EIF4A2

Eukaryotic translation initiation factor 4A2

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3BOR

Identifiers

Symbols

EIF4A2 ; BM-010; DDX2B; EIF4A; EIF4F; eIF-4A-II; eIF4A-II

External IDs

OMIM: 601102 MGI: 106906 HomoloGene: 1487 GeneCards: EIF4A2 Gene

EC number

3.6.4.13

Gene ontology
Molecular function	• translation initiation factor activity • helicase activity • protein binding • ATP binding • ATP-dependent helicase activity • poly(A) RNA binding
Cellular component	• cytosol • eukaryotic translation initiation factor 4F complex
Biological process	• nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • nuclear-transcribed mRNA poly(A) tail shortening • ATP catabolic process • translation • translational initiation • regulation of translational initiation • gene expression • viral process • RNA metabolic process • mRNA metabolic process • cytokine-mediated signaling pathway • cellular protein metabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
186.5 – 186.51 Mb

Chr 16:
23.11 – 23.11 Mb

PubMed search

Eukaryotic initiation factor 4A-II is a protein that in humans is encoded by the EIF4A2 gene.^[1]^[2]

References

↑ Sudo K, Takahashi E, Nakamura Y (Jan 1996). "Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2". Cytogenet Cell Genet 71 (4): 385–8. doi:10.1159/000134145. PMID 8521730.
↑ "Entrez Gene: EIF4A2 eukaryotic translation initiation factor 4A, isoform 2".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Li W, Belsham GJ, Proud CG (2001). "Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo". J. Biol. Chem. 276 (31): 29111–5. doi:10.1074/jbc.C100284200. PMID 11408474.
Kyono K, Miyashiro M, Taguchi I (2002). "Human eukaryotic initiation factor 4AII associates with hepatitis C virus NS5B protein in vitro". Biochem. Biophys. Res. Commun. 292 (3): 659–66. doi:10.1006/bbrc.2002.6702. PMID 11922617.
Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Sarkar M; Das S; Bandyopadhaya A et al. (2005). "Upregulation of human mitochondrial NADH dehydrogenase subunit 5 in intestinal epithelial cells is modulated by Vibrio cholerae pathogenesis". FEBS Lett. 579 (16): 3449–60. doi:10.1016/j.febslet.2005.05.012. PMID 15946665.
Feng P, Everly DN, Read GS (2005). "mRNA Decay during Herpes Simplex Virus (HSV) Infections: Protein-Protein Interactions Involving the HSV Virion Host Shutoff Protein and Translation Factors eIF4H and eIF4A". J. Virol. 79 (15): 9651–64. doi:10.1128/JVI.79.15.9651-9664.2005. PMC 1181552. PMID 16014927.
Cheyssac C; Dina C; Leprêtre F et al. (2006). "EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French families". Diabetes 55 (4): 1171–6. doi:10.2337/diabetes.55.04.06.db05-1298. PMID 16567544.
Ewing RM; Chu P; Elisma F et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Protein biosynthesis: translation (prokaryotic, eukaryotic)

Ribosomal proteins

Initiation factor

Prokaryotic

Archaeal

aIF1
aIF2
aIF5
aIF6

Eukaryotic

eIF1	EIF1AX AY 1B

eIF2	EIF2S1 EIF2S2 EIF2S3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF-2 kinase

eIF3	EIF3A B C D F G H I J K M S6

eIF4	EIF4A2 A3 B E1 E2 G1 G2 G3 H

eIF5	EIF5A A2 B

eIF6	EIF6

Elongation factor

Prokaryotic	EF-Tu EF-Ts EF-G

Archaeal	aEF-1, aEF-2

Eukaryotic	EEF-1 EEF1A1 EEF1A2 EEF1A3 EEF1B1 EEF1B2 EEF1B3 EEF1B4 EEF1D EEF1E1 EEF1G EEF2

Release factor

Other

Other concepts

Index of genetics

Description	Gene expression DNA replication cycle recombination repair binding proteins Transcription factors regulators nucleic acids RNA RNA binding proteins ribonucleoproteins repeated sequence modification Translation ribosome modification nexins Proteins domains Structure primary secondary tertiary quaternary

Disease	Replication and repair Transcription factor Transcription Translation

EIF4A2

References

Further reading