EIF1AY
| Eukaryotic translation initiation factor 1A, Y-linked | |||||||||||||
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 PDB rendering based on 1d7q. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | EIF1AY ; eIF-4C | ||||||||||||
| External IDs | OMIM: 400014 MGI: 95298 HomoloGene: 100715 GeneCards: EIF1AY Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9086 | 66235 | |||||||||||
| Ensembl | ENSG00000198692 | ENSMUSG00000067194 | |||||||||||
| UniProt | O14602 | Q8BMJ3 | |||||||||||
| RefSeq (mRNA) | NM_001278612 | NM_025437 | |||||||||||
| RefSeq (protein) | NP_001265541 | NP_079713 | |||||||||||
| Location (UCSC) | Chr Y: 22.74 – 22.76 Mb | Chr X: 159.37 – 159.39 Mb | |||||||||||
| PubMed search | |||||||||||||
Eukaryotic translation initiation factor 1A, Y-chromosomal is a protein that in humans is encoded by the EIF1AY gene.[1][2]
This gene encodes a protein similar to eukaryotic translation initiation factor 1A (EIF1A). EIF1A is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA.[2]
References
- ↑ Lahn BT, Page DC (Nov 1997). "Functional coherence of the human Y chromosome". Science 278 (5338): 675–80. doi:10.1126/science.278.5338.675. PMID 9381176.
- ↑ 2.0 2.1 "Entrez Gene: EIF1AY eukaryotic translation initiation factor 1A, Y-linked".
Further reading
- Lim J; Hao T; Shaw C et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Fortna A; Kim Y; MacLaren E et al. (2006). "Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution". PLoS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMC 449870. PMID 15252450.
- Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Mol. Biol. Evol. 21 (2): 384–96. doi:10.1093/molbev/msh027. PMID 14660691.
- Skaletsky H; Kuroda-Kawaguchi T; Minx PJ et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature 423 (6942): 825–37. doi:10.1038/nature01722. PMID 12815422.
- Marintchev A, Kolupaeva VG, Pestova TV, Wagner G (2003). "Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: A new interaction between old partners". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1535–40. doi:10.1073/pnas.0437845100. PMC 149867. PMID 12569173.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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