DYNLL2

Dynein, light chain, LC8-type 2

PDB rendering based on 1cmi.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2XQQ, 3P8M

Identifiers

Symbols

DYNLL2 ; DNCL1B; Dlc2; RSPH22

External IDs

OMIM: 608942 MGI: 1915347 HomoloGene: 115597 GeneCards: DYNLL2 Gene

Gene ontology
Molecular function	• motor activity • cytoskeletal protein binding
Cellular component	• nucleus • centrosome • cytosol • microtubule • plasma membrane • membrane • myosin complex • dynein complex
Biological process	• transport • apoptotic process • microtubule-based process • synaptic target recognition • metabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class II • intrinsic apoptotic signaling pathway • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
56.16 – 56.17 Mb

Chr 11:
87.98 – 87.99 Mb

PubMed search

Dynein light chain 2, cytoplasmic is a protein that in humans is encoded by the DYNLL2 gene.^[1]^[2]

Interactions

DYNLL2 has been shown to interact with DLG4,^[3] DLGAP1,^[3] MYO5A^[3]^[4] and BMF.^[4]^[5]

References

↑ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (November 2005). "Cytoplasmic dynein nomenclature". J Cell Biol 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
↑ "Entrez Gene: DYNLL2 dynein, light chain, LC8-type 2".
↑ 3.0 3.1 3.2 Naisbitt, S; Valtschanoff J; Allison D W; Sala C; Kim E; Craig A M; Weinberg R J; Sheng M (June 2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein". J. Neurosci. (UNITED STATES) 20 (12): 4524–34. ISSN 0270-6474. PMID 10844022.
↑ 4.0 4.1 Puthalakath, H; Villunger A; O'Reilly L A; Beaumont J G; Coultas L; Cheney R E; Huang D C; Strasser A (September 2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis". Science (United States) 293 (5536): 1829–32. doi:10.1126/science.1062257. ISSN 0036-8075. PMID 11546872.
↑ Day, Catherine L; Puthalakath Hamsa; Skea Gretchen; Strasser Andreas; Barsukov Igor; Lian Lu-Yun; Huang David C S; Hinds Mark G (February 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". Biochem. J. (England) 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMC 1223895. PMID 14561217.

Naisbitt S, Valtschanoff J, Allison DW et al. (2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein.". J. Neurosci. 20 (12): 4524–34. PMID 10844022.
Haraguchi K, Satoh K, Yanai H et al. (2001). "The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthase.". Genes Cells 5 (11): 905–911. doi:10.1046/j.1365-2443.2000.00374.x. PMID 11122378.
Puthalakath H, Villunger A, O'Reilly LA et al. (2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis.". Science 293 (5536): 1829–32. doi:10.1126/science.1062257. PMID 11546872.
Fuhrmann JC, Kins S, Rostaing P et al. (2002). "Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes.". J. Neurosci. 22 (13): 5393–402. PMID 12097491.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Day CL, Puthalakath H, Skea G et al. (2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands.". Biochem. J. 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMC 1223895. PMID 14561217.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

PDB gallery

1cmi: STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE

1f3c: REFINED SOLUTION STRUCTURE OF 8KDA DYNEIN LIGHT CHAIN (DLC8)

1f95: SOLUTION STRUCTURE OF DYNEIN LIGHT CHAIN 8 (DLC8) AND BIM PEPTIDE COMPLEX

1f96: SOLUTION STRUCTURE OF DYNEIN LIGHT CHAIN 8 (DLC8) AND NNOS PEPTIDE COMPLEX

1pwj: Structure of the Monomeric 8-kDa Dynein Light Chain and Mechanism of Domain Swapped Dimer Assembly

1pwk: Structure of the Monomeric 8-kDa Dynein Light Chain and Mechanism of Domain Swapped Dimer Assembly

1re6: Localisation of Dynein Light Chains 1 and 2 and their Pro-apoptotic Ligands

1rhw: The solution structure of the pH-induced monomer of dynein light chain LC8 from Drosophila

2pg1: Structural analysis of a cytoplasmic dynein Light Chain-Intermediate Chain complex

DYNLL2 associations with risk for generalized anxiety disorder: Donner et al. An Association Analysis of Murine Anxiety Genes in Humans Implicates Novel Candidate Genes for Anxiety Disorders. Biological Psychiatry, 2008; 64 (8): 672 doi:10.1016/j.biopsych.2008.06.002

DYNLL2

Interactions

References

Further reading