DLL3
| Delta-like 3 (Drosophila) | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | DLL3 ; SCDO1 | ||||||||||||
| External IDs | OMIM: 602768 MGI: 1096877 HomoloGene: 7291 GeneCards: DLL3 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10683 | 13389 | |||||||||||
| Ensembl | ENSG00000090932 | ENSMUSG00000003436 | |||||||||||
| UniProt | Q9NYJ7 | O88516 | |||||||||||
| RefSeq (mRNA) | NM_016941 | NM_007866 | |||||||||||
| RefSeq (protein) | NP_058637 | NP_031892 | |||||||||||
| Location (UCSC) | Chr 19: 39.99 – 40 Mb | Chr 7: 28.29 – 28.3 Mb | |||||||||||
| PubMed search | |||||||||||||
Delta-like 3 (Drosophila), also known as DLL3, is a protein which in humans is encoded by the DLL3 gene.[1] Two transcript variants encoding distinct isoforms have been identified for this gene.
Function
This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.[2]
Clinical significance
Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1.[3]
External links
References
- ↑ Turnpenny PD, Bulman MP, Frayling TM, Abu-Nasra TK, Garrett C, Hattersley AT, Ellard S (July 1999). "A gene for autosomal recessive spondylocostal dysostosis maps to 19q13.1-q13.3". Am. J. Hum. Genet. 65 (1): 175–82. doi:10.1086/302464. PMC 1378088. PMID 10364530.
- ↑ "Entrez Gene: DLL3 delta-like 3 (Drosophila)".
- ↑ Bulman MP, Kusumi K, Frayling TM, McKeown C, Garrett C, Lander ES, Krumlauf R, Hattersley AT, Ellard S, Turnpenny PD (April 2000). "Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis". Nat. Genet. 24 (4): 438–41. doi:10.1038/74307. PMID 10742114.
Further reading
- Turnpenny PD, Bulman MP, Frayling TM et al. (1999). "A gene for autosomal recessive spondylocostal dysostosis maps to 19q13.1-q13.3.". Am. J. Hum. Genet. 65 (1): 175–82. doi:10.1086/302464. PMC 1378088. PMID 10364530.
- Bulman MP, Kusumi K, Frayling TM et al. (2000). "Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis.". Nat. Genet. 24 (4): 438–41. doi:10.1038/74307. PMID 10742114.
- Dunwoodie SL, Clements M, Sparrow DB et al. (2002). "Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm.". Development 129 (7): 1795–806. PMID 11923214.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Turnpenny PD, Whittock N, Duncan J et al. (2003). "Novel mutations in DLL3, a somitogenesis gene encoding a ligand for the Notch signalling pathway, cause a consistent pattern of abnormal vertebral segmentation in spondylocostal dysostosis.". J. Med. Genet. 40 (5): 333–9. doi:10.1136/jmg.40.5.333. PMC 1735475. PMID 12746394.
- Bonafé L, Giunta C, Gassner M et al. (2004). "A cluster of autosomal recessive spondylocostal dysostosis caused by three newly identified DLL3 mutations segregating in a small village.". Clin. Genet. 64 (1): 28–35. doi:10.1034/j.1399-0004.2003.00085.x. PMID 12791036.
- Whittock NV, Ellard S, Duncan J et al. (2005). "Pseudodominant inheritance of spondylocostal dysostosis type 1 caused by two familial delta-like 3 mutations.". Clin. Genet. 66 (1): 67–72. doi:10.1111/j.0009-9163.2004.00272.x. PMID 15200511.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Maisenbacher MK, Han JS, O'brien ML et al. (2005). "Molecular analysis of congenital scoliosis: a candidate gene approach.". Hum. Genet. 116 (5): 416–9. doi:10.1007/s00439-005-1253-8. PMID 15717203.
- Otsuki T, Ota T, Nishikawa T et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
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