EIF3K
Eukaryotic translation initiation factor 3 subunit K is a protein that in humans is encoded by the EIF3K gene.[1][2][3]
Function
The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003).[supplied by OMIM][3]
Interactions
EIF3K has been shown to interact with Cyclin D3[4] and EIF3A.[2][5]
References
- ↑ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ et al. (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
- ↑ 2.0 2.1 Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (Oct 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125.
- ↑ 3.0 3.1 "Entrez Gene: EIF3S12 eukaryotic translation initiation factor 3, subunit 12".
- ↑ Shen X, Yang Y, Liu W, Sun M, Jiang J, Zong H et al. (Aug 2004). "Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3". FEBS Lett. 573 (1-3): 139–46. doi:10.1016/j.febslet.2004.07.071. PMID 15327989.
- ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Further reading
- Karki S, Ligon LA, DeSantis J, Tokito M, Holzbaur EL (2002). "PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact". Mol. Biol. Cell 13 (5): 1722–34. doi:10.1091/mbc.02-02-0011. PMC 111139. PMID 12006665.
- Wei Z, Zhang P, Zhou Z, Cheng Z, Wan M, Gong W (2004). "Crystal structure of human eIF3k, the first structure of eIF3 subunits". J. Biol. Chem. 279 (33): 34983–90. doi:10.1074/jbc.M405158200. PMID 15180986.
- Shen X, Yang Y, Liu W, Sun M, Jiang J, Zong H et al. (2004). "Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3". FEBS Lett. 573 (1-3): 139–46. doi:10.1016/j.febslet.2004.07.071. PMID 15327989.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
PDB gallery |
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| | 1rz4: Crystal Structure of Human eIF3k |
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| | Description |
- Gene expression
- DNA
- replication
- cycle
- recombination
- repair
- binding proteins
- Transcription
- factors
- regulators
- nucleic acids
- RNA
- RNA binding proteins
- ribonucleoproteins
- repeated sequence
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- Translation
- ribosome
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| | Disease |
- Replication and repair
- Transcription factor
- Transcription
- Translation
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