A, Svitkin YV, Sommergruber W, Imataka H, Morino S, Skern T et al. (2003). "Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different". J. Virol. 77 (8): 5026–9. doi:10.1128/JVI.77.8.5026-5029.2003. PMC 152112. PMID 12663812.
Miura T, Shiratori Y, Shimma N (2003). "Backbone resonance assignment of human eukaryotic translation initiation factor 4E (eIF4E) in complex with 7-methylguanosine diphosphate (m7GDP) and a 17-amino acid peptide derived from human eIF4GII". J. Biomol. NMR 27 (3): 279–80. doi:10.1023/A:1025442322316. PMID 12975586.
Qin H, Raught B, Sonenberg N, Goldstein EG, Edelman AM (2003). "Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I". J. Biol. Chem. 278 (49): 48570–9. doi:10.1074/jbc.M308781200. PMID 14507913.
Gradi A, Foeger N, Strong R, Svitkin YV, Sonenberg N, Skern T et al. (2004). "Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro". J. Virol. 78 (7): 3271–8. doi:10.1128/JVI.78.7.3271-3278.2004. PMC 371048. PMID 15016848.
Lejeune F, Ranganathan AC, Maquat LE (2004). "eIF4G is required for the pioneer round of translation in mammalian cells". Nat. Struct. Mol. Biol. 11 (10): 992–1000. doi:10.1038/nsmb824. PMID 15361857.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. Vancouver style error (help)
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

PDB gallery

1hu3: MIDDLE DOMAIN OF HUMAN EIF4GII

Protein biosynthesis: translation (prokaryotic, eukaryotic)

Ribosomal proteins

Initiation factor

Prokaryotic

Archaeal

aIF1
aIF2
aIF5
aIF6

Eukaryotic

eIF1	EIF1AX AY 1B

eIF2	EIF2S1 EIF2S2 EIF2S3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF-2 kinase

eIF3	EIF3A B C D F G H I J K M S6

eIF4	EIF4A2 A3 B E1 E2 G1 G2 G3 H

eIF5	EIF5A A2 B

eIF6	EIF6

Elongation factor

Prokaryotic	EF-Tu EF-Ts EF-G

Archaeal	aEF-1, aEF-2

Eukaryotic	EEF-1 EEF1A1 EEF1A2 EEF1A3 EEF1B1 EEF1B2 EEF1B3 EEF1B4 EEF1D EEF1E1 EEF1G EEF2

Release factor

Other

Other concepts

Index of genetics

Description	Gene expression DNA replication cycle recombination repair binding proteins Transcription factors regulators nucleic acids RNA RNA binding proteins ribonucleoproteins repeated sequence modification Translation ribosome modification nexins Proteins domains Structure primary secondary tertiary quaternary

Disease	Replication and repair Transcription factor Transcription Translation

EIF4G3

Interactions

References

Further reading