Dimenoxadol

Dimenoxadol
Systematic (IUPAC) name
2-(dimethylamino)ethyl 2-ethoxy-2,2-diphenylacetate
Clinical data
Identifiers
509-78-4 Yes
None
PubChem CID 17036
DrugBank DB01461 Yes
ChemSpider 16137 Yes
UNII 4D65PBX0VK Yes
ChEMBL CHEMBL2104309
Synonyms Dimenoxadol, Estocin
Chemical data
Formula C20H25NO3
327.42 g/mol
 Yes (what is this?)  (verify)

Dimenoxadol (INN; Estocin), or dimenoxadole (BAN), is an opioid analgesic which is a benzilic acid derivative, closely related to benactyzine (an anticholinergic). Further, the structure is similar to methadone and related compounds like dextropropoxyphene.

It was invented in Germany in the 1950s,[1] and produces similar effects to other opioids, including analgesia, sedation, dizziness and nausea.[2][3][4]

In the United States it is a Schedule I Narcotic controlled substance with an ACSCN of 9617 and a 2013 annual aggregrate manufacturing quota of zero.

References

  1. ↑ GB 716700, Boehringer, A et al., "A new and improved analgesic and process for its production", published 10/13/1954
  2. ↑ Gorbatova, E. N. (1967). "The pharmacology of estocin, an new analgesic". Stomatologiia 46 (2): 22–25. PMID 5232927.
  3. ↑ Kingisepp, G. A.; Kurvits, K.; Nurmand, L. B. (1969). "Pharmacology of dimethylaminoethyl ester of diphenylethoxyacetic acid hydrochloride--estocin". Farmakologiia i toksikologiia 32 (6): 710–712. PMID 5381602.
  4. ↑ Liberman, S. S. (1968). "Analgesic action of estocin (dimethylaminoethyl ester hydrochloride of alpha, alpha-diphenylethoxyacetic acid)". Farmakologiia i toksikologiia 31 (6): 668–671. PMID 5729519.