DNPEP
Aspartyl aminopeptidase is an enzyme that in humans is encoded by the DNPEP gene.[1][2]
The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins.[2]
References
Further reading
- Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Prieto I, Hermoso F, Gasparo M et al. (2004). "Angiotensinase activities in the kidney of renovascular hypertensive rats.". Peptides 24 (5): 755–60. doi:10.1016/S0196-9781(03)00121-9. PMID 12895663.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wilk S, Wilk E, Magnusson RP (2002). "Identification of histidine residues important in the catalysis and structure of aspartyl aminopeptidase.". Arch. Biochem. Biophys. 407 (2): 176–83. doi:10.1016/S0003-9861(02)00494-0. PMID 12413488.
External links
- The MEROPS online database for peptidases and their inhibitors: M18.002
