EIF4E3

Eukaryotic translation initiation factor 4E family member 3
Identifiers
SymbolsEIF4E3 ; MGC39820; MGC86971
External IDsOMIM: 609896 HomoloGene: 41652 GeneCards: EIF4E3 Gene
Orthologs
SpeciesHumanMouse
Entrez31764966892
EnsemblENSG00000163412ENSMUSG00000093661
UniProtQ8N5X7Q9DBB5
RefSeq (mRNA)NM_001134649NM_025829
RefSeq (protein)NP_001128121NP_080105
Location (UCSC)Chr 3:
71.73 – 71.8 Mb		Chr 6:
99.63 – 99.67 Mb
PubMed search

Eukaryotic translation initiation factor 4E family member 3 is a protein that in humans is encoded by the EIF4E3 gene.[1]

EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome.[1][2]

Model organisms

Model organisms have been used in the study of EIF4E3 function. A conditional knockout mouse line, called Eif4e3tm1a(KOMP)Wtsi[7][8] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[9][10][11]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[5][12] Twenty four tests were carried out on mutant mice but no significant abnormalities were observed.[5]

References

  1. ↑ 1.0 1.1 "Entrez Gene: Eukaryotic translation initiation factor 4E family member 3". Retrieved 2011-09-28.
  2. ↑ Joshi, B.; Cameron, A.; Jagus, R. (2004). "Characterization of mammalian eIF4E-family members". European Journal of Biochemistry 271 (11): 2189–2203. doi:10.1111/j.1432-1033.2004.04149.x. PMID 15153109.
  3. ↑ "Salmonella infection data for Eif4e3". Wellcome Trust Sanger Institute.
  4. ↑ "Citrobacter infection data for Eif4e3". Wellcome Trust Sanger Institute.
  5. ↑ 5.0 5.1 5.2 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
  6. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  7. ↑ "International Knockout Mouse Consortium".
  8. ↑ "Mouse Genome Informatics".
  9. ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  10. ↑ Dolgin E (June 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  11. ↑ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  12. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.