ECGF1
Thymidine phosphorylase is an enzyme that in humans is encoded by the TYMP gene.[1][2]
Platelet-derived endothelial cell growth factor (ECGF1) is an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. ECGF1 has a highly restricted target cell specificity acting only on endothelial cells.
Because it limits glial cell proliferation, ECGF1 is also known as thymidine phosphorylase and as gliostatin. The ECGF1 gene contains 10 exons spanning more than 4.3 kb. Thymidine phosphorylase activity of ECGF1 in leukocytes from mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) patients was less than 5 percent of controls, indicating that loss-of-function mutations in thymidine phosphorylase cause MNGIE.[3]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
Fluorouracil (5-FU) Activity edit
- ↑ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".
References
- ↑ Usuki K, Saras J, Waltenberger J, Miyazono K, Pierce G, Thomason A, Heldin CH (Jun 1992). "Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity". Biochem Biophys Res Commun 184 (3): 1311–6. doi:10.1016/S0006-291X(05)80025-7. PMID 1590793.
- ↑ Spinazzola A, Marti R, Nishino I, Andreu AL, Naini A, Tadesse S, Pela I, Zammarchi E, Donati MA, Oliver JA, Hirano M (Feb 2002). "Altered thymidine metabolism due to defects of thymidine phosphorylase". J Biol Chem 277 (6): 4128–33. doi:10.1074/jbc.M111028200. PMID 11733540.
- ↑ "Entrez Gene: ECGF1 endothelial cell growth factor 1 (platelet-derived)".
External links
Further reading
- Yang Q, Yoshimura G, Mori I et al. (2002). "Thymidine phosphorylase and breast carcinoma.". Anticancer Res. 22 (4): 2355–60. PMID 12174926.
- Asai K, Nakanishi K, Isobe I et al. (1992). "Neurotrophic action of gliostatin on cortical neurons. Identity of gliostatin and platelet-derived endothelial cell growth factor.". J. Biol. Chem. 267 (28): 20311–6. PMID 1400349.
- Furukawa T, Yoshimura A, Sumizawa T et al. (1992). "Angiogenic factor.". Nature 356 (6371): 668. doi:10.1038/356668a0. PMID 1570012.
- Stenman G, Sahlin P, Dumanski JP et al. (1992). "Regional localization of the human platelet-derived endothelial cell growth factor (ECGF1) gene to chromosome 22q13.". Cytogenet. Cell Genet. 59 (1): 22–3. doi:10.1159/000133191. PMID 1733667.
- Hagiwara K, Stenman G, Honda H et al. (1991). "Organization and chromosomal localization of the human platelet-derived endothelial cell growth factor gene". Mol. Cell. Biol. 11 (4): 2125–32. PMC 359900. PMID 2005900.
- Ishikawa F, Miyazono K, Hellman U et al. (1989). "Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor". Nature 338 (6216): 557–62. doi:10.1038/338557a0. PMID 2467210.
- Bardosi A, Creutzfeldt W, DiMauro S et al. (1987). "Myo-, neuro-, gastrointestinal encephalopathy (MNGIE syndrome) due to partial deficiency of cytochrome-c-oxidase. A new mitochondrial multisystem disorder". Acta Neuropathol. 74 (3): 248–58. doi:10.1007/BF00688189. PMID 2823522.
- Miyazono K, Okabe T, Urabe A et al. (1987). "Purification and properties of an endothelial cell growth factor from human platelets". J. Biol. Chem. 262 (9): 4098–103. PMID 3549724.
- Usuki K, Gonez LJ, Wernstedt C et al. (1994). "Structural properties of 3.0 kb and 3.2 kb transcripts encoding platelet-derived endothelial cell growth factor/thymidine phosphorylase in A431 cells". Biochim. Biophys. Acta 1222 (3): 411–4. doi:10.1016/0167-4889(94)90049-3. PMID 8038210.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Hirano M, Silvestri G, Blake DM et al. (1994). "Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): clinical, biochemical, and genetic features of an autosomal recessive mitochondrial disorder". Neurology 44 (4): 721–7. doi:10.1212/wnl.44.4.721. PMID 8164833.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Stevenson DP, Milligan SR, Collins WP (1998). "Effects of platelet-derived endothelial cell growth factor/thymidine phosphorylase, substrate, and products in a three-dimensional model of angiogenesis". Am. J. Pathol. 152 (6): 1641–6. PMC 1858429. PMID 9626068.
- Nishino I, Spinazzola A, Hirano M (1999). "Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder". Science 283 (5402): 689–92. doi:10.1126/science.283.5402.689. PMID 9924029.
- Asgari MM, Haggerty JG, McNiff JM et al. (1999). "Expression and localization of thymidine phosphorylase/platelet-derived endothelial cell growth factor in skin and cutaneous tumors". J. Cutan. Pathol. 26 (6): 287–94. doi:10.1111/j.1600-0560.1999.tb01846.x. PMID 10472757.
- Loftus BJ, Kim UJ, Sneddon VP et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
- Sivridis E, Giatromanolaki A, Koukourakis MI et al. (2000). "Thymidine phosphorylase expression in normal and hyperplastic endometrium". J. Clin. Pathol. 53 (9): 704–8. doi:10.1136/jcp.53.9.704. PMC 1731246. PMID 11041061.
- Komatsu T, Yamazaki H, Shimada N et al. (2001). "Involvement of microsomal cytochrome P450 and cytosolic thymidine phosphorylase in 5-fluorouracil formation from tegafur in human liver". Clin. Cancer Res. 7 (3): 675–81. PMID 11297264.
- Kojima H, Shijubo N, Abe S (2002). "Thymidine phosphorylase and vascular endothelial growth factor in patients with Stage I lung adenocarcinoma". Cancer 94 (4): 1083–93. doi:10.1002/cncr.10352. PMID 11920479.
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