Dietmar Vestweber

Dietmar Vestweber (born 1956) is a biochemist and cell biologist. He is the founding director of the Max-Planck-Institute for Molecular Biomedicine in Münster, Germany.

Biography

Dietmar Vestweber studied biochemistry at the Universities of Tübingen and Munich and at the Max-Planck-Institute of Biochemistry in Martinsried. He received his PhD from the University of Tübingen in 1985 for his research conducted at the Max-Planck-Institute for Developmental Biology.

For his post-doctoral studies he went to the Biocenter of the University of Basel where he received his habilitation in 1990. In the same year he started as head of a research group at the Max-Planck Institute of Immunobiology in Freiburg and assumed in 1994 a professorship for Cell Biology at the medical school of the University of Münster.

In 1999 he assumed the position of a director at the Max-Planck-Institute of physiological and clinical research, which he held until 2001 when he became the director of the newly founded Max-Planck-Institute for Molecular Biomedicine in Münster.

Research

Vestweber has worked in three different areas of molecular biology. During his studies for his PhD in the laboratory of Rolf Kemler he investigated the molecular mechanisms of cell recognition and cell adhesion between epithelial cells and during the development of the mouse preimplantation embryo, working on the adhesion molecule E-cadherin (uvomorulin).[1]

In the course of his postdoctoral work in the group of Gottfried Schatz at the Biocenter in Basel, Vestweber studied the biogenesis of mitochondria and found the first membrane component (today known as TOM 40) of the mitochondrial import machinery for the transport of proteins into this organelle.[2]

Since 1990 he investigates molecular mechanisms that control inflammation. Inflammation relies on the entry of leukocytes from the blood into infected or otherwise damaged tissues. Vestweber studies with his group the molecular basis for cell recognition, cell adhesion and cell migration, which mediate and control this process.[3][4] At present the group focuses in this context on mechanisms that control the barrier function of the vascular endothelium and the blood vessel wall.

The nearly 200 of Vestweber's publications were cited over 14,000 times. His Hirsch-Index is 73 (status December 2011).

Awards

References

  1. ↑ Vestweber, D; Kemler, R (1984). "Rabbit antiserum against a purified surface glycoprotein decompacts mouse preimplantation embryos and reacts with specific adult tissues". Experimental cell research 152 (1): 169–78. doi:10.1016/0014-4827(84)90241-6. PMID 6370707.
  2. ↑ Vestweber, D; Brunner, J; Baker, A; Schatz, G (1989). "A 42K outer-membrane protein is a component of the yeast mitochondrial protein import site". Nature 341 (6239): 205–9. doi:10.1038/341205a0. PMID 2674724.
  3. ↑ Schulte, D; Küppers, V; Dartsch, N; Broermann, A; Li, H; Zarbock, A; Kamenyeva, O; Kiefer, F; Khandoga, A (2011). "Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability". The EMBO Journal 30 (20): 4157–70. doi:10.1038/emboj.2011.304. PMC 3199392. PMID 21857650.
  4. ↑ Lühn, K; Wild, MK; Eckhardt, M; Gerardy-Schahn, R; Vestweber, D (2001). "The gene defective in leukocyte adhesion deficiency II encodes a putative GDP-fucose transporter". Nature Genetics 28 (1): 69–72. doi:10.1038/88289. PMID 11326279.

External links