DTL (gene)

Denticleless E3 ubiquitin protein ligase homolog (Drosophila)

Identifiers

DTL ; CDT2; DCAF2; L2DTL; RAMP

External IDs

OMIM: 610617 MGI: 1924093 HomoloGene: 32313 GeneCards: DTL Gene

Gene ontology
Molecular function	• ubiquitin-protein transferase activity • protein binding
Cellular component	• nucleus • chromosome • nucleolus • cytoplasm • centrosome • Cul4A-RING E3 ubiquitin ligase complex • Cul4B-RING E3 ubiquitin ligase complex • nuclear membrane • intracellular membrane-bounded organelle
Biological process	• protein polyubiquitination • DNA replication • ubiquitin-dependent protein catabolic process • protein monoubiquitination • cellular response to DNA damage stimulus • response to UV • translesion synthesis • G2 DNA damage checkpoint • regulation of cell cycle
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000143476

ENSMUSG00000037474

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
212.21 – 212.28 Mb

Chr 1:
191.54 – 191.58 Mb

PubMed search

Denticleless protein homolog is a protein that in humans is encoded by the DTL gene.^[1]^[2]

Interactions

DTL (gene) has been shown to interact with P21.^[3]

References

↑ Cheung WM, Chu AH, Chu PW, Ip NY (May 2001). "Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation". J Biol Chem 276 (20): 17083–91. doi:10.1074/jbc.M010802200. PMID 11278750.
↑ "Entrez Gene: DTL denticleless homolog (Drosophila)".
↑ Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A (Sep 2008). "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex". Genes Dev. 22 (18): 2496–506. doi:10.1101/gad.1676108. PMC 2546691. PMID 18794347.

Further reading

Banks D, Wu M, Higa LA, Gavrilova N, Quan J, Ye T et al. (2007). "L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes.". Cell Cycle 5 (15): 1719–29. doi:10.4161/cc.5.15.3150. PMID 16861890.
Higa LA, Banks D, Wu M, Kobayashi R, Sun H, Zhang H (2007). "L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage.". Cell Cycle 5 (15): 1675–80. doi:10.4161/cc.5.15.3149. PMID 16861906.
Jin J, Arias EE, Chen J, Harper JW, Walter JC (2006). "A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.". Mol. Cell 23 (5): 709–21. doi:10.1016/j.molcel.2006.08.010. PMID 16949367.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. Vancouver style error (help)
Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H (2006). "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.". Nat. Cell Biol. 8 (11): 1277–83. doi:10.1038/ncb1490. PMID 17041588.
Sansam CL, Shepard JL, Lai K, Ianari A, Danielian PS, Amsterdam A et al. (2006). "DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint.". Genes Dev. 20 (22): 3117–29. doi:10.1101/gad.1482106. PMC 1635147. PMID 17085480.
Pan HW, Chou HY, Liu SH, Peng SY, Liu CL, Hsu HC (2007). "Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma.". Cell Cycle 5 (22): 2676–87. doi:10.4161/cc.5.22.3500. PMID 17106265.