EIF2A
| Eukaryotic translation initiation factor 2A, 65kDa | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | EIF2A ; EIF-2A; MST089; MSTP004; MSTP089 | ||||||||||||
| External IDs | OMIM: 609234 MGI: 1098684 HomoloGene: 5969 GeneCards: EIF2A Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 83939 | 229317 | |||||||||||
| Ensembl | ENSG00000144895 | ENSMUSG00000027810 | |||||||||||
| UniProt | Q9BY44 | Q8BJW6 | |||||||||||
| RefSeq (mRNA) | NM_032025 | NM_001005509 | |||||||||||
| RefSeq (protein) | NP_114414 | NP_001005509 | |||||||||||
| Location (UCSC) | Chr 3: 150.26 – 150.3 Mb | Chr 3: 58.53 – 58.56 Mb | |||||||||||
| PubMed search | |||||||||||||
Eukaryotic translation initiation factor 2A is a protein that in humans is encoded by the EIF2A gene.[1][2][3]
EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002).[supplied by OMIM][3]
See also
References
- ↑ Zoll WL, Horton LE, Komar AA, Hensold JO, Merrick WC (Sep 2002). "Characterization of mammalian eIF2A and identification of the yeast homolog". J Biol Chem 277 (40): 37079–87. doi:10.1074/jbc.M207109200. PMID 12133843.
- ↑ Merrick WC (Aug 1992). "Mechanism and regulation of eukaryotic protein synthesis". Microbiol Rev 56 (2): 291–315. PMC 372869. PMID 1620067.
- ↑ 3.0 3.1 "Entrez Gene: EIF2A eukaryotic translation initiation factor 2A, 38kDa".
Further reading
- Koumenis C, Naczki C, Koritzinsky M et al. (2002). "Regulation of Protein Synthesis by Hypoxia via Activation of the Endoplasmic Reticulum Kinase PERK and Phosphorylation of the Translation Initiation Factor eIF2α". Mol. Cell. Biol. 22 (21): 7405–16. doi:10.1128/MCB.22.21.7405-7416.2002. PMC 135664. PMID 12370288.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Page AB, Owen CR, Kumar R et al. (2003). "Persistent eIF2alpha(P) is colocalized with cytoplasmic cytochrome c in vulnerable hippocampal neurons after 4 hours of reperfusion following 10-minute complete brain ischemia". Acta Neuropathol. 106 (1): 8–16. doi:10.1007/s00401-003-0693-2. PMID 12687390.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Ito T, Marintchev A, Wagner G (2005). "Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B". Structure 12 (9): 1693–704. doi:10.1016/j.str.2004.07.010. PMID 15341733.
- Weiser DC, Sikes S, Li S, Shenolikar S (2005). "The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms". J. Biol. Chem. 279 (47): 48904–14. doi:10.1074/jbc.M404416200. PMID 15345721.
- Komar AA, Gross SR, Barth-Baus D et al. (2005). "Novel characteristics of the biological properties of the yeast Saccharomyces cerevisiae eukaryotic initiation factor 2A". J. Biol. Chem. 280 (16): 15601–11. doi:10.1074/jbc.M413728200. PMID 15718232.
- Wang J, Laschinger C, Zhao XH et al. (2005). "Mechanical force activates eIF-2alpha phospho-kinases in fibroblast". Biochem. Biophys. Res. Commun. 330 (1): 123–30. doi:10.1016/j.bbrc.2005.02.140. PMID 15781241.
- Gorrini C, Loreni F, Gandin V et al. (2005). "Fibronectin controls cap-dependent translation through β1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways". Proc. Natl. Acad. Sci. U.S.A. 102 (26): 9200–5. doi:10.1073/pnas.0409513102. PMC 1166589. PMID 15961545.
- Su Q, Wang S, Baltzis D et al. (2006). "Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2α RNA-dependent protein kinase". Proc. Natl. Acad. Sci. U.S.A. 103 (1): 63–8. doi:10.1073/pnas.0508207103. PMC 1324992. PMID 16373505.
- Squatrito M, Mancino M, Sala L, Draetta GF (2006). "Ebp1 is a dsRNA-binding protein associated with ribosomes that modulates eIF2alpha phosphorylation". Biochem. Biophys. Res. Commun. 344 (3): 859–68. doi:10.1016/j.bbrc.2006.03.205. PMID 16631606.
- Scheuner D, Patel R, Wang F et al. (2006). "Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis". J. Biol. Chem. 281 (30): 21458–68. doi:10.1074/jbc.M603784200. PMID 16717090.
- Mazroui R, Sukarieh R, Bordeleau ME et al. (2007). "Inhibition of Ribosome Recruitment Induces Stress Granule Formation Independently of Eukaryotic Initiation Factor 2α Phosphorylation". Mol. Biol. Cell 17 (10): 4212–9. doi:10.1091/mbc.E06-04-0318. PMC 1635342. PMID 16870703.
- Fribley AM, Evenchik B, Zeng Q et al. (2006). "Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa". J. Biol. Chem. 281 (42): 31440–7. doi:10.1074/jbc.M604356200. PMID 16928686.
- Fritsch RM, Schneider G, Saur D et al. (2007). "Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation". J. Biol. Chem. 282 (31): 22551–62. doi:10.1074/jbc.M702673200. PMID 17553788.
- Nayak R, Pintel DJ (2007). "Adeno-Associated Viruses Can Induce Phosphorylation of eIF2α via PKR Activation, Which Can Be Overcome by Helper Adenovirus Type 5 Virus-Associated RNA". J. Virol. 81 (21): 11908–16. doi:10.1128/JVI.01132-07. PMC 2168773. PMID 17715234.