Death-inducing signaling complex

Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps

The death-inducing signaling complex or DISC is a multi-protein complex formed by members of the "death receptor" family of apoptosis-inducing cellular receptors.^[1] A typical example is FasR, which forms the DISC upon trimerization as a result of its ligand (FasL) binding. Dogma states that the DISC is composed of the death receptor, FADD, and caspase 8. It transduces a downstream signal cascade resulting in apoptosis.

References

↑ Kischkel, FC; Hellbardt, S; Behrmann, I; Germer, M; Pawlita, M; Krammer, PH; Peter, ME (Nov 15, 1995). "Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.". The EMBO Journal 14 (22): 5579–88. PMC 394672. PMID 8521815. Retrieved 8 May 2011.

External links

DISC (Death Inducing Signaling Complex) at the US National Library of Medicine Medical Subject Headings (MeSH)

Cell signaling: carrier proteins: signal transducing adaptor proteins

JAK-STAT

see JAK-STAT signaling pathway

Growth factor receptor-bound protein

Other

14-3-3 YWHAE YWHAZ Caveolin Cortactin Death-inducing signaling complex Paxillin MYD88 SMAD TRAF TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6) BIN1 SH3BP2 LDB3

CHM CHML

Index of signal transduction

Description	Intercellular neuropeptides growth factors cytokines hormones Cell surface receptors ligand-gated enzyme-linked G protein-coupled immunoglobulin superfamily integrins neuropeptide growth factor cytokine Intracellular adaptor proteins GTP-binding MAP kinase Calcium signaling Lipid signaling Pathways hedgehog Wnt TGF beta MAPK ERK notch JAK-STAT apoptosis hippo TLR

Apoptosis signaling pathway

Fas path

Ligand	Fas ligand

Receptor	Fas receptor

Intracellular	Death-inducing signaling complex DAXX ASK1 FADD Caspase 8 BID Cytochrome c Caspase 9 Caspase 3 Pro-apoptotic: BAX BAK1/Bcl-2 homologous antagonist killer Bcl-2-associated death promoter Anti-apoptotic: Bcl-2 Bcl-xL

TNF path

Ligand	Tumor necrosis factor alpha

Receptor	Tumor necrosis factor receptor 1 Tumor necrosis factor receptor 2

Intracellular	TRADD FADD Caspase 8 Caspase 3 BID TRAF2 ASK-1 MEKK1 IKK IκBα MKK7 JNK NF-κB

Other

Intracellular	IAPs XIAP NAIP Survivin c-IAP-1 c-IAP-2 Apoptosis-inducing factor

Index of signal transduction

Description	Intercellular neuropeptides growth factors cytokines hormones Cell surface receptors ligand-gated enzyme-linked G protein-coupled immunoglobulin superfamily integrins neuropeptide growth factor cytokine Intracellular adaptor proteins GTP-binding MAP kinase Calcium signaling Lipid signaling Pathways hedgehog Wnt TGF beta MAPK ERK notch JAK-STAT apoptosis hippo TLR