Dopastin

Dopastin
Names

Systematic IUPAC name (2E)-N-{(2S)-2-[Hydroxy(nitroso)amino]-3-methylbutyl}-2-butenamide
Identifiers
CAS Registry Number	37134-80-8
ChemSpider	4939169
InChI InChI=1S/C9H17N3O3/c1-4-5-9(13)10-6-8(7(2)3)12(15)11-14/h4-5,7-8,15H,6H2,1-3H3,(H,10,13)/b5-4+/t8-/m1/s1 Key: FJUBKTNNXRFHFD-WTSVBCDHSA-N InChI=1/C9H17N3O3/c1-4-5-9(13)10-6-8(7(2)3)12(15)11-14/h4-5,7-8,15H,6H2,1-3H3,(H,10,13)/b5-4+/t8-/m1/s1 Key: FJUBKTNNXRFHFD-WTSVBCDHBR
Jmol-3D images	Image
PubChem	6434226
SMILES O=C(NC[C@@H](N(O)N=O)C(C)C)/C=C/C
Properties
Molecular formula	C₉H₁₇N₃O₃
Molar mass	215.25 g·mol⁻¹
Melting point	116 to 119 °C (241 to 246 °F; 389 to 392 K)^[1]
Acidity (pK_a)	5.1^[1]
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Dopastin is a chemical compound produced by the bacteria Pseudomonas No. BAC-125.^[2] It was first isolated and characterized in 1972. It is an inhibitor of the enzyme dopamine β-hydroxylase.^[3]

Dopastin can be prepared synthetically from L-valinol.^[4]

References

↑ 1.0 1.1 Merck Index, 11th Edition, 3417
↑ Iimura, H; Takeuchi, T; Kondo, S; Matsuzaki, M; Umezawa, H (1972). "Dopastin, an inhibitor of dopamine -hydroxylase". The Journal of antibiotics 25 (8): 497–500. doi:10.7164/antibiotics.25.497. PMID 4648494.
↑ H. Iinuma; M. Matsuzaki; T. Nagatsu; T. Takeuchi; H. Umezawa (1974). "Biochemical and biological studies on dopastin, an inhibitor of dopamine β-hydroxylase". Agric. Biol. Chem. 38 (11): 2107–2111. doi:10.1271/bbb1961.38.2107.
↑ Ohno, M.; Iinuma, H.; Yagisawa, N.; Shibahara, S.; Suhara, Y.; Kondo, S.; Maeda, K.; Umezawa, H. (1973). "Synthesis of dopastin, a dopamine ?-hydroxylase inhibitor of microbial origin". Journal of the Chemical Society, Chemical Communications (4): 147. doi:10.1039/C39730000147.