EIF4EBP3
| Eukaryotic translation initiation factor 4E binding protein 3 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | EIF4EBP3 ; 4E-BP3; 4EBP3 | ||||||||||||
| External IDs | OMIM: 603483 MGI: 1270847 HomoloGene: 37841 GeneCards: EIF4EBP3 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8637 | 108112 | |||||||||||
| Ensembl | ENSG00000243056 | ENSMUSG00000090264 | |||||||||||
| UniProt | O60516 | Q80VV3 | |||||||||||
| RefSeq (mRNA) | NM_003732 | NM_201256 | |||||||||||
| RefSeq (protein) | NP_003723 | NP_957708 | |||||||||||
| Location (UCSC) | Chr 5: 139.93 – 139.93 Mb | Chr 18: 36.66 – 36.67 Mb | |||||||||||
| PubMed search | |||||||||||||
Eukaryotic translation initiation factor 4E-binding protein 3 is a protein that in humans is encoded by the EIF4EBP3 gene.[1][2]
Function
This gene encodes a member of the EIF4EBP family which derives it name from proteins that bind to eukaryotic initiation factor 4E and that prevent its assembly into EIF4F. Co-transcription of this gene and the neighboring upstream gene (MASK) generates a transcript (MASK-BP3) which encodes a fusion protein composed of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments.[2]
Interactions
EIF4EBP3 has been shown to interact with EIF4E.[1][3]
References
- ↑ 1.0 1.1 Poulin F, Gingras AC, Olsen H, Chevalier S, Sonenberg N (Jul 1998). "4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family". J. Biol. Chem. 273 (22): 14002–7. doi:10.1074/jbc.273.22.14002. PMID 9593750.
- ↑ 2.0 2.1 "Entrez Gene: EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3".
- ↑ Kleijn M, Scheper GC, Wilson ML, Tee AR, Proud CG (Dec 2002). "Localisation and regulation of the eIF4E-binding protein 4E-BP3". FEBS Lett. 532 (3): 319–23. doi:10.1016/S0014-5793(02)03694-3. PMID 12482586.
Further reading
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Joshi B, Cameron A, Jagus R (2004). "Characterization of mammalian eIF4E-family members". Eur. J. Biochem. 271 (11): 2189–203. doi:10.1111/j.1432-1033.2004.04149.x. PMID 15153109.
- Poulin F, Brueschke A, Sonenberg N (2003). "Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK". J. Biol. Chem. 278 (52): 52290–7. doi:10.1074/jbc.M310761200. PMID 14557257.
- Ferguson G, Mothe-Satney I, Lawrence JC (2003). "Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E". J. Biol. Chem. 278 (48): 47459–65. doi:10.1074/jbc.M307949200. PMID 14507920.
- Kleijn M, Scheper GC, Wilson ML, Tee AR, Proud CG (2002). "Localisation and regulation of the eIF4E-binding protein 4E-BP3". FEBS Lett. 532 (3): 319–23. doi:10.1016/S0014-5793(02)03694-3. PMID 12482586.