DYNC1LI2

Dynein, cytoplasmic 1, light intermediate chain 2

Identifiers

DYNC1LI2 ; DNCLI2; LIC2

External IDs

OMIM: 611406 MGI: 107738 HomoloGene: 4474 GeneCards: DYNC1LI2 Gene

Gene ontology
Molecular function	• microtubule motor activity • ATP binding
Cellular component	• centrosome • cytosol • cytoplasmic dynein complex • microtubule • membrane
Biological process	• microtubule cytoskeleton organization • transport • microtubule-based movement • metabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class II • centrosome localization
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000135720

ENSMUSG00000035770

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 16:
66.75 – 66.79 Mb

Chr 8:
104.42 – 104.44 Mb

PubMed search

Cytoplasmic dynein 1 light intermediate chain 2 is a protein that in humans is encoded by the DYNC1LI2 gene.^[1]^[2]

References

↑ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
↑ "Entrez Gene: DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2".

Further reading

Hughes SM, Vaughan KT, Herskovits JS, Vallee RB (1995). "Molecular analysis of a cytoplasmic dynein light intermediate chain reveals homology to a family of ATPases.". J. Cell. Sci. 108 (1): 17–24. PMID 7738094.
Chagnon P, Michaud J, Mitchell G et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis.". Am. J. Hum. Genet. 71 (6): 1443–9. doi:10.1086/344580. PMC 378590. PMID 12417987.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Villén J, Gerber SA et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.