EIF3EIP

Eukaryotic translation initiation factor 3, subunit L

Identifiers

EIF3L ; EIF3EIP; EIF3S11; EIF3S6IP; HSPC021; HSPC025; MSTP005

External IDs

MGI: 2386251 HomoloGene: 9380 GeneCards: EIF3L Gene

Gene ontology
Molecular function	• translation initiation factor activity • protein binding • poly(A) RNA binding
Cellular component	• fibrillar center • nucleoplasm • eukaryotic translation initiation factor 3 complex • membrane • eukaryotic 43S preinitiation complex • eukaryotic 48S preinitiation complex
Biological process	• formation of translation preinitiation complex • translational initiation • regulation of translational initiation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000100129

ENSMUSG00000033047

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 22:
38.24 – 38.29 Mb

Chr 15:
79.08 – 79.09 Mb

PubMed search

Eukaryotic translation initiation factor 3 subunit L is a protein that in humans is encoded by the EIF3L gene.^[1]^[2]^[3]

Interactions

EIF3EIP has been shown to interact with EIF3A.^[2]^[4]

References

↑ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ et al. (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152. CS1 maint: Date and year (link)
↑ 2.0 2.1 Morris-Desbois C, Réty S, Ferro M, Garin J, Jalinot P (Dec 2001). "The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3". J. Biol. Chem. 276 (49): 45988–95. doi:10.1074/jbc.M104966200. PMID 11590142. Vancouver style error (help) CS1 maint: Date and year (link)
↑ "Entrez Gene: EIF3S6IP eukaryotic translation initiation factor 3, subunit 6 interacting protein".
↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Seither P, Iben S, Thiry M, Grummt I (2001). "PAF67, a novel protein that is associated with the initiation-competent form of RNA polymerase I". Biol. Chem. 382 (8): 1163–70. doi:10.1515/BC.2001.146. PMID 11592397.
Yuan X, Zhao J, Zentgraf H, Hoffmann-Rohrer U, Grummt I (2002). "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter". EMBO Rep. 3 (11): 1082–7. doi:10.1093/embo-reports/kvf212. PMC 1307603. PMID 12393749.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG et al. (2004). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.