EIF4E2

Eukaryotic translation initiation factor 4E family member 2

PDB rendering based on 2jgb.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2JGB, 2JGC

Identifiers

Symbols

EIF4E2 ; 4E-LP; 4EHP; EIF4EL3; IF4e

External IDs

OMIM: 605895 MGI: 1914440 HomoloGene: 128466 GeneCards: EIF4E2 Gene

Gene ontology
Molecular function	• RNA cap binding • translation initiation factor activity • protein binding • translation factor activity, nucleic acid binding • ubiquitin protein ligase binding • poly(A) RNA binding
Cellular component	• cytosol • mRNA cap binding complex
Biological process	• in utero embryonic development • translational initiation • negative regulation of translation • cytokine-mediated signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
233.41 – 233.45 Mb

Chr 1:
87.21 – 87.24 Mb

PubMed search

Eukaryotic translation initiation factor 4E type 2 is a protein that in humans is encoded by the EIF4E2 gene.^[1]^[2]^[3] It belongs to the eukaryotic translation initiation factor 4E family.

Interactions

EIF4E2 has been shown to interact with ARIH1.^[4]

References

↑ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX et al. (Aug 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160. CS1 maint: Date and year (link)
↑ Rom E, Kim HC, Gingras AC, Marcotrigiano J, Favre D, Olsen H et al. (Jun 1998). "Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein". J. Biol. Chem. 273 (21): 13104–9. doi:10.1074/jbc.273.21.13104. PMID 9582349. CS1 maint: Date and year (link)
↑ "Entrez Gene: EIF4E2 eukaryotic translation initiation factor 4E family member 2".
↑ Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA (Nov 2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP". FEBS Lett. 554 (3): 501–4. doi:10.1016/S0014-5793(03)01235-3. PMID 14623119. CS1 maint: Date and year (link)

Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ et al. (2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA (2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP". FEBS Lett. 554 (3): 501–4. doi:10.1016/S0014-5793(03)01235-3. PMID 14623119.
Tee AR, Tee JA, Blenis J (2004). "Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1". FEBS Lett. 564 (1-2): 58–62. doi:10.1016/S0014-5793(04)00313-8. PMID 15094042.
Joshi B, Cameron A, Jagus R (2004). "Characterization of mammalian eIF4E-family members". Eur. J. Biochem. 271 (11): 2189–203. doi:10.1111/j.1432-1033.2004.04149.x. PMID 15153109.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Okumura F, Zou W, Zhang DE (2007). "ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP". Genes Dev. 21 (3): 255–60. doi:10.1101/gad.1521607. PMC 1785121. PMID 17289916.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Rosettani P, Knapp S, Vismara MG, Rusconi L, Cameron AD (2007). "Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms". J. Mol. Biol. 368 (3): 691–705. doi:10.1016/j.jmb.2007.02.019. PMID 17368478.
Zuberek J, Kubacka D, Jablonowska A, Jemielity J, Stepinski J, Sonenberg N et al. (2007). "Weak binding affinity of human 4EHP for mRNA cap analogs". RNA 13 (5): 691–7. doi:10.1261/rna.453107. PMC 1852817. PMID 17369309.

PDB gallery

2jgb: STRUCTURE OF HUMAN EIF4E HOMOLOGOUS PROTEIN 4EHP WITH M7GTP

2jgc: STRUCTURE OF THE HUMAN EIF4E HOMOLOGOUS PROTEIN, 4EHP WITHOUT LIGAND BOUND

Protein biosynthesis: translation (prokaryotic, eukaryotic)

Ribosomal proteins

Initiation factor

Prokaryotic

Archaeal

aIF1
aIF2
aIF5
aIF6

Eukaryotic

eIF1	EIF1AX AY 1B

eIF2	EIF2S1 EIF2S2 EIF2S3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF-2 kinase

eIF3	EIF3A B C D F G H I J K M S6

eIF4	EIF4A2 A3 B E1 E2 G1 G2 G3 H

eIF5	EIF5A A2 B

eIF6	EIF6

Elongation factor

Prokaryotic	EF-Tu EF-Ts EF-G

Archaeal	aEF-1, aEF-2

Eukaryotic	EEF-1 EEF1A1 EEF1A2 EEF1A3 EEF1B1 EEF1B2 EEF1B3 EEF1B4 EEF1D EEF1E1 EEF1G EEF2

Release factor

Other

Other concepts

Index of genetics

Description	Gene expression DNA replication cycle recombination repair binding proteins Transcription factors regulators nucleic acids RNA RNA binding proteins ribonucleoproteins repeated sequence modification Translation ribosome modification nexins Proteins domains Structure primary secondary tertiary quaternary

Disease	Replication and repair Transcription factor Transcription Translation

EIF4E2

Interactions

References

Further reading